Vitamin K1 monitoring in pregnancies after bariatric surgery: a prospective cohort study
Abstract Background Neonatal intracranial bleedings and birth defects have been reported, possibly related to maternal vitamin K1 deficiency during pregnancy after bariatric surgery. The objective of this study was to investigate the effects of screening and supplementation on K1 serum levels in pre...
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| Veröffentlicht in: | Surgery for obesity and related diseases 2014-09, Vol.10 (5), p.885-890 |
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| creator | Jans, Goele, M.S Guelinckx, Isabelle, Ph.D Voets, Willy, M.D., Ph.D Galjaard, Sander, M.D Van Haard, Paul M.M., Ph.D Vansant, Greet M., Ph.D Devlieger, Roland, M.D., Ph.D |
| description | Abstract Background Neonatal intracranial bleedings and birth defects have been reported, possibly related to maternal vitamin K1 deficiency during pregnancy after bariatric surgery. The objective of this study was to investigate the effects of screening and supplementation on K1 serum levels in pregnant women with bariatric surgery, and to compare K1 levels and prothrombin time (PT %) in the first trimester with pregnant women without bariatric surgery. Methods A prospective cohort study including 49 pregnant women with bariatric surgery. Nutritional deficiencies were prospectively screened. In case of observed low K1 serum levels, supplementation was provided. K1 serum levels and PT (%) during the first trimester were compared with a nonsurgical control group of 27 women. Results During the first trimester, most women had low K1 serum levels ( |
| doi_str_mv | 10.1016/j.soard.2014.04.032 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1629969719</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1550728914002147</els_id><sourcerecordid>1629969719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-fa6fb90a56e179f3ab9b2b1449a549fe4361f437f095d741bc2717a84b6f64163</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7of-AkH66KXHVJJOJoKCLLsqLuzBD7yFdLoyZuxOj0l6Yf79ZpzVg5eFggrF-6aqniLkBdAVUJCvt6s82zSsGAWxojU4e0ROYa3Wreo4f1zfXUdbxdb6hJzlvKWUy06xp-SEdUwKzukp-fE9FDuF2HyGZppjKHMKcdPUwi7hJtroAubG-oKp6W0KtqTgmrykDab9m8ZW2Zx36Eq4xcbNP-dUmlyWYf-MPPF2zPj8Pp-Tb1eXXy8-ttc3Hz5dvL9unQBRWm-l7zW1nURQ2nPb6571IIS2ndAeBZfgBVee6m5QAnrHFCi7Fr30UoDk5-TV8d86yO8FczFTyA7H0Uacl2xAMq2lVqCrlB-lrs6cE3qzS2GyaW-AmgNSszV_kJoDUkNrcFZdL-8bLP2Ewz_PX4ZV8PYowLrmbcBkcoUWHQ4hVTBmmMMDDd7953djiMHZ8RfuMW_nJcVK0IDJzFDz5XDVw1FBUMpAKH4HP1-dtg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1629969719</pqid></control><display><type>article</type><title>Vitamin K1 monitoring in pregnancies after bariatric surgery: a prospective cohort study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Jans, Goele, M.S ; Guelinckx, Isabelle, Ph.D ; Voets, Willy, M.D., Ph.D ; Galjaard, Sander, M.D ; Van Haard, Paul M.M., Ph.D ; Vansant, Greet M., Ph.D ; Devlieger, Roland, M.D., Ph.D</creator><creatorcontrib>Jans, Goele, M.S ; Guelinckx, Isabelle, Ph.D ; Voets, Willy, M.D., Ph.D ; Galjaard, Sander, M.D ; Van Haard, Paul M.M., Ph.D ; Vansant, Greet M., Ph.D ; Devlieger, Roland, M.D., Ph.D</creatorcontrib><description>Abstract Background Neonatal intracranial bleedings and birth defects have been reported, possibly related to maternal vitamin K1 deficiency during pregnancy after bariatric surgery. The objective of this study was to investigate the effects of screening and supplementation on K1 serum levels in pregnant women with bariatric surgery, and to compare K1 levels and prothrombin time (PT %) in the first trimester with pregnant women without bariatric surgery. Methods A prospective cohort study including 49 pregnant women with bariatric surgery. Nutritional deficiencies were prospectively screened. In case of observed low K1 serum