Acute hematopoietic stress in mice is followed by enhanced osteoclast maturation in the bone marrow microenvironment

Osteoclasts are components of hematopoietic stem cell (HSC) niches, but their role as contributors to the HSC homeostasis and release are still controversial. We aimed to investigate whether an acute blood loss of 10% of total blood content, along with the consequent intense hematopoiesis, would aff...

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Veröffentlicht in:	Experimental hematology 2014-11, Vol.42 (11), p.966-975
Hauptverfasser:	Kuzmac, Sania, Grcevic, Danka, Sucur, Alan, Ivcevic, Sanja, Katavic, Vedran
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, Ly - genetics Antigens, Ly - metabolism Biomarkers - metabolism Bone Marrow - metabolism Bone Morphogenetic Protein 6 - genetics Bone Morphogenetic Protein 6 - metabolism Cathepsin K - genetics Cathepsin K - metabolism Cell Differentiation Cell Proliferation Female Gene Expression Hematology, Oncology and Palliative Medicine Hematopoiesis - genetics Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Interleukins - genetics Interleukins - metabolism Lymphocytes - cytology Lymphocytes - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Osteoclasts - cytology Osteoclasts - metabolism Phlebotomy Primary Cell Culture Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Receptor Activator of Nuclear Factor-kappa B - genetics Receptor Activator of Nuclear Factor-kappa B - metabolism Spleen - cytology Spleen - metabolism Stress, Physiological
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