Gonadal hormones influence the immune response to PLP 139–151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis

Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139–1...

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Veröffentlicht in:Journal of neuroimmunology 1998-04, Vol.84 (2), p.122-130
Hauptverfasser: Bebo, Bruce F, Zelinka-Vincent, Edy, Adamus, Grazyna, Amundson, Drake, Vandenbark, Arthur A, Offner, Halina
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Sprache:eng
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