A rapid and sensitive UPLC–MS/MS method for determination of HZ08 in rat plasma and tissues: Application to a pharmacokinetic study of liposome injections

•A UPLC–MS/MS method was developed to determine HZ08 in rat plasma and tissues.•The total analysis time was 4.0min.•The method was applied to pharmacokinetic study of HZ08 in rats.•HZ08 had linear pharmacokinetic properties with a rapid elimination phase.•The major distribution tissues of HZ08 in ra...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2015-01, Vol.102, p.246-252
Hauptverfasser:	Yan, Fang, Sun, Miaomiao, Hang, Taijun, Sun, Jing, Zhou, Xia, Deng, Xin, Ge, Liang, Qian, Hai, Ya, Ding, Huang, Wenlong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calibration Chromatography, High Pressure Liquid - methods HZ08 Injections Isoquinolines - administration & dosage Isoquinolines - pharmacokinetics Liposomes Pharmacokinetics Rat plasma Rat tissues Rats Rats, Sprague-Dawley Tandem Mass Spectrometry - methods Tissue Distribution UPLC–MS/MS
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