Medication Safety: Does Intravenous Acetaminophen Promote Perioperative Hypothermia for Total Hip Arthroplasty?
Abstract As an effective antipyretic with a yet-unknown mechanism-of-action, intravenous (IV) acetaminophen use for total hip arthroplasties (THA) may worsen perioperative hypothermia when combined with the known hypothermia-inducing effects of general anesthesia (GA), affecting wound healing, recov...
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| Veröffentlicht in: | The Journal of arthroplasty 2014-11, Vol.29 (11), p.2230-2232 |
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| container_title | The Journal of arthroplasty |
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| creator | Visnjevac, Ognjen, MD Kocz, Remek, MD Visnjevac, Tanja, RN, MScN Annam, Sandeep Kumar, MD Toufexis, George, MD |
| description | Abstract As an effective antipyretic with a yet-unknown mechanism-of-action, intravenous (IV) acetaminophen use for total hip arthroplasties (THA) may worsen perioperative hypothermia when combined with the known hypothermia-inducing effects of general anesthesia (GA), affecting wound healing, recovery times, and patient satisfaction. This retrospective chart review of primary THA cases compared perioperative heat loss for patients who received IV acetaminophen with GA (group A, n = 74) to those receiving GA alone (group B, n = 197). All patients received forced-air warming blankets. Neuraxial anesthesia cases were excluded. No significant temperature differences existed between group A (–0.33°C, SD = 0.36) and group B (–0.30°C, SD = 0.34, P > 0.05). IV acetaminophen use for THA does not appear to promote hypothermia under general anesthesia. |
| doi_str_mv | 10.1016/j.arth.2014.06.027 |
| format | Article |
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This retrospective chart review of primary THA cases compared perioperative heat loss for patients who received IV acetaminophen with GA (group A, n = 74) to those receiving GA alone (group B, n = 197). All patients received forced-air warming blankets. Neuraxial anesthesia cases were excluded. No significant temperature differences existed between group A (–0.33°C, SD = 0.36) and group B (–0.30°C, SD = 0.34, P > 0.05). 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This retrospective chart review of primary THA cases compared perioperative heat loss for patients who received IV acetaminophen with GA (group A, n = 74) to those receiving GA alone (group B, n = 197). All patients received forced-air warming blankets. Neuraxial anesthesia cases were excluded. No significant temperature differences existed between group A (–0.33°C, SD = 0.36) and group B (–0.30°C, SD = 0.34, P > 0.05). IV acetaminophen use for THA does not appear to promote hypothermia under general anesthesia.</description><subject>acetaminophen</subject><subject>Acetaminophen - administration & dosage</subject><subject>Acetaminophen - adverse effects</subject><subject>Administration, Intravenous</subject><subject>Aged</subject><subject>Anesthesia, General - adverse effects</subject><subject>Arthroplasty, Replacement, Hip</subject><subject>Female</subject><subject>general anesthesia</subject><subject>Humans</subject><subject>hypothermia</subject><subject>Hypothermia - chemically induced</subject><subject>Hypothermia - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>patient satisfaction</subject><subject>Retrospective Studies</subject><subject>total hip arthroplasty</subject><issn>0883-5403</issn><issn>1532-8406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhS0EokPhD7BAXrJJuI4fkyAEGpXHVCqiUsvacjw3Gg9JnNqekfLvcTSFBQtWd3PO0T3fIeQ1g5IBU-8OpQlpX1bARAmqhGr9hKyY5FVRC1BPyQrqmhdSAL8gL2I8ADAmpXhOLirJgAslV8R_x52zJjk_0jvTYZrf088eI70eUzAnHP0x0o3FZAY3-mmPI70NfvAJ6S0G5ycM2XxCup0nn_YYBmdo5wO998n0dOsmuslPBj_1Jqb500vyrDN9xFeP95L8_Prl_mpb3Pz4dn21uSmsqFkqVLdrc581h7bla2lYK5WSjegqKyphpQRjhJA1t0p1suWmMQJZB41Abmo0_JK8PedOwT8cMSY9uGix782IuZJmqmqanLjmWVqdpTb4GAN2egpuMGHWDPQCWh_0AlovoDUonR_LpjeP-cd2wN1fyx-yWfDhLMDc8uQw6GgdjjbjDmiT3nn3__yP_9ht78a8VP8LZ4wHfwxj5qeZjpUGfbdMvSzNBIDgUvLfBu6lPw</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Visnjevac, Ognjen, MD</creator><creator>Kocz, Remek, MD</creator><creator>Visnjevac, Tanja, RN, MScN</creator><creator>Annam, Sandeep Kumar, MD</creator><creator>Toufexis, George, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9945-2191</orcidid><orcidid>https://orcid.org/0000-0002-8105-5614</orcidid></search><sort><creationdate>20141101</creationdate><title>Medication Safety: Does Intravenous Acetaminophen Promote Perioperative Hypothermia for Total Hip Arthroplasty?