Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells

•Determined the apigenin moiety responsible for K562 erythroid differentiation.•Structure–activity of apigenin compared with apigetrin and five flavonoids.•The sugar moiety in apigenin is not necessary for cell differentiation induction.•Erythroid differentiation possibly due to hydroxyl group and C...

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Veröffentlicht in:	Chemico-biological interactions 2014-09, Vol.220, p.269-277
Hauptverfasser:	Isoda, Hiroko, Motojima, Hideko, Onaga, Shoko, Samet, Imen, Villareal, Myra O., Han, Junkyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apigenin Apigenin - chemistry Apigenin - pharmacology Cell Differentiation - drug effects Erythroid Cells - cytology Erythroid Cells - drug effects Erythroid differentiation Flavonoid Humans K562 Cells Molecular Structure Polymerase Chain Reaction Structure–activity relationship
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