Purification of nuclear proteins that bind to cisplatin-damaged DNA. Identity with high mobility group proteins 1 and 2

The biochemical processes responsible for the recognition and repair of cisplatin-damaged DNA in human cells are not well understood. We have developed a damaged DNA affinity precipitation technique that allows the direct visualization and characterization of cellular proteins that bind to cisplatin...

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Veröffentlicht in:	The Journal of biological chemistry 1992-07, Vol.267 (19), p.13520-13527
Hauptverfasser:	HUGHES, E. N, ENGELSBERG, B. N, BILLINGS, P. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, Affinity Chromatography, Ion Exchange Cisplatin - toxicity DNA - metabolism DNA Damage DNA Repair Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology HeLa Cells High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Holoproteins Humans Molecular Sequence Data Nuclear proteins Nuclear Proteins - isolation & purification Nuclear Proteins - metabolism Proteins Substrate Specificity
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