A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response
Abstract Social isolation is common in the elderly exerting negative effects on neuroimmunoendocrine communication. Nevertheless physiological responses to a stressful situation may vary according to diverse factors. This work studies the differences in the immune response of aged male rats socially...
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| Veröffentlicht in: | Journal of neuroimmunology 2014-12, Vol.277 (1), p.18-25 |
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| container_title | Journal of neuroimmunology |
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| creator | Cruces, Julia Venero, César Pereda-Pérez, Inmaculada De la Fuente, Mónica |
| description | Abstract Social isolation is common in the elderly exerting negative effects on neuroimmunoendocrine communication. Nevertheless physiological responses to a stressful situation may vary according to diverse factors. This work studies the differences in the immune response of aged male rats socially isolated depending on the anxiety levels produced. Social isolation impaired certain immunological parameters, but a more anxious response to isolation was associated to global severe immunosuppression and greater oxidative state. Thus, responding anxiously to isolation may suppose a more potent risk of morbidity and mortality further than isolation and anxiety by themselves, particularly in elderly subjects. |
| doi_str_mv | 10.1016/j.jneuroim.2014.09.011 |
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Nevertheless physiological responses to a stressful situation may vary according to diverse factors. This work studies the differences in the immune response of aged male rats socially isolated depending on the anxiety levels produced. Social isolation impaired certain immunological parameters, but a more anxious response to isolation was associated to global severe immunosuppression and greater oxidative state. Thus, responding anxiously to isolation may suppose a more potent risk of morbidity and mortality further than isolation and anxiety by themselves, particularly in elderly subjects.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2014.09.011</identifier><identifier>PMID: 25266143</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aging ; Allergy and Immunology ; Animals ; Anxiety ; Anxiety - complications ; Anxiety - etiology ; Body Weight - drug effects ; Cell Proliferation - drug effects ; Chemotaxis - immunology ; Cytokines - metabolism ; Disease Models, Animal ; Glutathione - metabolism ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; Immune response ; Immune System Diseases - etiology ; Immune System Diseases - pathology ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - metabolism ; Leukocytes - drug effects ; Leukocytes - pathology ; Male ; Males ; Maze Learning - physiology ; Neurology ; Oxidative Stress - immunology ; Rats ; Rats, Wistar ; Social Isolation ; Xanthine Oxidase - metabolism</subject><ispartof>Journal of neuroimmunology, 2014-12, Vol.277 (1), p.18-25</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-5604baff62fb8d360155141ba50c3873f512da2f2ff2385533a17090c2ccaa553</citedby><cites>FETCH-LOGICAL-c476t-5604baff62fb8d360155141ba50c3873f512da2f2ff2385533a17090c2ccaa553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572814008881$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25266143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruces, Julia</creatorcontrib><creatorcontrib>Venero, César</creatorcontrib><creatorcontrib>Pereda-Pérez, Inmaculada</creatorcontrib><creatorcontrib>De la Fuente, Mónica</creatorcontrib><title>A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Social isolation is common in the elderly exerting negative effects on neuroimmunoendocrine communication. Nevertheless physiological responses to a stressful situation may vary according to diverse factors. This work studies the differences in the immune response of aged male rats socially isolated depending on the anxiety levels produced. Social isolation impaired certain immunological parameters, but a more anxious response to isolation was associated to global severe immunosuppression and greater oxidative state. Thus, responding anxiously to isolation may suppose a more potent risk of morbidity and mortality further than isolation and anxiety by themselves, particularly in elderly subjects.