Phosphoneurofilament heavy chain and N-glycomics from the cerebrospinal fluid in amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron for which no clinically validated biomarkers have been identified. We have quantified by ELISA the biomarker phosphoneurofilament heavy chain (pNFH) in the cerebrospinal fluid (CSF) of ALS patients (n=29) an...

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Veröffentlicht in:	Clinica chimica acta 2015-01, Vol.438, p.342-349
Hauptverfasser:	Gonçalves, Margarida, Tillack, Linda, de Carvalho, Mamede, Pinto, Susana, Conradt, Harald S., Costa, Júlia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - chemistry Acetylglucosamine - isolation & purification Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - cerebrospinal fluid Amyotrophic Lateral Sclerosis - diagnosis Biomarker Biomarkers - cerebrospinal fluid Case-Control Studies Cerebrospinal fluid Chromatography, Liquid Disease Progression Enzyme-Linked Immunosorbent Assay Female Fucose - chemistry Fucose - isolation & purification Glycomics Glycomics - instrumentation Glycomics - methods Glycoproteins Glycosylation Humans Male Mass Spectrometry Middle Aged Neurofilament Proteins - cerebrospinal fluid Phosphoneurofilament heavy chain Phosphoproteins - cerebrospinal fluid Polysaccharides - chemistry Polysaccharides - isolation & purification Sialic Acids - chemistry Sialic Acids - isolation & purification
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