Small dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liver
Serum small dense LDL-cholesterol (sdLDL-C) levels in healthy controls and the cases with diabetes (T2DM) and metabolic syndrome (MetS) with or without a fatty liver in a large, typical Japanese population was determined. The plasma lipids and lipoproteins, including sdLDL-C by homogeneous assay, we...
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| Veröffentlicht in: | Clinica chimica acta 2015-01, Vol.438, p.70-79 |
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| container_title | Clinica chimica acta |
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| creator | Kikkawa, Koji Nakajima, Katsuyuki Shimomura, Younosuke Tokita, Yoshiharu Machida, Tetsuo Sumino, Hiroyuki Murakami, Masami |
| description | Serum small dense LDL-cholesterol (sdLDL-C) levels in healthy controls and the cases with diabetes (T2DM) and metabolic syndrome (MetS) with or without a fatty liver in a large, typical Japanese population was determined.
The plasma lipids and lipoproteins, including sdLDL-C by homogeneous assay, were determined in controls, MetS and T2DM patients (n=5255). The cases with MetS and preliminary MetS (pre-MetS) as well as T2DM and preliminary T2DM (pre-DM) were selected based on the Japanese criteria for MetS and T2DM. Fatty liver was diagnosed using the ultrasonography.
The 75th percentile values for sdLDL-C were 27.5mg/dl for men and 23.3mg/dl for women and increased with age. The concentrations of sdLDL-C and sdLDL-C/LDL-C were significantly higher in pre-MetS and pre-T2DM patients than healthy controls as well as in MetS and T2DM patients. Significantly higher sdLDL-C was found in cases with a fatty liver than without a fatty liver in all five groups.
Significantly elevated sdLDL-C levels were found in pre-MetS, MetS and pre-T2DM, T2DM patients compared to the healthy controls. Fatty liver significantly enhanced serum sdLDL-C levels and the multiple regression analyses ascertained that fatty liver was an independent determinant for sdLDL-C.
•The normal range of sdLDL-C in Japanese population was determined.•sdLDL-C was significantly higher in pre-MetS and pre-T2DM than in controls.•sdLDL-C was highest in MetS and T2DM when associated with a fatty liver. |
| doi_str_mv | 10.1016/j.cca.2014.07.017 |
| format | Article |
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The plasma lipids and lipoproteins, including sdLDL-C by homogeneous assay, were determined in controls, MetS and T2DM patients (n=5255). The cases with MetS and preliminary MetS (pre-MetS) as well as T2DM and preliminary T2DM (pre-DM) were selected based on the Japanese criteria for MetS and T2DM. Fatty liver was diagnosed using the ultrasonography.
The 75th percentile values for sdLDL-C were 27.5mg/dl for men and 23.3mg/dl for women and increased with age. The concentrations of sdLDL-C and sdLDL-C/LDL-C were significantly higher in pre-MetS and pre-T2DM patients than healthy controls as well as in MetS and T2DM patients. Significantly higher sdLDL-C was found in cases with a fatty liver than without a fatty liver in all five groups.
Significantly elevated sdLDL-C levels were found in pre-MetS, MetS and pre-T2DM, T2DM patients compared to the healthy controls. Fatty liver significantly enhanced serum sdLDL-C levels and the multiple regression analyses ascertained that fatty liver was an independent determinant for sdLDL-C.
