Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus

Immunity against viruses and plasmids provided by CRISPR-Cas systems relies on a ribonucleoprotein effector complex that triggers the degradation of invasive nucleic acids (NA). Effector complexes of type I (Cascade) and II (Cas9-dual RNA) target foreign DNA. Intriguingly, the genetic evidence sugge...

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Veröffentlicht in:	Molecular cell 2014-11, Vol.56 (4), p.506-517
Hauptverfasser:	Tamulaitis, Gintautas, Kazlauskiene, Migle, Manakova, Elena, Venclovas, Česlovas, Nwokeoji, Alison O., Dickman, Mark J., Horvath, Philippe, Siksnys, Virginijus
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Associated Proteins - chemistry CRISPR-Associated Proteins - genetics CRISPR-Associated Proteins - metabolism Endoribonucleases - genetics Endoribonucleases - metabolism Molecular Sequence Data Protein Binding Protein Structure, Quaternary RNA Cleavage Scattering, Small Angle Streptococcus thermophilus - enzymology Streptococcus thermophilus - genetics X-Ray Diffraction
Online-Zugang:	Volltext
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