levels, supplementation was provided. K1 serum levels and PT (%) during the first trimester were compared with a nonsurgical control group of 27 women. Results During the first trimester, most women had low K1 serum levels (<0.8 nmol/l). Mean vitamin K1 levels were significantly lower in the surgical group compared to the nonsurgical control group (.44 versus .64 nmol/l; P = .016). PT (%) remained in the normal range, The surgery group showed a higher mean PT compared to the controls (111.3 versus 98.9%; P <.001) Mean K1 serum levels in the study group were higher during the third than during the first trimester ( P = .014). PT (%) was significantly higher during the second and third than during the first trimester ( P = .004). Most of the coagulation factors, including II, V, VII, IX, and X, remained within normal ranges. Conclusion Low circulating K1 appears to be common in pregnant women with and without bariatric surgery. Supplementation during pregnancy can restore vitamin K1 in women with bariatric surgery, potentially protecting the fetus and newborn against intracranial hemorrhage.</description><identifier>ISSN: 1550-7289</identifier><identifier>EISSN: 1878-7533</identifier><identifier>DOI: 10.1016/j.soard.2014.04.032</identifier><identifier>PMID: 25264330</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Bariatric surgery ; Bariatric Surgery - adverse effects ; Case-Control Studies ; Dietary Supplements ; Female ; Gastroenterology and Hepatology ; Humans ; Obesity - surgery ; Pregnancy ; Pregnancy Complications, Hematologic - etiology ; Pregnancy Complications, Hematologic - prevention & control ; Prenatal Diagnosis ; Prospective Studies ; Surgery ; Vitamin K 1 - administration & dosage ; Vitamin K 1 - metabolism ; Vitamin K Deficiency - etiology ; Vitamin K Deficiency - prevention & control ; Vitamin K1 ; Vitamins - administration & dosage ; Young Adult</subject><ispartof>Surgery for obesity and related diseases, 2014-09, Vol.10 (5), p.885-890</ispartof><rights>American Society for Bariatric Surgery</rights><rights>2014 American Society for Bariatric Surgery</rights><rights>Copyright © 2014 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-fa6fb90a56e179f3ab9b2b1449a549fe4361f437f095d741bc2717a84b6f64163</citedby><cites>FETCH-LOGICAL-c414t-fa6fb90a56e179f3ab9b2b1449a549fe4361f437f095d741bc2717a84b6f64163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1550728914002147$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25264330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jans, Goele, M.S</creatorcontrib><creatorcontrib>Guelinckx, Isabelle, Ph.D</creatorcontrib><creatorcontrib>Voets, Willy, M.D., Ph.D</creatorcontrib><creatorcontrib>Galjaard, Sander, M.D</creatorcontrib><creatorcontrib>Van Haard, Paul M.M., Ph.D</creatorcontrib><creatorcontrib>Vansant, Greet M., Ph.D</creatorcontrib><creatorcontrib>Devlieger, Roland, M.D., Ph.D</creatorcontrib><title>Vitamin K1 monitoring in pregnancies after bariatric surgery: a prospective cohort study</title><title>Surgery for obesity and related diseases</title><addtitle>Surg Obes Relat Dis</addtitle><description>Abstract Background Neonatal intracranial bleedings and birth defects have been reported, possibly related to maternal vitamin K1 deficiency during pregnancy after bariatric surgery. The objective of this study was to investigate the effects of screening and supplementation on K1 serum levels in pregnant women with bariatric surgery, and to compare K1 levels and prothrombin time (PT %) in the first trimester with pregnant women without bariatric surgery. Methods A prospective cohort study including 49 pregnant women with bariatric surgery. Nutritional deficiencies were prospectively screened. In case of observed low K1 serum levels, supplementation was provided. K1 serum levels and PT (%) during