The Effect of Infrequent Low-Dose Rosuvastatin on the Lipid Profile
Abstract We retrospectively studied 21 patients who had difficulty tolerating daily or alternating-day statins. Patients received rosuvastatin at a mean frequency of 1.7 doses per week, and a mean dose of 11.7 mg per week. We assessed lipid profiles at baseline and after at least 3 months of therapy...
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| Veröffentlicht in: | Canadian journal of cardiology 2014-11, Vol.30 (11), p.1392-1395 |
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| container_title | Canadian journal of cardiology |
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| creator | Ibrahim, Christine, MD Ban, Matthew R., BSc Hegele, Robert A., MD |
| description | Abstract We retrospectively studied 21 patients who had difficulty tolerating daily or alternating-day statins. Patients received rosuvastatin at a mean frequency of 1.7 doses per week, and a mean dose of 11.7 mg per week. We assessed lipid profiles at baseline and after at least 3 months of therapy. We found that total and low-density lipoprotein cholesterol were reduced by 2.03 ± 2.04 and 1.31 ± 0.83 mmol/L (27.9% and 31.5%), respectively, from baseline (both P < 0.001). Thus, in patients with statin intolerance, infrequent low-dose rosuvastatin significantly improved low-density lipoprotein cholesterol and was well tolerated over the long term. |
| doi_str_mv | 10.1016/j.cjca.2014.07.002 |
| format | Article |
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Patients received rosuvastatin at a mean frequency of 1.7 doses per week, and a mean dose of 11.7 mg per week. We assessed lipid profiles at baseline and after at least 3 months of therapy. We found that total and low-density lipoprotein cholesterol were reduced by 2.03 ± 2.04 and 1.31 ± 0.83 mmol/L (27.9% and 31.5%), respectively, from baseline (both P < 0.001). Thus, in patients with statin intolerance, infrequent low-dose rosuvastatin significantly improved low-density lipoprotein cholesterol and was well tolerated over the long term.</description><identifier>ISSN: 0828-282X</identifier><identifier>EISSN: 1916-7075</identifier><identifier>DOI: 10.1016/j.cjca.2014.07.002</identifier><identifier>PMID: 25442436</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Administration, Oral ; Aged ; Aged, 80 and over ; Cardiovascular ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - prevention & control ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Fluorobenzenes - administration & dosage ; Follow-Up Studies ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Lipids - blood ; Male ; Middle Aged ; Pyrimidines - administration & dosage ; Retrospective Studies ; Rosuvastatin Calcium ; Sulfonamides - administration & dosage ; Treatment Outcome</subject><ispartof>Canadian journal of cardiology, 2014-11, Vol.30 (11), p.1392-1395</ispartof><rights>Canadian Cardiovascular Society</rights><rights>2014 Canadian Cardiovascular Society</rights><rights>Copyright © 2014 Canadian Cardiovascular Society. 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Patients received rosuvastatin at a mean frequency of 1.7 doses per week, and a mean dose of 11.7 mg per week. We assessed lipid profiles at baseline and after at least 3 months of therapy. We found that total and low-density lipoprotein cholesterol were reduced by 2.03 ± 2.04 and 1.31 ± 0.83 mmol/L (27.9% and 31.5%), respectively, from baseline (both P < 0.001). Thus, in patients with statin intolerance, infrequent low-dose rosuvastatin significantly improved low-density lipoprotein cholesterol and was well tolerated over the long term.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiovascular</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Fluorobenzenes - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pyrimidines - administration & dosage</subject><subject>Retrospective Studies</subject><subject>Rosuvastatin Calcium</subject><subject>Sulfonamides - administration & dosage</subject><subject>Treatment Outcome</subject><issn>0828-282X</issn><issn>1916-7075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1K5TAYhsOgjEedG3AxdOmmNV_apj0wDIj_cEDxB2YX0uQLptPTHJNW8W68Fq_MlKMuXLjK5n1evjwvIXtAM6DAD9pMtUpmjEKR0SqjlP0gM5gDTytalRtkRmtWp6xm_7bIdggtpQVUFf9JtlhZFKzI-Ywc395jcmIMqiFxJrnojceHEfshWbin9NgFTK5dGB9lGORg-8T1yRCJhV1Z_fpy5Z2xHe6STSO7gL_e3x1yd3pye3SeLi7PLo4OF6liczakuqg456gln3OupcqbsgE0EiqjGUDTSNY0KDkY0AZQUprnuTKc11znjWH5Dtlf9668i0eGQSxtUNh1skc3BgGczWN1WU9Rto4q70LwaMTK26X0zwKomOyJVkz2xGRP0EpEexH6_d4_NkvUn8iHrhj4sw5g_OWjRS-Cstgr1NZHg0I7-33_3y-46mxvlez-4zOG1o2-j_4EiMAEFTfTftN8UMTpSl7mbyxfljQ</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Ibrahim, Christine, MD</creator><creator>Ban, Matthew R., BSc</creator><creator>Hegele, Robert A., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9092-604X</orcidid></search><sort><creationdate>20141101</creationdate><title>The Effect of Infrequent Low-Dose Rosuvastatin on the Lipid Profile</title><author>Ibrahim, Christine, MD ; Ban, Matthew R., BSc ; Hegele, Robert A., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-d47666eda6966dac3b5b1efa17fd211bba2bbea61f1df1ea00333cf6686d3bf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiovascular</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Fluorobenzenes - administration & dosage</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pyrimidines - administration & dosage</topic><topic>Retrospective Studies</topic><topic>Rosuvastatin Calcium</topic><topic>Sulfonamides - administration & dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ibrahim, Christine, MD</creatorcontrib><creatorcontrib>Ban, Matthew R., BSc</creatorcontrib><creatorcontrib>Hegele, Robert A., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibrahim, Christine, MD</au><au>Ban, Matthew R., BSc</au><au>Hegele, Robert A., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Infrequent Low-Dose Rosuvastatin on the Lipid Profile</atitle><jtitle>Canadian journal of cardiology</jtitle><addtitle>Can J Cardiol</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>30</volume><issue>11</issue><spage>1392</spage><epage>1395</epage><pages>1392-1395</pages><issn>0828-282X</issn><eissn>1916-7075</eissn><abstract>Abstract We retrospectively studied 21 patients who had difficulty tolerating daily or alternating-day statins. Patients received rosuvastatin at a mean frequency of 1.7 doses per week, and a mean dose of 11.7 mg per week. We assessed lipid profiles at baseline and after at least 3 months of therapy. We found that total and low-density lipoprotein cholesterol were reduced by 2.03 ± 2.04 and 1.31 ± 0.83 mmol/L (27.9% and 31.5%), respectively, from baseline (both P < 0.001). Thus, in patients with statin intolerance, infrequent low-dose rosuvastatin significantly improved low-density lipoprotein cholesterol and was well tolerated over the long term.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>25442436</pmid><doi>10.1016/j.cjca.2014.07.002</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-9092-604X</orcidid></addata></record> |
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| language | eng |
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| subjects | Administration, Oral Aged Aged, 80 and over Cardiovascular Cardiovascular Diseases - blood Cardiovascular Diseases - prevention & control Dose-Response Relationship, Drug Drug Administration Schedule Female Fluorobenzenes - administration & dosage Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Lipids - blood Male Middle Aged Pyrimidines - administration & dosage Retrospective Studies Rosuvastatin Calcium Sulfonamides - administration & dosage Treatment Outcome |
| title | The Effect of Infrequent Low-Dose Rosuvastatin on the Lipid Profile |
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