Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients

Abstract We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G...

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Veröffentlicht in:	Human immunology 2014-11, Vol.75 (11), p.1075-1083
Hauptverfasser:	Tarragô, Andréa Monteiro, da Costa, Allyson Guimarães, Pimentel, João Paulo Diniz, Gomes, Samara Tatielle Monteiro, Freitas, Felipe Bonfim, Lalwani, Pritesh, de Araújo, Ana Ruth S, da Silva Victória, Flamir, Victória, Marilú Barbieri, Vallinoto, Antônio Carlos Rosário, Sadahiro, Aya, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Malheiro, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Case-Control Studies Female Genotype HCV genotype Hepacivirus - genetics Hepacivirus - growth & development Hepatitis C, Chronic - blood Hepatitis C, Chronic - genetics Hepatitis C, Chronic - virology Host-Pathogen Interactions Humans Interferon-gamma - blood Interleukin-10 Interleukin-10 - blood Interleukin-10 - genetics Interleukin-17 - blood Interleukin-2 - blood Interleukin-4 - blood Interleukin-6 Interleukin-6 - blood Interleukin-6 - genetics Male Polymorphism Polymorphism, Genetic Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α
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