Immunohistochemical detection of ARID1A in colorectal carcinoma: loss of staining is associated with sporadic microsatellite unstable tumors with medullary histology and high TNM stage

Summary AT-rich interactive domain-containing protein 1A ( ARID1A ), a chromatin remodeling gene recently discovered to be a tumor suppressor in ovarian cancers, has been found to be mutated at low frequencies in many other tumors including colorectal carcinoma (CRC). An association between ARID1A a...

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Veröffentlicht in:	Human pathology 2014-12, Vol.45 (12), p.2430-2436
Hauptverfasser:	Ye, Jiqing, MD, Zhou, Yi, MD, Weiser, Martin R., MD, Gönen, Mithat, PhD, Zhang, Liying, MD, Samdani, Tushar, MD, Bacares, Ruben, BS, DeLair, Deborah, MD, Ivelja, Sinisa, MD, Vakiani, Efsevia, MD, PhD, Klimstra, David S., MD, Soslow, Robert A., MD, Shia, Jinru, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adolescent Adult Aged Aged, 80 and over Carcinoma, Medullary - genetics Carcinoma, Medullary - metabolism Carcinoma, Medullary - pathology Cloning Colon cancer Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology DNA Methylation DNA Mismatch Repair Female Histology Humans Immunohistochemistry Lymphocytes Male Microsatellite Instability Middle Aged MLH1 and PMS2 MLH1 methylation Mutation MutL Protein Homolog 1 Neoplasm Staging Nuclear Proteins - genetics Nuclear Proteins - metabolism Pathology Patients Pilot Projects Polyclonal antibodies Promoter Regions, Genetic Proteins Transcription Factors - metabolism Tumors Young Adult
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