</description><subject>Aging</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - complications</subject><subject>Anxiety - etiology</subject><subject>Body Weight - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemotaxis - immunology</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - metabolism</subject><subject>Immune response</subject><subject>Immune System Diseases - etiology</subject><subject>Immune System Diseases - pathology</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - pathology</subject><subject>Male</subject><subject>Males</subject><subject>Maze Learning - physiology</subject><subject>Neurology</subject><subject>Oxidative Stress - immunology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Social Isolation</subject><subject>Xanthine Oxidase - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v3CAQhlHVqtkm_QsRx17sMGD8cakaRf2SIvXQ5IxYPHRxbdgCrrL_vmw26aGXnoDhnXdmniHkElgNDNqrqZ48rjG4peYMmpoNNQN4QTbQd7zqGw4vyaYIZSU73p-RNylNjIEUzfCanHHJ2xYasSHhmu7cjx1Gqv2Dw3ygKeuM1Hka5pFGnRPVNpf_FIzTM3UpzDq74MuN6vQYzTjSHIoDdcteu7igzzRYmnfFaFlWjzRi2gef8IK8snpO-PbpPCf3nz7e3Xypbr99_npzfVuZpmtzJVvWbLW1LbfbfhRt6VxCA1stmRF9J6wEPmpuubVc9FIKoaFjAzPcGK3L-5y8O_nuY_i1YspqccngPGuPYU0KWj7IgkqwIm1PUhNDShGt2ke36HhQwNQRtprUM2x1hK3YoArsknj5VGPdLjj-TXumWwQfTgIsk_52GFUyDr3B0UU0WY3B_b_G-38szOy8M3r-iQdMU1ijLxwVqMQVU9-PKz9uHBrG-r4H8QcbHamK</recordid><startdate>20141215</startdate><enddate>20141215</enddate><creator>Cruces, Julia</creator><creator>Venero, César</creator><creator>Pereda-Pérez, Inmaculada</creator><creator>De la Fuente, Mónica</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141215</creationdate><title>A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response</title><author>Cruces, Julia ; Venero, César ; Pereda-Pérez, Inmaculada ; De la Fuente, Mónica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-5604baff62fb8d360155141ba50c3873f512da2f2ff2385533a17090c2ccaa553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aging</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - complications</topic><topic>Anxiety - etiology</topic><topic>Body Weight - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Chemotaxis - immunology</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - metabolism</topic><topic>Immune response</topic><topic>Immune System Diseases - etiology</topic><topic>Immune System Diseases - pathology</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - pathology</topic><topic>Male</topic><topic>Males</topic><topic>Maze Learning - physiology</topic><topic>Neurology</topic><topic>Oxidative Stress - immunology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Social Isolation</topic><topic>Xanthine Oxidase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruces, Julia</creatorcontrib><creatorcontrib>Venero, César</creatorcontrib><creatorcontrib>Pereda-Pérez, Inmaculada</creatorcontrib><creatorcontrib>De la Fuente, Mónica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruces, Julia</au><au>Venero, César</au><au>Pereda-Pérez, Inmaculada</au><au>De la Fuente, Mónica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2014-12-15</date><risdate>2014</risdate><volume>277</volume><issue>1</issue><spage>18</spage><epage>25</epage><pages>18-25</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Social isolation is common in the elderly exerting negative effects on neuroimmunoendocrine communication. Nevertheless physiological responses to a stressful situation may vary according to diverse factors. This work studies the differences in the immune response of aged male rats socially isolated depending on the anxiety levels produced. Social isolation impaired certain immunological parameters, but a more anxious response to isolation was associated to global severe immunosuppression and greater oxidative state. Thus, responding anxiously to isolation may suppose a more potent risk of morbidity and mortality further than isolation and anxiety by themselves, particularly in elderly subjects.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25266143</pmid><doi>10.1016/j.jneuroim.2014.09.011</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 2014-12, Vol.277 (1), p.18-25 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aging Allergy and Immunology Animals Anxiety Anxiety - complications Anxiety - etiology Body Weight - drug effects Cell Proliferation - drug effects Chemotaxis - immunology Cytokines - metabolism Disease Models, Animal Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Immune response Immune System Diseases - etiology Immune System Diseases - pathology Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Leukocytes - drug effects Leukocytes - pathology Male Males Maze Learning - physiology Neurology Oxidative Stress - immunology Rats Rats, Wistar Social Isolation Xanthine Oxidase - metabolism |
| title | A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response |
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