Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years
Purpose To study longitudinal changes in the posterior pole in eyes with dome-shaped macular configuration within the staphyloma. Design Prospective, longitudinal study. Methods We prospectively examined the macular area in 35 eyes (26 patients) with dome-shaped macular configuration and high myopia...
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| Veröffentlicht in: | American journal of ophthalmology 2014-11, Vol.158 (5), p.1062-1070.e2 |
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| creator | Ellabban, Abdallah A Tsujikawa, Akitaka Muraoka, Yuki Yamashiro, Kenji Oishi, Akio Ooto, Sotaro Nakanishi, Hideo Kuroda, Yoshimasa Hata, Masayuki Takahashi, Ayako Yoshimura, Nagahisa |
| description | Purpose To study longitudinal changes in the posterior pole in eyes with dome-shaped macular configuration within the staphyloma. Design Prospective, longitudinal study. Methods We prospectively examined the macular area in 35 eyes (26 patients) with dome-shaped macular configuration and high myopia (mean spherical equivalent, −14.83 ± 4.50 diopters) using swept-source optical coherence tomography. Scleral and choroidal thicknesses were measured at the fovea and at 4 parafoveal locations 2000 μm from the foveal center. Height of the macular bulge was measured as well. Results During the mean follow-up of 24.8 ± 2.5 months, the scleral thickness significantly decreased at the fovea from 496.1 ± 95.7 μm to 484.7 ± 96.2 μm ( P < .001) and at all 4 parafoveal locations ( P < .001, respectively). The scleral thinning was asymmetric, with an estimated decrease per year of 5.6 μm at the foveal center, 11.1 μm superiorly, 12.1 μm inferiorly, 10.4 μm temporally, and 5.8 μm nasally. The ocular concavities deepened over time, and mean macular bulge height increased from 136.5 ± 60.9 μm to 157.6 ± 67.0 μm ( P < .001). The choroid within the staphyloma showed generalized thinning during follow-up. Mean choroidal thickness decreased significantly at the fovea from 28.3 ± 17.2 μm at baseline to 22.9 ± 17.2 μm ( P < .001). Conclusions Progressive asymmetric scleral thinning occurred in the macular region of eyes with dome-shaped macular configuration. The scleral thinning was more pronounced in the parafoveal area than at the foveal center, resulting in an increase of the macular bulge height. |
| doi_str_mv | 10.1016/j.ajo.2014.08.006 |
| format | Article |
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Design Prospective, longitudinal study. Methods We prospectively examined the macular area in 35 eyes (26 patients) with dome-shaped macular configuration and high myopia (mean spherical equivalent, −14.83 ± 4.50 diopters) using swept-source optical coherence tomography. Scleral and choroidal thicknesses were measured at the fovea and at 4 parafoveal locations 2000 μm from the foveal center. Height of the macular bulge was measured as well. Results During the mean follow-up of 24.8 ± 2.5 months, the scleral thickness significantly decreased at the fovea from 496.1 ± 95.7 μm to 484.7 ± 96.2 μm ( P < .001) and at all 4 parafoveal locations ( P < .001, respectively). The scleral thinning was asymmetric, with an estimated decrease per year of 5.6 μm at the foveal center, 11.1 μm superiorly, 12.1 μm inferiorly, 10.4 μm temporally, and 5.8 μm nasally. The ocular concavities deepened over time, and mean macular bulge height increased from 136.5 ± 60.9 μm to 157.6 ± 67.0 μm ( P < .001). The choroid within the staphyloma showed generalized thinning during follow-up. Mean choroidal thickness decreased significantly at the fovea from 28.3 ± 17.2 μm at baseline to 22.9 ± 17.2 μm ( P < .001). Conclusions Progressive asymmetric scleral thinning occurred in the macular region of eyes with dome-shaped macular configuration. The scleral thinning was more pronounced in the parafoveal area than at the foveal center, resulting in an increase of the macular bulge height.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2014.08.006</identifier><identifier>PMID: 25124265</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Axial Length, Eye - pathology ; Cataracts ; Choroid - pathology ; Dilatation, Pathologic ; Disease Progression ; Eye surgery ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Fundus Oculi ; Humans ; Imaging, Three-Dimensional ; Macula Lutea - pathology ; Macular degeneration ; Male ; Medical imaging ; Middle Aged ; Myopia, Degenerative - diagnosis ; Ophthalmology ; Prospective Studies ; Retinal Pigment Epithelium - pathology ; Sclera - pathology ; Surgery ; Time Factors ; Tomography, Optical Coherence - methods ; Visual Acuity - physiology</subject><ispartof>American journal of ophthalmology, 2014-11, Vol.158 (5), p.1062-1070.e2</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-582d5977a6245495395cf927ccf212e7a7bbe260bff8ce528eccadd5275f51f43</citedby><cites>FETCH-LOGICAL-c572t-582d5977a6245495395cf927ccf212e7a7bbe260bff8ce528eccadd5275f51f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2014.08.