Gonadal hormones influence the immune response to PLP 139–151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis
Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139–1...
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| Veröffentlicht in: | Journal of neuroimmunology 1998-04, Vol.84 (2), p.122-130 |
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| container_end_page | 130 |
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| container_title | Journal of neuroimmunology |
| container_volume | 84 |
| creator | Bebo, Bruce F Zelinka-Vincent, Edy Adamus, Grazyna Amundson, Drake Vandenbark, Arthur A Offner, Halina |
| description | Females have an increased incidence of multiple sclerosis (2:1). This gender dimorphism can be studied effectively using a murine model of relapsing experimental autoimmune encephalomyelitis (R-EAE). We demonstrated previously that male SJL mice immunized with proteolipid protein (PLP) peptide 139–151 developed an initial episode of paralysis, but failed to relapse. In the present study, clinical EAE relapses were induced by orchidectomy. Relapses in castrated mice were accompanied by an influx of activated CD4
+, Th1 cells into the CNS which were absent in sham mice. Our data suggests an important regulatory role for androgens on the immune response to PLP 139–151 and the clinical course of R-EAE. |
| doi_str_mv | 10.1016/S0165-5728(97)00214-2 |
| format | Article |
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| ispartof | Journal of neuroimmunology, 1998-04, Vol.84 (2), p.122-130 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Androgens Orchidectomy Relapsing experimental autoimmune encephalomyelitis |
| title | Gonadal hormones influence the immune response to PLP 139–151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis |
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