Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity

PGCS‐NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1–3 nm) are densely presented. The IV‐injected PGCS‐NPs into EGFR‐expressing tumor‐bearing mice successfully perform targeted and...

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Veröffentlicht in:	Advanced materials (Weinheim) 2014-10, Vol.26 (37), p.6436-6441
Hauptverfasser:	Kwon, Koo Chul, Ryu, Ju Hee, Lee, Jong-Hwan, Lee, Eun Jung, Kwon, Ick Chan, Kim, Kwangmeyung, Lee, Jeewon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - immunology Biocompatibility Biomedical materials Cancer Cell Line, Tumor Cell Survival - drug effects Cetuximab core/shell Gold Gold - chemistry gold nanoparticle Humans In vivo testing In vivo tests Infrared Rays Liver - pathology Mice Mice, Nude Nanoparticles - chemistry nanotoxicity Neoplasms - drug therapy Neoplasms - pathology Particle Size Peptides - chemistry Peptides - metabolism Photochemotherapy Photosensitizing Agents - chemistry Photosensitizing Agents - therapeutic use Photosensitizing Agents - toxicity photothermal therapy proteinticle Receptor, Epidermal Growth Factor - immunology Receptor, Epidermal Growth Factor - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Shells Therapy Transplantation, Heterologous
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