</title><author>Visnjevac, Ognjen, MD ; Kocz, Remek, MD ; Visnjevac, Tanja, RN, MScN ; Annam, Sandeep Kumar, MD ; Toufexis, George, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-6fdb027730bb375a1b566594f2c424c550aa44583c66f5b3a9a4e1f094e3a8ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>acetaminophen</topic><topic>Acetaminophen - administration & dosage</topic><topic>Acetaminophen - adverse effects</topic><topic>Administration, Intravenous</topic><topic>Aged</topic><topic>Anesthesia, General - adverse effects</topic><topic>Arthroplasty, Replacement, Hip</topic><topic>Female</topic><topic>general anesthesia</topic><topic>Humans</topic><topic>hypothermia</topic><topic>Hypothermia - chemically induced</topic><topic>Hypothermia - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>patient satisfaction</topic><topic>Retrospective Studies</topic><topic>total hip arthroplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visnjevac, Ognjen, MD</creatorcontrib><creatorcontrib>Kocz, Remek, MD</creatorcontrib><creatorcontrib>Visnjevac, Tanja, RN, MScN</creatorcontrib><creatorcontrib>Annam, Sandeep Kumar, MD</creatorcontrib><creatorcontrib>Toufexis, George, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of arthroplasty</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visnjevac, Ognjen, MD</au><au>Kocz, Remek, MD</au><au>Visnjevac, Tanja, RN, MScN</au><au>Annam, Sandeep Kumar, MD</au><au>Toufexis, George, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medication Safety: Does Intravenous Acetaminophen Promote Perioperative Hypothermia for Total Hip Arthroplasty?</atitle><jtitle>The Journal of arthroplasty</jtitle><addtitle>J Arthroplasty</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>29</volume><issue>11</issue><spage>2230</spage><epage>2232</epage><pages>2230-2232</pages><issn>0883-5403</issn><eissn>1532-8406</eissn><abstract>Abstract As an effective antipyretic with a yet-unknown mechanism-of-action, intravenous (IV) acetaminophen use for total hip arthroplasties (THA) may worsen perioperative hypothermia when combined with the known hypothermia-inducing effects of general anesthesia (GA), affecting wound healing, recovery times, and patient satisfaction. This retrospective chart review of primary THA cases compared perioperative heat loss for patients who received IV acetaminophen with GA (group A, n = 74) to those receiving GA alone (group B, n = 197). All patients received forced-air warming blankets. Neuraxial anesthesia cases were excluded. No significant temperature differences existed between group A (–0.33°C, SD = 0.36) and group B (–0.30°C, SD = 0.34, P > 0.05). IV acetaminophen use for THA does not appear to promote hypothermia under general anesthesia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25103465</pmid><doi>10.1016/j.arth.2014.06.027</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-9945-2191</orcidid><orcidid>https://orcid.org/0000-0002-8105-5614</orcidid></addata></record> |
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| subjects | acetaminophen Acetaminophen - administration & dosage Acetaminophen - adverse effects Administration, Intravenous Aged Anesthesia, General - adverse effects Arthroplasty, Replacement, Hip Female general anesthesia Humans hypothermia Hypothermia - chemically induced Hypothermia - etiology Male Middle Aged Orthopedics patient satisfaction Retrospective Studies total hip arthroplasty |
| title | Medication Safety: Does Intravenous Acetaminophen Promote Perioperative Hypothermia for Total Hip Arthroplasty? |
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