The biology of Lubricin: Near frictionless joint motion
Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion. Arthropathy occurring in p...
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| Veröffentlicht in: | Matrix biology 2014-10, Vol.39, p.17-24 |
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| creator | Jay, Gregory D. Waller, Kimberly A. |
| description | Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion. Arthropathy occurring in patients with joint trauma, inflammatory arthritis or genetically mediated lubricin deficiencies have insufficient lubricin to prevent damage to articular cartilage. Recent studies in lubricin null joints indicate that lubricin (Prg4) plays a role in preventing damage to the superficial zone and preservation of chondrocytes. Progress in the production of recombinant forms of lubricin and the successes of lubricin supplementation in small animal models identify rhPRG4 as a potential therapeutic for patients with transient lubricin deficiency in the setting of trauma or autoimmune arthritis. |
| doi_str_mv | 10.1016/j.matbio.2014.08.008 |
| format | Article |
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In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion. Arthropathy occurring in patients with joint trauma, inflammatory arthritis or genetically mediated lubricin deficiencies have insufficient lubricin to prevent damage to articular cartilage. Recent studies in lubricin null joints indicate that lubricin (Prg4) plays a role in preventing damage to the superficial zone and preservation of chondrocytes. Progress in the production of recombinant forms of lubricin and the successes of lubricin supplementation in small animal models identify rhPRG4 as a potential therapeutic for patients with transient lubricin deficiency in the setting of trauma or autoimmune arthritis.</description><identifier>ISSN: 0945-053X</identifier><identifier>EISSN: 1569-1802</identifier><identifier>DOI: 10.1016/j.matbio.2014.08.008</identifier><identifier>PMID: 25172828</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Biomechanical Phenomena ; Cartilage, Articular - metabolism ; Cartilage, Articular - pathology ; Chondrocytes ; Chondrocytes - metabolism ; Glycoproteins - physiology ; Humans ; Lubricin ; Mouse ; Osteoarthritis ; Osteoarthritis - metabolism ; Osteoarthritis - pathology ; Tribology</subject><ispartof>Matrix biology, 2014-10, Vol.39, p.17-24</ispartof><rights>2014</rights><rights>Copyright © 2014. 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Progress in the production of recombinant forms of lubricin and the successes of lubricin supplementation in small animal models identify rhPRG4 as a potential therapeutic for patients with transient lubricin deficiency in the setting of trauma or autoimmune arthritis.</description><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Cartilage, Articular - metabolism</subject><subject>Cartilage, Articular - pathology</subject><subject>Chondrocytes</subject><subject>Chondrocytes - metabolism</subject><subject>Glycoproteins - physiology</subject><subject>Humans</subject><subject>Lubricin</subject><subject>Mouse</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - metabolism</subject><subject>Osteoarthritis - pathology</subject><subject>Tribology</subject><issn>0945-053X</issn><issn>1569-1802</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo7rr6DUR69NI6SdM29SDI4j9Y9LKCt5CmE83SNpq0wn57u3T16GmYmffmMT9CzikkFGh-tUla1VfWJQwoT0AkAOKAzGmWlzEVwA7JHEqexZClbzNyEsIGADgvxDGZsYwWTDAxJ8X6A6PxSuPet5Ez0WqovNW2u46eUfnIjE1vXddgCNHG2a6PWrcbnJIjo5qAZ_u6IK_3d-vlY7x6eXha3q5izQvex0ogGA6FpsroOq90lvISFcsrNi6gwBpSrgRklKWq5FWtNBpWGTCZoqlW6YJcTnc_vfsaMPSytUFj06gO3RAkzVlZZqLg6Sjlk1R7F4JHIz-9bZXfSgpyh0xu5IRM7pBJEHJENtou9glD1WL9Z_plNApuJgGOf35b9DJoi53G2nrUvayd_T_hB0nBfxA</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Jay, Gregory D.</creator><creator>Waller, Kimberly A.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>The biology of Lubricin: Near frictionless joint motion</title><author>Jay, Gregory D. ; Waller, Kimberly A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-a8e0f407c1afcd6bc5349ea26b2e0f07ed034a805123a94bdacef2bf0f5a13ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>Cartilage, Articular - metabolism</topic><topic>Cartilage, Articular - pathology</topic><topic>Chondrocytes</topic><topic>Chondrocytes - metabolism</topic><topic>Glycoproteins - physiology</topic><topic>Humans</topic><topic>Lubricin</topic><topic>Mouse</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - metabolism</topic><topic>Osteoarthritis - pathology</topic><topic>Tribology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jay, Gregory D.</creatorcontrib><creatorcontrib>Waller, Kimberly A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Matrix biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jay, Gregory D.</au><au>Waller, Kimberly A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The biology of Lubricin: Near frictionless joint motion</atitle><jtitle>Matrix biology</jtitle><addtitle>Matrix Biol</addtitle><date>2014-10</date><risdate>2014</risdate><volume>39</volume><spage>17</spage><epage>24</epage><pages>17-24</pages><issn>0945-053X</issn><eissn>1569-1802</eissn><abstract>Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. 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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biomechanical Phenomena Cartilage, Articular - metabolism Cartilage, Articular - pathology Chondrocytes Chondrocytes - metabolism Glycoproteins - physiology Humans Lubricin Mouse Osteoarthritis Osteoarthritis - metabolism Osteoarthritis - pathology Tribology |
| title | The biology of Lubricin: Near frictionless joint motion |
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