Study on the extraction process of total anthraquinones in Radix et Rhizoma Rhei and their antilipemic effects
Radix et Rhizoma Rhei has a gastric mucosal protective effect, major anti-gastritis and anti-peptic ulcer active constituents were emodin, aloe-emodin, chrysophanol, rhein, etc. The objective of the study was the extraction process of total anthraquinones in Radix et Rhizoma rhei and their antilipem...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014, Vol.11 (2), p.358-362 |
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| container_title | African journal of traditional, complementary, and alternative medicines |
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| creator | Xie, Hui-Chun Shang, Jun |
| description | Radix et Rhizoma Rhei has a gastric mucosal protective effect, major anti-gastritis and anti-peptic ulcer active constituents were emodin, aloe-emodin, chrysophanol, rhein, etc. The objective of the study was the extraction process of total anthraquinones in Radix et Rhizoma rhei and their antilipemic effects.
Orthogonal experiment, UV spectrophotometry and conventional antilipemic effect determination method were used to optimize the extraction process, and to determine the total anthraquinone content, as well as blood levels of total cholesterol, triglycerides, HDL and LDL.
Ethanol concentration, extraction time and ethanol amount had significant influences on the extraction of total Radix et Rhizoma rhei anthraquinones, total Radix et Rhizoma rhei anthraquinones could significantly reduce blood levels of total cholesterol, triglycerides, HDL and LDL.
The optimum extraction process was two times extraction of Radix et Rhizoma rhei with 70% ethanol, the amounts of solvent of 8 folds and 5 folds, successively, and the extraction time of 60 min each. In addition, this extract has an antilipemic effect in mice. |
| doi_str_mv | 10.4314/ajtcam.v11i2.22 |
| format | Article |
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Orthogonal experiment, UV spectrophotometry and conventional antilipemic effect determination method were used to optimize the extraction process, and to determine the total anthraquinone content, as well as blood levels of total cholesterol, triglycerides, HDL and LDL.
Ethanol concentration, extraction time and ethanol amount had significant influences on the extraction of total Radix et Rhizoma rhei anthraquinones, total Radix et Rhizoma rhei anthraquinones could significantly reduce blood levels of total cholesterol, triglycerides, HDL and LDL.
The optimum extraction process was two times extraction of Radix et Rhizoma rhei with 70% ethanol, the amounts of solvent of 8 folds and 5 folds, successively, and the extraction time of 60 min each. In addition, this extract has an antilipemic effect in mice.</description><identifier>EISSN: 2505-0044</identifier><identifier>DOI: 10.4314/ajtcam.v11i2.22</identifier><identifier>PMID: 25435622</identifier><language>eng</language><publisher>Nigeria</publisher><subject><![CDATA[Animals ; Anthraquinones - administration & dosage ; Anthraquinones - analysis ; Anthraquinones - isolation & purification ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - analysis ; Drugs, Chinese Herbal - isolation & purification ; Female ; Humans ; Hyperlipidemias - drug therapy ; Hyperlipidemias - metabolism ; Hypolipidemic Agents - administration & dosage ; Hypolipidemic Agents - analysis ; Hypolipidemic Agents - isolation & purification ; Male ; Mice ; Rheum - chemistry ; Rhizome - chemistry]]></subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2014, Vol.11 (2), p.358-362</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25435622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Hui-Chun</creatorcontrib><creatorcontrib>Shang, Jun</creatorcontrib><title>Study on the extraction process of total anthraquinones in Radix et Rhizoma Rhei and their antilipemic effects</title><title>African journal of traditional, complementary, and alternative medicines</title><addtitle>Afr J Tradit Complement Altern Med</addtitle><description>Radix et Rhizoma Rhei has a gastric mucosal protective effect, major anti-gastritis and anti-peptic ulcer active constituents were emodin, aloe-emodin, chrysophanol, rhein, etc. The objective of the study was the extraction process of total anthraquinones in Radix et Rhizoma rhei and their antilipemic effects.
Orthogonal experiment, UV spectrophotometry and conventional antilipemic effect determination method were used to optimize the extraction process, and to determine the total anthraquinone content, as well as blood levels of total cholesterol, triglycerides, HDL and LDL.
Ethanol concentration, extraction time and ethanol amount had significant influences on the extraction of total Radix et Rhizoma rhei anthraquinones, total Radix et Rhizoma rhei anthraquinones could significantly reduce blood levels of total cholesterol, triglycerides, HDL and LDL.