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25124265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellabban, Abdallah A</creatorcontrib><creatorcontrib>Tsujikawa, Akitaka</creatorcontrib><creatorcontrib>Muraoka, Yuki</creatorcontrib><creatorcontrib>Yamashiro, Kenji</creatorcontrib><creatorcontrib>Oishi, Akio</creatorcontrib><creatorcontrib>Ooto, Sotaro</creatorcontrib><creatorcontrib>Nakanishi, Hideo</creatorcontrib><creatorcontrib>Kuroda, Yoshimasa</creatorcontrib><creatorcontrib>Hata, Masayuki</creatorcontrib><creatorcontrib>Takahashi, Ayako</creatorcontrib><creatorcontrib>Yoshimura, Nagahisa</creatorcontrib><title>Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Purpose To study longitudinal changes in the posterior pole in eyes with dome-shaped macular configuration within the staphyloma. Design Prospective, longitudinal study. Methods We prospectively examined the macular area in 35 eyes (26 patients) with dome-shaped macular configuration and high myopia (mean spherical equivalent, −14.83 ± 4.50 diopters) using swept-source optical coherence tomography. Scleral and choroidal thicknesses were measured at the fovea and at 4 parafoveal locations 2000 μm from the foveal center. Height of the macular bulge was measured as well. Results During the mean follow-up of 24.8 ± 2.5 months, the scleral thickness significantly decreased at the fovea from 496.1 ± 95.7 μm to 484.7 ± 96.2 μm ( P < .001) and at all 4 parafoveal locations ( P < .001, respectively). The scleral thinning was asymmetric, with an estimated decrease per year of 5.6 μm at the foveal center, 11.1 μm superiorly, 12.1 μm inferiorly, 10.4 μm temporally, and 5.8 μm nasally. The ocular concavities deepened over time, and mean macular bulge height increased from 136.5 ± 60.9 μm to 157.6 ± 67.0 μm ( P < .001). The choroid within the staphyloma showed generalized thinning during follow-up. Mean choroidal thickness decreased significantly at the fovea from 28.3 ± 17.2 μm at baseline to 22.9 ± 17.2 μm ( P < .001). Conclusions Progressive asymmetric scleral thinning occurred in the macular region of eyes with dome-shaped macular configuration. The scleral thinning was more pronounced in the parafoveal area than at the foveal center, resulting in an increase of the macular bulge height.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Axial Length, Eye - pathology</subject><subject>Cataracts</subject><subject>Choroid - pathology</subject><subject>Dilatation, Pathologic</subject><subject>Disease Progression</subject><subject>Eye surgery</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Follow-Up Studies</subject><subject>Fundus Oculi</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Macula Lutea - pathology</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Myopia, Degenerative - diagnosis</subject><subject>Ophthalmology</subject><subject>Prospective Studies</subject><subject>Retinal Pigment Epithelium - pathology</subject><subject>Sclera - pathology</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Visual Acuity - physiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk-L1DAYxoso7uzqB_AiAS9eWpO0aVoFQcb1D4zMoePBU0iTt9PUtukm7S7zIfzOpsyqsAdPIcnveeB9njeKXhCcEEzyN10iO5tQTLIEFwnG-aNoQwpexqQoyeNogzGmcZmW2UV06X0XrjnP-NPogjJCM5qzTfTrox0grlo5gUbfpFp66dDWjo05Lk7Oxo5v0c6ORzMv2oyyR9tWjkfwyIxobgFVqgcnkRx1-LHOGo3qE6ruYJrjyi5OAdpPs1Gr0rbgYAwvBzvYo5NTe0L7W3DocGfRD5DOP4ueNLL38Pz-vIq-f7o-bL_Eu_3nr9sPu1gxTueYFVSzknOZ04xlJUtLppqScqUaSihwyesaaI7rpikUMFqAUlJrRjlrGGmy9Cp6ffadnL1ZwM9iMF5B38sR7OIFyWkZbCnBAX31AO3CWCGJlSJZSDFlaaDImVLOeu-gEZMzg3QnQbBYuxKdCF2JtSuBCxGaCJqX985LPYD-q_hTTgDenQEIUdwacMIrswaojQM1C23Nf-3fP1Cr3oxrEz_hBP7fFMJTgUW1Lsu6KyTDOCvyNP0NLou5sg</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Ellabban, Abdallah A</creator><creator>Tsujikawa, Akitaka</creator><creator>Muraoka, Yuki</creator><creator>Yamashiro, Kenji</creator><creator>Oishi, Akio</creator><creator>Ooto, Sotaro</creator><creator>Nakanishi, Hideo</creator><creator>Kuroda, Yoshimasa</creator><creator>Hata, Masayuki</creator><creator>Takahashi, Ayako</creator><creator>Yoshimura, Nagahisa</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years</title><author>Ellabban, Abdallah