Efficient exploration of chemical space by fragment-based screening

Screening methods seek to sample a vast chemical space in order to identify starting points for further chemical optimisation. Fragment based drug discovery exploits the superior sampling of chemical space that can be achieved when the molecular weight is restricted. Here we show that commercially a...

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Veröffentlicht in:	Progress in biophysics and molecular biology 2014-11, Vol.116 (2-3), p.82-91
Hauptverfasser:	Hall, Richard J., Mortenson, Paul N., Murray, Christopher W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3D fragments Drug Evaluation, Preclinical - methods Fragment library Fragment-based drug design Pharmaceutical Preparations - chemistry Properties of fragment hits Size of chemical space Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology
Online-Zugang:	Volltext
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