The optimum extraction process was two times extraction of Radix et Rhizoma rhei with 70% ethanol, the amounts of solvent of 8 folds and 5 folds, successively, and the extraction time of 60 min each. In addition, this extract has an antilipemic effect in mice.</description><subject>Animals</subject><subject>Anthraquinones - administration & dosage</subject><subject>Anthraquinones - analysis</subject><subject>Anthraquinones - isolation & purification</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - analysis</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Hyperlipidemias - metabolism</subject><subject>Hypolipidemic Agents - administration & dosage</subject><subject>Hypolipidemic Agents - analysis</subject><subject>Hypolipidemic Agents - isolation & purification</subject><subject>Male</subject><subject>Mice</subject><subject>Rheum - chemistry</subject><subject>Rhizome - chemistry</subject><issn>2505-0044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLAzEUhYMgtlbX7iRLN1MnN8k8llJ8QUGouh7uJHdoyrw6yUj11zvFujpc-O45nMPYjYiXSgp1j7tgsFl-CeFgCXDG5qBjHcWxUjN26f0ujmUmIL1gM9BK6gRgztr3MNpv3rU8bInTIQxogpvOfugMec-7iocuYM2xDdsB96Nru5Y8dy3foHUHToFvtu6na3BSchNnj15uOH642vXUOMOpqsgEf8XOK6w9XZ90wT6fHj9WL9H67fl19bCOehAiRElWJpnOJClMMYapQi6wtHlCFaJNJRkFIBFNJSAXpU01lDlUmhCsSk0sF-zuz3eqsR_Jh6Jx3lBdY0vd6AuRQK6nBKUm9PaEjmVDtugH1-DwXfxvJH8B2UNpug</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Xie, Hui-Chun</creator><creator>Shang, Jun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Study on the extraction process of total anthraquinones in Radix et Rhizoma Rhei and their antilipemic effects</title><author>Xie, Hui-Chun ; Shang, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-68b68583e4a7a0200491abd96efaad73ec4223aacf1291bd752b92f5ea2d47c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anthraquinones - administration & dosage</topic><topic>Anthraquinones - analysis</topic><topic>Anthraquinones - isolation & purification</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - analysis</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Hyperlipidemias - metabolism</topic><topic>Hypolipidemic Agents - administration & dosage</topic><topic>Hypolipidemic Agents - analysis</topic><topic>Hypolipidemic Agents - isolation & purification</topic><topic>Male</topic><topic>Mice</topic><topic>Rheum - chemistry</topic><topic>Rhizome - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Hui-Chun</creatorcontrib><creatorcontrib>Shang, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Hui-Chun</au><au>Shang, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on the extraction process of total anthraquinones in Radix et Rhizoma Rhei and their antilipemic effects</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><addtitle>Afr J Tradit Complement Altern Med</addtitle><date>2014</date><risdate>2014</risdate><volume>11</volume><issue>2</issue><spage>358</spage><epage>362</epage><pages>358-362</pages><eissn>2505-0044</eissn><abstract>Radix et Rhizoma Rhei has a gastric mucosal protective effect, major anti-gastritis and anti-peptic ulcer active constituents were emodin, aloe-emodin, chrysophanol, rhein, etc. The objective of the study was the extraction process of total anthraquinones in Radix et Rhizoma rhei and their antilipemic effects.
Orthogonal experiment, UV spectrophotometry and conventional antilipemic effect determination method were used to optimize the extraction process, and to determine the total anthraquinone content, as well as blood levels of total cholesterol, triglycerides, HDL and LDL.
Ethanol concentration, extraction time and ethanol amount had significant influences on the extraction of total Radix et Rhizoma rhei anthraquinones, total Radix et Rhizoma rhei anthraquinones could significantly reduce blood levels of total cholesterol, triglycerides, HDL and LDL.
The optimum extraction process was two times extraction of Radix et Rhizoma rhei with 70% ethanol, the amounts of solvent of 8 folds and 5 folds, successively, and the extraction time of 60 min each. In addition, this extract has an antilipemic effect in mice.</abstract><cop>Nigeria</cop><pmid>25435622</pmid><doi>10.4314/ajtcam.v11i2.22</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | African journal of traditional, complementary, and alternative medicines, 2014, Vol.11 (2), p.358-362 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International; PubMed Central |
| subjects | Animals Anthraquinones - administration & dosage Anthraquinones - analysis Anthraquinones - isolation & purification Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - isolation & purification Female Humans Hyperlipidemias - drug therapy Hyperlipidemias - metabolism Hypolipidemic Agents - administration & dosage Hypolipidemic Agents - analysis Hypolipidemic Agents - isolation & purification Male Mice Rheum - chemistry Rhizome - chemistry |
| title | Study on the extraction process of total anthraquinones in Radix et Rhizoma Rhei and their antilipemic effects |
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