Angiotensin Blockade and Progressive Loss of Kidney Function in Hemodialysis Patients: A Randomized Controlled Trial

Background Glomerular filtration rate (GFR) declines during long-term dialysis treatment. In peritoneal dialysis, blockade of the renin-angiotensin-aldosterone system reduces GFR decline. Observational studies suggest that similar treatment may preserve kidney function in hemodialysis (HD). Study De...

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Veröffentlicht in:	American journal of kidney diseases 2014-12, Vol.64 (6), p.892-901
Hauptverfasser:	Kjaergaard, Krista Dybtved, MD, PhD, Peters, Christian Daugaard, MD, PhD, Jespersen, Bente, MD, DrMedSc, Tietze, Ida Nørager, MD, PhD, Madsen, Jens Kristian, MD, PhD, Pedersen, Birgitte Bang, MD, PhD, Novosel, Marija Kristina, MD, Laursen, Kathrine Skaaning, MD, Bibby, Bo Martin, PhD, Strandhave, Charlotte, MD, Jensen, Jens Dam, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged albuminuria aldosterone Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy angiotensin II angiotensin II receptor blocker Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensins - antagonists & inhibitors Angiotensins - physiology anuria Biological and medical sciences Biphenyl Compounds - therapeutic use Disease Progression Double-Blind Method double-blinded Emergency and intensive care: renal failure. Dialysis management Female Follow-Up Studies GFR decline glomerular filtration rate (GFR) hemodialysis (HD) Humans Intensive care medicine investigator-initiated irbesartan Kidney - drug effects Kidney - physiology Male Medical sciences Middle Aged multicenter study Nephrology Nephrology. Urinary tract diseases placebo preservation of residual renal function randomized controlled trial Renal Dialysis - adverse effects Renal Dialysis - trends Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - therapy renin residual renal function SAFIR (Saving Residual Renal Function in Hemodialysis Patients Receiving Irbesartan) trial Tetrazoles - therapeutic use Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland urine volume
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