Experimental titanium alloys for dental applications

Statement of problem Although the use of titanium has increased, casting difficulties limit routine use. Purpose The purpose of the present study was to compare the mechanical properties and biocompatibility of the experimental titanium alloys titanium–5-zirconium, titanium–5-tantalum, and titanium–...

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Veröffentlicht in:The Journal of prosthetic dentistry 2014-12, Vol.112 (6), p.1448-1460
Hauptverfasser: Faria, Adriana C.L., DDS, MSc, PhD, Rodrigues, Renata C.S., DDS, MSc, PhD, Rosa, Adalberto L., DDS, MSc, PhD, Ribeiro, Ricardo F., DDS, MSc, PhD
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container_end_page 1460
container_issue 6
container_start_page 1448
container_title The Journal of prosthetic dentistry
container_volume 112
creator Faria, Adriana C.L., DDS, MSc, PhD
Rodrigues, Renata C.S., DDS, MSc, PhD
Rosa, Adalberto L., DDS, MSc, PhD
Ribeiro, Ricardo F., DDS, MSc, PhD
description Statement of problem Although the use of titanium has increased, casting difficulties limit routine use. Purpose The purpose of the present study was to compare the mechanical properties and biocompatibility of the experimental titanium alloys titanium–5-zirconium, titanium–5-tantalum, and titanium–5-tantalum–5-zirconium (in wt%) with those of commercially pure titanium. Material and methods Specimens of titanium alloys and commercially pure titanium were cast by using plasma. Their modulus of elasticity and ultimate tensile strength were determined in a universal testing machine. Biocompatibility was evaluated with SCC9 cells. In periods of 1, 4, 7, 10, and 14 days, cell proliferation was evaluated by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay, and cell viability was evaluated in the 7-day period. Cell morphology was evaluated at 2, 12, and 24 hours. Modulus of elasticity, ultimate tensile strength, and cell viability were analyzed by 1-way ANOVA and the Bonferroni test; cell proliferation data were compared by 2-way ANOVA (alloy versus time) and by the Bonferroni test; and the cell morphology data were analyzed by split-plot design. All statistical tests were performed at the 95% confidence level ( P
doi_str_mv 10.1016/j.prosdent.2013.12.025
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Purpose The purpose of the present study was to compare the mechanical properties and biocompatibility of the experimental titanium alloys titanium–5-zirconium, titanium–5-tantalum, and titanium–5-tantalum–5-zirconium (in wt%) with those of commercially pure titanium. Material and methods Specimens of titanium alloys and commercially pure titanium were cast by using plasma. Their modulus of elasticity and ultimate tensile strength were determined in a universal testing machine. Biocompatibility was evaluated with SCC9 cells. In periods of 1, 4, 7, 10, and 14 days, cell proliferation was evaluated by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay, and cell viability was evaluated in the 7-day period. Cell morphology was evaluated at 2, 12, and 24 hours. Modulus of elasticity, ultimate tensile strength, and cell viability were analyzed by 1-way ANOVA and the Bonferroni test; cell proliferation data were compared by 2-way ANOVA (alloy versus time) and by the Bonferroni test; and the cell morphology data were analyzed by split-plot design. All statistical tests were performed at the 95% confidence level ( P &lt;.05). Results Titanium–5-tantalum presented the lowest modulus of elasticity and ultimate tensile strength, whereas titanium–5-zirconium and titanium–5-tantalum–5-zirconium were statistically similar to commercially pure titanium. Cell proliferation and viability were not affected by any alloy being similar to those observed for commercially pure titanium. No noticeably differences were found in the morphology of cells cultured on any alloy and commercially pure titanium. Conclusion Experimental alloys, especially titanium–5-zirconium and titanium–5-tantalum–5-zirconium, presented promising mechanical results for future studies and clinical applications. In addition, these alloys, evaluated by cell proliferation, viability, and morphology, were found to be biocompatible in vitro.</description><identifier>ISSN: 0022-3913</identifier><identifier>EISSN: 1097-6841</identifier><identifier>DOI: 10.1016/j.prosdent.2013.12.025</identifier><identifier>PMID: 25088209</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alloys - chemistry ; Alloys - pharmacology ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Shape - drug effects ; Cell Survival - drug effects ; Dental Alloys - chemistry ; Dental Alloys - pharmacology ; Dental Casting Technique ; Dental Materials - chemistry ; Dental Materials - pharmacology ; Dental Stress Analysis - instrumentation ; Dentistry ; Elastic Modulus ; Humans ; Materials Testing ; Mechanical Phenomena ; Microscopy, Electron, Scanning ; Plasma Gases ; Pliability ; Tantalum - chemistry ; Tantalum - pharmacology ; Tensile Strength ; Tetrazolium Salts ; Thiazoles ; Time Factors ; Titanium - chemistry ; Titanium - pharmacology</subject><ispartof>The Journal of prosthetic dentistry, 2014-12, Vol.112 (6), p.1448-1460</ispartof><rights>Editorial Council for the Journal of Prosthetic Dentistry</rights><rights>2014 Editorial Council for the Journal of Prosthetic Dentistry</rights><rights>Copyright © 2014 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-2ca860e209132f4923a0d0cff1fb845996505851c35802ff629399f404010d983</citedby><cites>FETCH-LOGICAL-c423t-2ca860e209132f4923a0d0cff1fb845996505851c35802ff629399f404010d983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.prosdent.2013.12.