the first trimester were compared with a nonsurgical control group of 27 women. Results During the first trimester, most women had low K1 serum levels (<0.8 nmol/l). Mean vitamin K1 levels were significantly lower in the surgical group compared to the nonsurgical control group (.44 versus .64 nmol/l; P = .016). PT (%) remained in the normal range, The surgery group showed a higher mean PT compared to the controls (111.3 versus 98.9%; P <.001) Mean K1 serum levels in the study group were higher during the third than during the first trimester ( P = .014). PT (%) was significantly higher during the second and third than during the first trimester ( P = .004). Most of the coagulation factors, including II, V, VII, IX, and X, remained within normal ranges. Conclusion Low circulating K1 appears to be common in pregnant women with and without bariatric surgery. Supplementation during pregnancy can restore vitamin K1 in women with bariatric surgery, potentially protecting the fetus and newborn against intracranial hemorrhage.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bariatric surgery</subject><subject>Bariatric Surgery - adverse effects</subject><subject>Case-Control Studies</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Obesity - surgery</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Hematologic - etiology</subject><subject>Pregnancy Complications, Hematologic - prevention & control</subject><subject>Prenatal Diagnosis</subject><subject>Prospective Studies</subject><subject>Surgery</subject><subject>Vitamin K 1 - administration & dosage</subject><subject>Vitamin K 1 - metabolism</subject><subject>Vitamin K Deficiency - etiology</subject><subject>Vitamin K Deficiency - prevention & control</subject><subject>Vitamin K1</subject><subject>Vitamins - administration & dosage</subject><subject>Young Adult</subject><issn>1550-7289</issn><issn>1878-7533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7of-AkH66KXHVJJOJoKCLLsqLuzBD7yFdLoyZuxOj0l6Yf79ZpzVg5eFggrF-6aqniLkBdAVUJCvt6s82zSsGAWxojU4e0ROYa3Wreo4f1zfXUdbxdb6hJzlvKWUy06xp-SEdUwKzukp-fE9FDuF2HyGZppjKHMKcdPUwi7hJtroAubG-oKp6W0KtqTgmrykDab9m8ZW2Zx36Eq4xcbNP-dUmlyWYf-MPPF2zPj8Pp-Tb1eXXy8-ttc3Hz5dvL9unQBRWm-l7zW1nURQ2nPb6571IIS2ndAeBZfgBVee6m5QAnrHFCi7Fr30UoDk5-TV8d86yO8FczFTyA7H0Uacl2xAMq2lVqCrlB-lrs6cE3qzS2GyaW-AmgNSszV_kJoDUkNrcFZdL-8bLP2Ewz_PX4ZV8PYowLrmbcBkcoUWHQ4hVTBmmMMDDd7953djiMHZ8RfuMW_nJcVK0IDJzFDz5XDVw1FBUMpAKH4HP1-dtg</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Jans, Goele, M.S</creator><creator>Guelinckx, Isabelle, Ph.D</creator><creator>Voets, Willy, M.D., Ph.D</creator><creator>Galjaard, Sander, M.D</creator><creator>Van Haard, Paul M.M., Ph.D</creator><creator>Vansant, Greet M., Ph.D</creator><creator>Devlieger, Roland, M.D., Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Vitamin K1 monitoring in pregnancies after bariatric surgery: a prospective cohort study</title><author>Jans, Goele, M.S ; Guelinckx, Isabelle, Ph.D ; Voets, Willy, M.D., Ph.D ; Galjaard, Sander, M.D ; Van Haard, Paul M.M., Ph.D ; Vansant, Greet M., Ph.D ; Devlieger, Roland, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-fa6fb90a56e179f3ab9b2b1449a549fe4361f437f095d741bc2717a84b6f64163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bariatric surgery</topic><topic>Bariatric Surgery - adverse effects</topic><topic>Case-Control Studies</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Obesity - surgery</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Hematologic - etiology</topic><topic>Pregnancy Complications, Hematologic - prevention & control</topic><topic>Prenatal Diagnosis</topic><topic>Prospective Studies</topic><topic>Surgery</topic><topic>Vitamin K 1 - administration & dosage</topic><topic>Vitamin K 1 - metabolism</topic><topic>Vitamin K Deficiency - etiology</topic><topic>Vitamin