A ; Tsujikawa, Akitaka ; Muraoka, Yuki ; Yamashiro, Kenji ; Oishi, Akio ; Ooto, Sotaro ; Nakanishi, Hideo ; Kuroda, Yoshimasa ; Hata, Masayuki ; Takahashi, Ayako ; Yoshimura, Nagahisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-582d5977a6245495395cf927ccf212e7a7bbe260bff8ce528eccadd5275f51f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Axial Length, Eye - pathology</topic><topic>Cataracts</topic><topic>Choroid - pathology</topic><topic>Dilatation, Pathologic</topic><topic>Disease Progression</topic><topic>Eye surgery</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Follow-Up Studies</topic><topic>Fundus Oculi</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Macula Lutea - pathology</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Myopia, Degenerative - diagnosis</topic><topic>Ophthalmology</topic><topic>Prospective Studies</topic><topic>Retinal Pigment Epithelium - pathology</topic><topic>Sclera - pathology</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellabban, Abdallah A</creatorcontrib><creatorcontrib>Tsujikawa, Akitaka</creatorcontrib><creatorcontrib>Muraoka, Yuki</creatorcontrib><creatorcontrib>Yamashiro, Kenji</creatorcontrib><creatorcontrib>Oishi, Akio</creatorcontrib><creatorcontrib>Ooto, Sotaro</creatorcontrib><creatorcontrib>Nakanishi, Hideo</creatorcontrib><creatorcontrib>Kuroda, Yoshimasa</creatorcontrib><creatorcontrib>Hata, Masayuki</creatorcontrib><creatorcontrib>Takahashi, Ayako</creatorcontrib><creatorcontrib>Yoshimura, Nagahisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellabban, Abdallah A</au><au>Tsujikawa, Akitaka</au><au>Muraoka, Yuki</au><au>Yamashiro, Kenji</au><au>Oishi, Akio</au><au>Ooto, Sotaro</au><au>Nakanishi, Hideo</au><au>Kuroda, Yoshimasa</au><au>Hata, Masayuki</au><au>Takahashi, Ayako</au><au>Yoshimura, Nagahisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>158</volume><issue>5</issue><spage>1062</spage><epage>1070.e2</epage><pages>1062-1070.e2</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Purpose To study longitudinal changes in the posterior pole in eyes with dome-shaped macular configuration within the staphyloma. Design Prospective, longitudinal study. Methods We prospectively examined the macular area in 35 eyes (26 patients) with dome-shaped macular configuration and high myopia (mean spherical equivalent, −14.83 ± 4.50 diopters) using swept-source optical coherence tomography. Scleral and choroidal thicknesses were measured at the fovea and at 4 parafoveal locations 2000 μm from the foveal center. Height of the macular bulge was measured as well. Results During the mean follow-up of 24.8 ± 2.5 months, the scleral thickness significantly decreased at the fovea from 496.1 ± 95.7 μm to 484.7 ± 96.2 μm ( P < .001) and at all 4 parafoveal locations ( P < .001, respectively). The scleral thinning was asymmetric, with an estimated decrease per year of 5.6 μm at the foveal center, 11.1 μm superiorly, 12.1 μm inferiorly, 10.4 μm temporally, and 5.8 μm nasally. The ocular concavities deepened over time, and mean macular bulge height increased from 136.5 ± 60.9 μm to 157.6 ± 67.0 μm ( P < .001). The choroid within the staphyloma showed generalized thinning during follow-up. Mean choroidal thickness decreased significantly at the fovea from 28.3 ± 17.2 μm at baseline to 22.9 ± 17.2 μm ( P < .001). Conclusions Progressive asymmetric scleral thinning occurred in the macular region of eyes with dome-shaped macular configuration. The scleral thinning was more pronounced in the parafoveal area than at the foveal center, resulting in an increase of the macular bulge height.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25124265</pmid><doi>10.1016/j.ajo.2014.08.006</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Axial Length, Eye - pathology Cataracts Choroid - pathology Dilatation, Pathologic Disease Progression Eye surgery Female Fluorescein Angiography Follow-Up Studies Fundus Oculi Humans Imaging, Three-Dimensional Macula Lutea - pathology Macular degeneration Male Medical imaging Middle Aged Myopia, Degenerative - diagnosis Ophthalmology Prospective Studies Retinal Pigment Epithelium - pathology Sclera - pathology Surgery Time Factors Tomography, Optical Coherence - methods Visual Acuity - physiology |
| title | Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years |
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