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25088209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faria, Adriana C.L., DDS, MSc, PhD</creatorcontrib><creatorcontrib>Rodrigues, Renata C.S., DDS, MSc, PhD</creatorcontrib><creatorcontrib>Rosa, Adalberto L., DDS, MSc, PhD</creatorcontrib><creatorcontrib>Ribeiro, Ricardo F., DDS, MSc, PhD</creatorcontrib><title>Experimental titanium alloys for dental applications</title><title>The Journal of prosthetic dentistry</title><addtitle>J Prosthet Dent</addtitle><description>Statement of problem Although the use of titanium has increased, casting difficulties limit routine use. Purpose The purpose of the present study was to compare the mechanical properties and biocompatibility of the experimental titanium alloys titanium–5-zirconium, titanium–5-tantalum, and titanium–5-tantalum–5-zirconium (in wt%) with those of commercially pure titanium. Material and methods Specimens of titanium alloys and commercially pure titanium were cast by using plasma. Their modulus of elasticity and ultimate tensile strength were determined in a universal testing machine. Biocompatibility was evaluated with SCC9 cells. In periods of 1, 4, 7, 10, and 14 days, cell proliferation was evaluated by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay, and cell viability was evaluated in the 7-day period. Cell morphology was evaluated at 2, 12, and 24 hours. Modulus of elasticity, ultimate tensile strength, and cell viability were analyzed by 1-way ANOVA and the Bonferroni test; cell proliferation data were compared by 2-way ANOVA (alloy versus time) and by the Bonferroni test; and the cell morphology data were analyzed by split-plot design. All statistical tests were performed at the 95% confidence level ( P &lt;.05). Results Titanium–5-tantalum presented the lowest modulus of elasticity and ultimate tensile strength, whereas titanium–5-zirconium and titanium–5-tantalum–5-zirconium were statistically similar to commercially pure titanium. Cell proliferation and viability were not affected by any alloy being similar to those observed for commercially pure titanium. No noticeably differences were found in the morphology of cells cultured on any alloy and commercially pure titanium. Conclusion Experimental alloys, especially titanium–5-zirconium and titanium–5-tantalum–5-zirconium, presented promising mechanical results for future studies and clinical applications. In addition, these alloys, evaluated by cell proliferation, viability, and morphology, were found to be biocompatible in vitro.</description><subject>Alloys - chemistry</subject><subject>Alloys - pharmacology</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Shape - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Dental Alloys - chemistry</subject><subject>Dental Alloys - pharmacology</subject><subject>Dental Casting Technique</subject><subject>Dental Materials - chemistry</subject><subject>Dental Materials - pharmacology</subject><subject>Dental Stress Analysis - instrumentation</subject><subject>Dentistry</subject><subject>Elastic Modulus</subject><subject>Humans</subject><subject>Materials Testing</subject><subject>Mechanical Phenomena</subject><subject>Microscopy, Electron, Scanning</subject><subject>Plasma Gases</subject><subject>Pliability</subject><subject>Tantalum - chemistry</subject><subject>Tantalum - pharmacology</subject><subject>Tensile Strength</subject><subject>Tetrazolium Salts</subject><subject>Thiazoles</subject><subject>Time Factors</subject><subject>Titanium - chemistry</subject><subject>Titanium - pharmacology</subject><issn>0022-3913</issn><issn>1097-6841</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1OwzAQhC0EoqXwClWPXBJ27SS1LwhUlR-pEgdA4ma5ji25uEmIE0TfHkelHLhw8kqemdV8S8gUIUXA4mqTNm0dSlN1KQVkKdIUaH5ExghinhQ8w2MyBqA0YQLZiJyFsAEAns_xlIxoDpxTEGOSLb8a07ptDFJ-1rlOVa7fzpT39S7MbN3Oyv2XahrvtOpcXYVzcmKVD-bi552Q17vly-IhWT3dPy5uV4nOKOsSqhUvwMQ9yKjNBGUKStDWol3zLBeiyCHnOWqWc6DWFlQwIWwGGSCUgrMJudznxq4fvQmd3LqgjfeqMnUfJEaHKGIwRGmxl-qIJbTGyia2Uu1OIsiBmNzIAzE5EJNIZSQWjdOfHf16a8pf2wFRFNzsBSY2_XSmlUE7U2lTutboTpa1-3_H9Z8I7V0Vafp3szNhU_dtFTlKlCEa5PNwt-FsmMWJz9_YN9W_k4U</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Faria, Adriana C.L., DDS, MSc, PhD</creator><creator>Rodrigues, Renata C.S., DDS, MSc, PhD</creator><creator>Rosa, Adalberto L., DDS, MSc, PhD</creator><creator>Ribeiro, Ricardo F., DDS, MSc, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>Experimental titanium alloys for dental applications</title><author>Faria, Adriana C.L., DDS, MSc, PhD ; Rodrigues, Renata C.S., DDS, MSc, PhD ; Rosa, Adalberto L., DDS, MSc, PhD ; Ribeiro, Ricardo F., DDS, MSc, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-2ca860e209132f4923a0d0cff1fb845996505851c35802ff629399f404010d983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alloys - chemistry</topic><topic>Alloys - pharmacology</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Shape - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Dental Alloys - chemistry</topic><topic>Dental Alloys - pharmacology</topic><topic>Dental Casting Technique</topic><topic>Dental Materials - chemistry</topic><topic>Dental Materials - pharmacology</topic><topic>Dental Stress Analysis - instrumentation</topic><topic>Dentistry</topic><topic>Elastic Modulus</topic><topic>Humans</topic><topic>Materials Testing</topic><topic>Mechanical Phenomena</topic><topic>Microscopy, Electron, Scanning</topic><topic>Plasma Gases</topic><topic>Pliability</topic><topic>Tantalum - chemistry</topic><topic>Tantalum - pharmacology</topic><topic>Tensile Strength</topic><topic>Tetrazolium Salts</topic><topic>Thiazoles</topic><topic>Time Factors</topic><topic>Titanium - chemistry</topic><topic>Titanium - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faria, Adriana C.L., DDS, MSc, PhD</creatorcontrib><creatorcontrib>Rodrigues, Renata C.S., DDS, MSc, PhD</creatorcontrib><creatorcontrib>Rosa, Adalberto L., DDS, MSc, PhD</creatorcontrib><creatorcontrib>Ribeiro, Ricardo F., DDS, MSc, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of prosthetic dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faria, Adriana C.L., DDS, MSc, PhD</au><au>Rodrigues, Renata C.S., DDS, MSc, PhD</au><au>Rosa, Adalberto L., DDS, MSc, PhD</au><au>Ribeiro, Ricardo F., DDS, MSc, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental titanium alloys for dental applications</atitle><jtitle>The Journal of prosthetic dentistry</jtitle><addtitle>J Prosthet Dent</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>112</volume><issue>6</issue><spage>1448</spage><epage>1460</epage><pages>1448-1460</pages><issn>0022-3913</issn><eissn>1097-6841</eissn><abstract>Statement of problem Although the use of titanium has increased, casting difficulties limit routine use. Purpose The purpose of the present study was to compare the mechanical properties and biocompatibility of the experimental titanium alloys titanium–5-zirconium, titanium–5-tantalum, and titanium–5-tantalum–5-zirconium (in wt%) with those of commercially pure titanium. Material and methods Specimens of titanium alloys and commercially pure titanium were cast by using plasma. Their modulus of elasticity and ultimate tensile strength were determined in a universal testing machine. Biocompatibility was evaluated with SCC9 cells. In periods of 1, 4, 7, 10, and 14 days, cell proliferation was evaluated by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay, and cell viability was evaluated in the 7-day period. Cell morphology was evaluated at 2, 12, and 24 hours. Modulus of elasticity, ultimate tensile strength, and cell viability were analyzed by 1-way ANOVA and the Bonferroni test; cell proliferation data were compared by 2-way ANOVA (alloy versus time) and by the Bonferroni test; and the cell morphology data were analyzed by split-plot design. All statistical tests were performed at the 95% confidence level ( P &lt;.05). Results Titanium–5-tantalum presented the lowest modulus of elasticity and ultimate tensile strength, whereas titanium–5-zirconium and titanium–5-tantalum–5-zirconium were statistically similar to commercially pure titanium. Cell proliferation and viability were not affected by any alloy being similar to those observed for commercially pure titanium. No noticeably differences were found in the morphology of cells cultured on any alloy and commercially pure titanium. Conclusion Experimental alloys, especially titanium–5-zirconium and titanium–5-tantalum–5-zirconium, presented promising mechanical results for future studies and clinical applications. In addition, these alloys, evaluated by cell proliferation, viability, and morphology, were found to be biocompatible in vitro.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25088209</pmid><doi>10.1016/j.prosdent.2013.12.025</doi><tpages>13</tpages></addata></record>
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source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Alloys - chemistry
Alloys - pharmacology
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Shape - drug effects
Cell Survival - drug effects
Dental Alloys - chemistry
Dental Alloys - pharmacology
Dental Casting Technique
Dental Materials - chemistry
Dental Materials - pharmacology
Dental Stress Analysis - instrumentation
Dentistry
Elastic Modulus
Humans
Materials Testing
Mechanical Phenomena
Microscopy, Electron, Scanning
Plasma Gases
Pliability
Tantalum - chemistry
Tantalum - pharmacology
Tensile Strength
Tetrazolium Salts
Thiazoles
Time Factors
Titanium - chemistry
Titanium - pharmacology
title Experimental titanium alloys for dental applications
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