Impaired responses to gliadin and gut microbes of immune cells from mice with altered stress-related behavior and premature immune senescence
Abstract Stress is associated with impaired communication between the nervous and immune systems leading to immunosenescence and increased disease risk. We investigated whether leukocytes from mice with altered stress-related behavior and premature immunosenescence, as well as from chronologically a...
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| Veröffentlicht in: | Journal of neuroimmunology 2014-11, Vol.276 (1), p.47-57 |
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| container_title | Journal of neuroimmunology |
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| creator | De Palma, G Vida, C Santacruz, A De Castro, N.M De la Fuente, M Sanz, Y |
| description | Abstract Stress is associated with impaired communication between the nervous and immune systems leading to immunosenescence and increased disease risk. We investigated whether leukocytes from mice with altered stress-related behavior and premature immunosenescence, as well as from chronologically aged mice differently responded ex vivo to celiac disease (CD) triggers (gliadin) and intestinal bacteria by ELISA and flow cytometry and differed in microbiota composition. We found that altered stress-related behavior and premature immunosenescence led to alterations in T lymphocytes and cytokine release of immune cells basally and in response to peptic fragments of gliadin and commensal and pathogenic bacteria, possibly increasing susceptibility to CD in adulthood. |
| doi_str_mv | 10.1016/j.jneuroim.2014.08.007 |
| format | Article |
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We investigated whether leukocytes from mice with altered stress-related behavior and premature immunosenescence, as well as from chronologically aged mice differently responded ex vivo to celiac disease (CD) triggers (gliadin) and intestinal bacteria by ELISA and flow cytometry and differed in microbiota composition. We found that altered stress-related behavior and premature immunosenescence led to alterations in T lymphocytes and cytokine release of immune cells basally and in response to peptic fragments of gliadin and commensal and pathogenic bacteria, possibly increasing susceptibility to CD in adulthood.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2014.08.007</identifier><identifier>PMID: 25176132</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aging ; Aging - immunology ; Allergy and Immunology ; Analysis of Variance ; Animals ; Bifidobacteriales Infections - immunology ; Bifidobacteriales Infections - pathology ; Celiac disease ; Celiac Disease - chemically induced ; Celiac Disease - immunology ; Cytokines - metabolism ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Gliadin - adverse effects ; Intestinal bacteria ; Leukocytes ; Mice ; Mice, Inbred ICR ; Neurology ; Stress, Psychological - pathology ; Stress-related behavior ; T-Lymphocytes - immunology</subject><ispartof>Journal of neuroimmunology, 2014-11, Vol.276 (1), p.47-57</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-29e2db03acd39303c946f7d0f669ad984efa9ac251a6383fc6f8f344abce06fe3</citedby><cites>FETCH-LOGICAL-c493t-29e2db03acd39303c946f7d0f669ad984efa9ac251a6383fc6f8f344abce06fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2014.08.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25176132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Palma, G</creatorcontrib><creatorcontrib>Vida, C</creatorcontrib><creatorcontrib>Santacruz, A</creatorcontrib><creatorcontrib>De Castro, N.M</creatorcontrib><creatorcontrib>De la Fuente, M</creatorcontrib><creatorcontrib>Sanz, Y</creatorcontrib><title>Impaired responses to gliadin and gut microbes of immune cells from mice with altered stress-related behavior and premature immune senescence</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Stress is associated with impaired communication between the nervous and immune systems leading to immunosenescence and increased disease risk. We investigated whether leukocytes from mice with altered stress-related behavior and premature immunosenescence, as well as from chronologically aged mice differently responded ex vivo to celiac disease (CD) triggers (gliadin) and intestinal bacteria by ELISA and flow cytometry and differed in microbiota composition. We found that altered stress-related behavior and premature immunosenescence led to alterations in T lymphocytes and cytokine release of immune cells basally and in response to peptic fragments of gliadin and commensal and pathogenic bacteria, possibly increasing susceptibility to CD in adulthood.