K Deficiency - prevention & control</topic><topic>Vitamin K1</topic><topic>Vitamins - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jans, Goele, M.S</creatorcontrib><creatorcontrib>Guelinckx, Isabelle, Ph.D</creatorcontrib><creatorcontrib>Voets, Willy, M.D., Ph.D</creatorcontrib><creatorcontrib>Galjaard, Sander, M.D</creatorcontrib><creatorcontrib>Van Haard, Paul M.M., Ph.D</creatorcontrib><creatorcontrib>Vansant, Greet M., Ph.D</creatorcontrib><creatorcontrib>Devlieger, Roland, M.D., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery for obesity and related diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jans, Goele, M.S</au><au>Guelinckx, Isabelle, Ph.D</au><au>Voets, Willy, M.D., Ph.D</au><au>Galjaard, Sander, M.D</au><au>Van Haard, Paul M.M., Ph.D</au><au>Vansant, Greet M., Ph.D</au><au>Devlieger, Roland, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin K1 monitoring in pregnancies after bariatric surgery: a prospective cohort study</atitle><jtitle>Surgery for obesity and related diseases</jtitle><addtitle>Surg Obes Relat Dis</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>10</volume><issue>5</issue><spage>885</spage><epage>890</epage><pages>885-890</pages><issn>1550-7289</issn><eissn>1878-7533</eissn><abstract>Abstract Background Neonatal intracranial bleedings and birth defects have been reported, possibly related to maternal vitamin K1 deficiency during pregnancy after bariatric surgery. The objective of this study was to investigate the effects of screening and supplementation on K1 serum levels in pregnant women with bariatric surgery, and to compare K1 levels and prothrombin time (PT %) in the first trimester with pregnant women without bariatric surgery. Methods A prospective cohort study including 49 pregnant women with bariatric surgery. Nutritional deficiencies were prospectively screened. In case of observed low K1 serum levels, supplementation was provided. K1 serum levels and PT (%) during the first trimester were compared with a nonsurgical control group of 27 women. Results During the first trimester, most women had low K1 serum levels (<0.8 nmol/l). Mean vitamin K1 levels were significantly lower in the surgical group compared to the nonsurgical control group (.44 versus .64 nmol/l; P = .016). PT (%) remained in the normal range, The surgery group showed a higher mean PT compared to the controls (111.3 versus 98.9%; P <.001) Mean K1 serum levels in the study group were higher during the third than during the first trimester ( P = .014). PT (%) was significantly higher during the second and third than during the first trimester ( P = .004). Most of the coagulation factors, including II, V, VII, IX, and X, remained within normal ranges. Conclusion Low circulating K1 appears to be common in pregnant women with and without bariatric surgery. Supplementation during pregnancy can restore vitamin K1 in women with bariatric surgery, potentially protecting the fetus and newborn against intracranial hemorrhage.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25264330</pmid><doi>10.1016/j.soard.2014.04.032</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Bariatric surgery Bariatric Surgery - adverse effects Case-Control Studies Dietary Supplements Female Gastroenterology and Hepatology Humans Obesity - surgery Pregnancy Pregnancy Complications, Hematologic - etiology Pregnancy Complications, Hematologic - prevention & control Prenatal Diagnosis Prospective Studies Surgery Vitamin K 1 - administration & dosage Vitamin K 1 - metabolism Vitamin K Deficiency - etiology Vitamin K Deficiency - prevention & control Vitamin K1 Vitamins - administration & dosage Young Adult |
| title | Vitamin K1 monitoring in pregnancies after bariatric surgery: a prospective cohort study |
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