Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents

We have previously shown that 3-nitro-1H-1,2,4-triazole-based arylamides and arylsulfonamides demonstrate significant activity in vitro against Trypanosoma cruzi, the causative parasite of Chagas disease. More importantly, several such analogs displayed significant antichagasic activity in vivo, sup...

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Veröffentlicht in:	European journal of medicinal chemistry 2014-11, Vol.87, p.79-88
Hauptverfasser:	Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Kaiser, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacology Antitrypanosomal agents Apoptosis - drug effects Blood Platelets - drug effects Blood Platelets - parasitology Cells, Cultured Chagas disease Chagas Disease - drug therapy Chagas Disease - parasitology Flow Cytometry Heteroarylamides Heteroarylsulfonamides Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Humans Imidazoles - chemistry In Vitro Techniques Leishmania donovani - drug effects Leishmaniasis, Visceral - drug therapy Leishmaniasis, Visceral - parasitology Molecular Structure Monocytes - drug effects Monocytes - parasitology Nitroimidazoles Nitrotriazoles Platelet Activation - drug effects Sulfonamides - chemistry Sulfonamides - pharmacology Triazoles - chemistry Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma cruzi - drug effects
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