</description><subject>Aging</subject><subject>Aging - immunology</subject><subject>Allergy and Immunology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Bifidobacteriales Infections - immunology</subject><subject>Bifidobacteriales Infections - pathology</subject><subject>Celiac disease</subject><subject>Celiac Disease - chemically induced</subject><subject>Celiac Disease - immunology</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Gliadin - adverse effects</subject><subject>Intestinal bacteria</subject><subject>Leukocytes</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Neurology</subject><subject>Stress, Psychological - pathology</subject><subject>Stress-related behavior</subject><subject>T-Lymphocytes - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1TAQhS0EopfCK1ReskkY27lOvEGgip9KlVgAa8txxq0vcRzspKgPwTvj9PayYMPKsubMN5pzhpALBjUDJt8c6sOEa4o-1BxYU0NXA7RPyI51La-6hrOnZFeE-2rf8u6MvMj5AMD2olHPyRnfs1YywXfk91WYjU840IR5jlPGTJdIb0ZvBj9RMw30Zl1o8DbFvtSioz6EdUJqcRwzdSmGrYr0l19uqRkX3GB5KbhcJRzNUr493po7H9MDb04YzLImPJEyTpgtThZfkmfOjBlfPb7n5PvHD98uP1fXXz5dXb6_rmyjxFJxhXzoQRg7CCVAWNVI1w7gpFRmUF2Dzihjy5ZGik44K13nRNOY3iJIh-KcvD5y5xR_rpgXHXzeFjITxjVrJrlSrVTQFqk8SosBOSd0ek4-mHSvGegtCn3Qpyj0FoWGTsND48XjjLUPOPxtO3lfBO-OAiyb3nlMOlu_uTCUPOyih-j_P-PtPwg7-slbM_7Ae8yHuKap-KiZzlyD_rodxHYPrAHgDSjxB5PtttQ</recordid><startdate>20141115</startdate><enddate>20141115</enddate><creator>De Palma, G</creator><creator>Vida, C</creator><creator>Santacruz, A</creator><creator>De Castro, N.M</creator><creator>De la Fuente, M</creator><creator>Sanz, Y</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141115</creationdate><title>Impaired responses to gliadin and gut microbes of immune cells from mice with altered stress-related behavior and premature immune senescence</title><author>De Palma, G ; Vida, C ; Santacruz, A ; De Castro, N.M ; De la Fuente, M ; Sanz, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-29e2db03acd39303c946f7d0f669ad984efa9ac251a6383fc6f8f344abce06fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aging</topic><topic>Aging - immunology</topic><topic>Allergy and Immunology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Bifidobacteriales Infections - immunology</topic><topic>Bifidobacteriales Infections - pathology</topic><topic>Celiac disease</topic><topic>Celiac Disease - chemically induced</topic><topic>Celiac Disease - immunology</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Gliadin - adverse effects</topic><topic>Intestinal bacteria</topic><topic>Leukocytes</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Neurology</topic><topic>Stress, Psychological - pathology</topic><topic>Stress-related behavior</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Palma, G</creatorcontrib><creatorcontrib>Vida, C</creatorcontrib><creatorcontrib>Santacruz, A</creatorcontrib><creatorcontrib>De Castro, N.M</creatorcontrib><creatorcontrib>De la Fuente, M</creatorcontrib><creatorcontrib>Sanz, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Palma, G</au><au>Vida, C</au><au>Santacruz, A</au><au>De Castro, N.M</au><au>De la Fuente, M</au><au>Sanz, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired responses to gliadin and gut microbes of immune cells from mice with altered stress-related behavior and premature immune senescence</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2014-11-15</date><risdate>2014</risdate><volume>276</volume><issue>1</issue><spage>47</spage><epage>57</epage><pages>47-57</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Stress is associated with impaired communication between the nervous and immune systems leading to immunosenescence and increased disease risk. 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| ispartof | Journal of neuroimmunology, 2014-11, Vol.276 (1), p.47-57 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging Aging - immunology Allergy and Immunology Analysis of Variance Animals Bifidobacteriales Infections - immunology Bifidobacteriales Infections - pathology Celiac disease Celiac Disease - chemically induced Celiac Disease - immunology Cytokines - metabolism Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Gliadin - adverse effects Intestinal bacteria Leukocytes Mice Mice, Inbred ICR Neurology Stress, Psychological - pathology Stress-related behavior T-Lymphocytes - immunology |
| title | Impaired responses to gliadin and gut microbes of immune cells from mice with altered stress-related behavior and premature immune senescence |
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