Deuterohemin-AlaHisLys mitigates the symptoms of rats with non-insulin dependent diabetes mellitus by scavenging reactive oxygen species and activating the PI3-K/AKT signal transduction pathway

[Display omitted] •Deuterohemin-AlaHisLys (DhHP-3), a peroxidase mimetic, mitigates the symptoms of rats with non-insulin dependent diabetes mellitus.•DhHP-3 protects pancreatic β-cells and promotes cell proliferation.•DhHP-3 scavenges reactive oxygen species induced by hyperglycemia.•PI3-K/AKT sign...

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Veröffentlicht in:	Chemico-biological interactions 2014-09, Vol.220, p.64-74
Hauptverfasser:	Lei, Liyan, Zhang, Guangji, Li, Pengfei, Zhang, Yuan, Guo, Youming, Zhang, Wenqi, Zhang, Wenbo, Hu, Bing, Wang, Liping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line Cell Proliferation - drug effects Deuterohemin-AlaHisLys Diabetes Mellitus, Experimental - drug therapy Male Metalloporphyrins - chemistry Metalloporphyrins - pharmacology Metalloporphyrins - therapeutic use Molecular Structure Non-insulin dependent diabetes mellitus Oligopeptides - chemistry Oligopeptides - pharmacology Oligopeptides - therapeutic use Oncogene Protein v-akt - metabolism Pancreas - cytology Pancreas - metabolism Phosphatidylinositol 3-Kinases - metabolism PI3-K/AKT pathway Rats Reactive Oxygen Species - metabolism ROS Signal Transduction - drug effects Up-Regulation
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