Synergism of arsenic trioxide and MG132 in Raji cells attained by targeting BNIP3, autophagy, and mitochondria with low doses of valproic acid and vincristine

Abstract We previously demonstrated that arsenic trioxide (ATO) and proteasome inhibitor MG132 synergistically induced cell death in promonocytic leukaemia cell line U937 but were antagonistic in Burkitt’s lymphoma cell line Raji. Here we explore the role of autophagy, expression of BNIP3, and mitoc...

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Veröffentlicht in:	European journal of cancer (1990) 2014-12, Vol.50 (18), p.3243-3261
Hauptverfasser:	Cavaliere, Victoria, Lombardo, Tomás, Costantino, Susana N, Kornblihtt, Laura, Alvarez, Elida M, Blanco, Guillermo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Arsenic trioxide Arsenicals - pharmacology Autophagy Autophagy - drug effects Biological and medical sciences BNIP3 Burkitt’s lymphoma Cell Line, Tumor Cell Survival - drug effects Drug Synergism Enzyme Inhibitors - pharmacology Hematology, Oncology and Palliative Medicine Humans Leupeptins - pharmacology Medical sciences Membrane Potential, Mitochondrial - drug effects Membrane Potentials - drug effects Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism MG132 Mitochondria Mitochondria - drug effects Mitophagy Oxides - pharmacology Pharmacology. Drug treatments Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Synergism Targeted combined therapies Tumors U937 Cells Up-Regulation Valproic acid Valproic Acid - administration & dosage Valproic Acid - pharmacology Vincristine - administration & dosage Vincristine - pharmacology
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