The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator

Abstract The AMP-activated protein kinase (AMPK) is a central regulator of cellular metabolism and energy homeostasis in mammalian tissues. Pertinent to cancer biology is the fact that AMPK is situated in the center of a signaling network involving established tumor suppressors including LKB1, TSC2...

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Veröffentlicht in:	Cancer letters 2015-01, Vol.356 (2), p.165-170
Hauptverfasser:	Faubert, Brandon, Vincent, Emma E, Poffenberger, Maya C, Jones, Russell G
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism AMPK Biguanides - pharmacology Cell growth Cell Proliferation Energy Metabolism - physiology Glucose Hematology, Oncology and Palliative Medicine HIF-1α Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Kinases Medical research mTOR Neoplasms - metabolism Oxidative Stress - physiology Protein-Serine-Threonine Kinases - metabolism Rodents Signal Transduction Tumor metabolism Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - metabolism Warburg effect
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