•The normal range of sdLDL-C in Japanese population was determined.•sdLDL-C was significantly higher in pre-MetS and pre-T2DM than in controls.•sdLDL-C was highest in MetS and T2DM when associated with a fatty liver.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2014.07.017</identifier><identifier>PMID: 25050800</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cholesterol, LDL - blood ; Coronary heart disease (CHD) ; Diabetes Complications - blood ; Fatty Liver ; Fatty Liver - blood ; Fatty Liver - complications ; Female ; Homogeneous sdLDL-C assay ; Humans ; Japan ; Male ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; MetS ; Middle Aged ; Preliminary-metabolic syndrome (pre-MetS) ; Preliminary-type 2 diabetes mellitus (pre-T2DM) ; T2DM</subject><ispartof>Clinica chimica acta, 2015-01, Vol.438, p.70-79</ispartof><rights>2014</rights><rights>Copyright © 2014. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-dbe9362cdb0b30618a2c0a6a0bbcbf2c6c3af4bab2f462f7451ad9cffcb42ce63</citedby><cites>FETCH-LOGICAL-c353t-dbe9362cdb0b30618a2c0a6a0bbcbf2c6c3af4bab2f462f7451ad9cffcb42ce63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009898114003040$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25050800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kikkawa, Koji</creatorcontrib><creatorcontrib>Nakajima, Katsuyuki</creatorcontrib><creatorcontrib>Shimomura, Younosuke</creatorcontrib><creatorcontrib>Tokita, Yoshiharu</creatorcontrib><creatorcontrib>Machida, Tetsuo</creatorcontrib><creatorcontrib>Sumino, Hiroyuki</creatorcontrib><creatorcontrib>Murakami, Masami</creatorcontrib><title>Small dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liver</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Serum small dense LDL-cholesterol (sdLDL-C) levels in healthy controls and the cases with diabetes (T2DM) and metabolic syndrome (MetS) with or without a fatty liver in a large, typical Japanese population was determined.
The plasma lipids and lipoproteins, including sdLDL-C by homogeneous assay, were determined in controls, MetS and T2DM patients (n=5255). The cases with MetS and preliminary MetS (pre-MetS) as well as T2DM and preliminary T2DM (pre-DM) were selected based on the Japanese criteria for MetS and T2DM. Fatty liver was diagnosed using the ultrasonography.
The 75th percentile values for sdLDL-C were 27.5mg/dl for men and 23.3mg/dl for women and increased with age. The concentrations of sdLDL-C and sdLDL-C/LDL-C were significantly higher in pre-MetS and pre-T2DM patients than healthy controls as well as in MetS and T2DM patients. Significantly higher sdLDL-C was found in cases with a fatty liver than without a fatty liver in all five groups.
Significantly elevated sdLDL-C levels were found in pre-MetS, MetS and pre-T2DM, T2DM patients compared to the healthy controls. Fatty liver significantly enhanced serum sdLDL-C levels and the multiple regression analyses ascertained that fatty liver was an independent determinant for sdLDL-C.
•The normal range of sdLDL-C in Japanese population was determined.•sdLDL-C was significantly higher in pre-MetS and pre-T2DM than in controls.•sdLDL-C was highest in MetS and T2DM when associated with a fatty liver.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Cholesterol, LDL - blood</subject><subject>Coronary heart disease (CHD)</subject><subject>Diabetes Complications - blood</subject><subject>Fatty Liver</subject><subject>Fatty Liver - blood</subject><subject>Fatty Liver - complications</subject><subject>Female</subject><subject>Homogeneous sdLDL-C assay</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>MetS</subject><subject>Middle Aged</subject><subject>Preliminary-metabolic syndrome (pre-MetS)</subject><subject>Preliminary-type 2 diabetes mellitus (pre-T2DM)</subject><subject>T2DM</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhAdggL1mQYDv_YoVafjVSF4W1dW3fEI-ceLCdVnkZnhW3U1h2dWXpfEc6_gh5zVnJGW_fH0qtoRSM1yXrSsa7J2TH-64qqnoQT8mOMTYU_dDzM_IixkN-1qzlz8mZaFjDesZ25M_1DM5Rg0tEur_cUz15hzFh8I7OCHENaKja6ORn_wsX9GukECNs1C70OxxhwUxOCC5NG9V-SZmM7zKbQHlnNY3bYoKfkcJiqLGgMGGkR0gWlxTprU0T9eH--jVRoCOktFFnbzC8JM9GcBFfPdxz8vPzpx8XX4v91ZdvFx_3ha6aKhVG4VC1QhvFVJUn9iA0gxaYUlqNQre6grFWoMRYt2Ls6oaDGfQ4alULjW11Tt6eeo_B_17zfjnbqNE5uF8seSuGoeVDw3OUn6I6-BgDjvIY7Axhk5zJOy3yILMWeadFsk5mLZl581C_qhnNf-Kfhxz4cApgHnljMcio8_doNDagTtJ4-0j9X8nAokc</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Kikkawa, Koji</creator><creator>Nakajima, Katsuyuki</creator><creator>Shimomura, Younosuke</creator><creator>Tokita, Yoshiharu</creator><creator>Machida, Tetsuo</creator><creator>Sumino, Hiroyuki</creator><creator>Murakami, Masami</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Small dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liver</title><author>Kikkawa, Koji ; Nakajima, Katsuyuki ; Shimomura, Younosuke ; Tokita, Yoshiharu ; Machida, Tetsuo ; Sumino, Hiroyuki ; Murakami, Masami</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-dbe9362cdb0b30618a2c0a6a0bbcbf2c6c3af4bab2f462f7451ad9cffcb42ce63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Cholesterol, LDL - blood</topic><topic>Coronary heart disease (CHD)</topic><topic>Diabetes Complications - blood</topic><topic>Fatty Liver</topic><topic>Fatty Liver - blood</topic><topic>Fatty Liver - complications</topic><topic>Female</topic><topic>Homogeneous sdLDL-C assay</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>MetS</topic><topic>Middle Aged</topic><topic>Preliminary-metabolic syndrome (pre-MetS)</topic><topic>Preliminary-type 2 diabetes mellitus (pre-T2DM)</topic><topic>T2DM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikkawa, Koji</creatorcontrib><creatorcontrib>Nakajima, Katsuyuki</creatorcontrib><creatorcontrib>Shimomura, Younosuke</creatorcontrib><creatorcontrib>Tokita, Yoshiharu</creatorcontrib><creatorcontrib>Machida, Tetsuo</creatorcontrib><creatorcontrib>Sumino, Hiroyuki</creatorcontrib><creatorcontrib>Murakami, Masami</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kikkawa, Koji</au><au>Nakajima, Katsuyuki</au><au>Shimomura, Younosuke</au><au>Tokita, Yoshiharu</au><au>Machida, Tetsuo</au><au>Sumino, Hiroyuki</au><au>Murakami, Masami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liver</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>438</volume><spage>70</spage><epage>79</epage><pages>70-79</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Serum small dense LDL-cholesterol (sdLDL-C) levels in healthy controls and the cases with diabetes (T2DM) and metabolic syndrome (MetS) with or without a fatty liver in a large, typical Japanese population was determined.
The plasma lipids and lipoproteins, including sdLDL-C by homogeneous assay, were determined in controls, MetS and T2DM patients (n=5255). The cases with MetS and preliminary MetS (pre-MetS) as well as T2DM and preliminary T2DM (pre-DM) were selected based on the Japanese criteria for MetS and T2DM. Fatty liver was diagnosed using the ultrasonography.
The 75th percentile values for sdLDL-C were 27.5mg/dl for men and 23.3mg/dl for women and increased with age. The concentrations of sdLDL-C and sdLDL-C/LDL-C were significantly higher in pre-MetS and pre-T2DM patients than healthy controls as well as in MetS and T2DM patients. Significantly higher sdLDL-C was found in cases with a fatty liver than without a fatty liver in all five groups.
Significantly elevated sdLDL-C levels were found in pre-MetS, MetS and pre-T2DM, T2DM patients compared to the healthy controls. Fatty liver significantly enhanced serum sdLDL-C levels and the multiple regression analyses ascertained that fatty liver was an independent determinant for sdLDL-C.
•The normal range of sdLDL-C in Japanese population was determined.•sdLDL-C was significantly higher in pre-MetS and pre-T2DM than in controls.•sdLDL-C was highest in MetS and T2DM when associated with a fatty liver.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25050800</pmid><doi>10.1016/j.cca.2014.07.017</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 2015-01, Vol.438, p.70-79 |
| issn | 0009-8981 1873-3492 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aged, 80 and over Case-Control Studies Cholesterol, LDL - blood Coronary heart disease (CHD) Diabetes Complications - blood Fatty Liver Fatty Liver - blood Fatty Liver - complications Female Homogeneous sdLDL-C assay Humans Japan Male Metabolic Syndrome - blood Metabolic Syndrome - complications MetS Middle Aged Preliminary-metabolic syndrome (pre-MetS) Preliminary-type 2 diabetes mellitus (pre-T2DM) T2DM |
| title | Small dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liver |
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