Promyelocytic leukemia cell line, HL-60, produces human hepatocyte growth factor
The human promyelocytic leukemia cell line, HL-60, stimulated with PMA, produced human HGF-like immunoreactivity (HL-60 HGF), which was detected with human HGF-specific ELISA. The purified HL-60 HGF was indistinguishable from human HGF in the plasma of patients with fulminant hepatic failure by stud...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1991-11, Vol.181 (1), p.323-330 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Nishino, Tomoyoshi Kaise, Nobuko Sindo, Yutaka Nishino, Naoki Nishida, Tsutomu Yasuda, Setsuko Masui, Yosihiro |
| description | The human promyelocytic leukemia cell line, HL-60, stimulated with PMA, produced human HGF-like immunoreactivity (HL-60 HGF), which was detected with human HGF-specific ELISA. The purified HL-60 HGF was indistinguishable from human HGF in the plasma of patients with fulminant hepatic failure by studies of subunit constitution and amino acid composition. The HL-60 HGF mRNA corresponded to 6 kb, which was consistent with previous reported data in rat and human HGF mRNA, was detected in stimulated HL-60, by northern hybridization analysis using human HGF cDNA probe. These findings indicated that HL-60 HGF was identical to, or closely resembled, human plasma HGF. The HL-60 cell is an attractive model for studies of HGF-producing mechanisms, the manner of secretion and the nature of induction signals. |
| doi_str_mv | 10.1016/S0006-291X(05)81421-4 |
| format | Article |
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The purified HL-60 HGF was indistinguishable from human HGF in the plasma of patients with fulminant hepatic failure by studies of subunit constitution and amino acid composition. The HL-60 HGF mRNA corresponded to 6 kb, which was consistent with previous reported data in rat and human HGF mRNA, was detected in stimulated HL-60, by northern hybridization analysis using human HGF cDNA probe. These findings indicated that HL-60 HGF was identical to, or closely resembled, human plasma HGF. The HL-60 cell is an attractive model for studies of HGF-producing mechanisms, the manner of secretion and the nature of induction signals.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(05)81421-4</identifier><identifier>PMID: 1720310</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Amino Acids - analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Cell Line ; Cells, Cultured ; Chromatography, High Pressure Liquid ; Culture Media ; DNA Replication - drug effects ; Enzyme-Linked Immunosorbent Assay ; Fundamental and applied biological sciences. Psychology ; Growth Substances - analysis ; Growth Substances - biosynthesis ; Growth Substances - genetics ; Growth Substances - pharmacology ; Hepatocyte Growth Factor ; Humans ; Kinetics ; Leukemia, Promyelocytic, Acute ; Liver - drug effects ; Liver - physiology ; Poly A - genetics ; Poly A - isolation & purification ; Protein hormones. Growth factors. Cytokines ; Proteins ; Rats ; RNA - genetics ; RNA - isolation & purification ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; Tetradecanoylphorbol Acetate - pharmacology</subject><ispartof>Biochemical and biophysical research communications, 1991-11, Vol.181 (1), p.323-330</ispartof><rights>1991 Academic Press, Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-386b437ba92bb615716825d33f36479f0f55c43d472a4780e6a002cbece834743</citedby><cites>FETCH-LOGICAL-c420t-386b437ba92bb615716825d33f36479f0f55c43d472a4780e6a002cbece834743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X05814214$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5016124$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1720310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishino, Tomoyoshi</creatorcontrib><creatorcontrib>Kaise, Nobuko</creatorcontrib><creatorcontrib>Sindo, Yutaka</creatorcontrib><creatorcontrib>Nishino, Naoki</creatorcontrib><creatorcontrib>Nishida, Tsutomu</creatorcontrib><creatorcontrib>Yasuda, Setsuko</creatorcontrib><creatorcontrib>Masui, Yosihiro</creatorcontrib><title>Promyelocytic leukemia cell line, HL-60, produces human hepatocyte growth factor</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The human promyelocytic leukemia cell line, HL-60, stimulated with PMA, produced human HGF-like immunoreactivity (HL-60 HGF), which was detected with human HGF-specific ELISA. The purified HL-60 HGF was indistinguishable from human HGF in the plasma of patients with fulminant hepatic failure by studies of subunit constitution and amino acid composition. The HL-60 HGF mRNA corresponded to 6 kb, which was consistent with previous reported data in rat and human HGF mRNA, was detected in stimulated HL-60, by northern hybridization analysis using human HGF cDNA probe. These findings indicated that HL-60 HGF was identical to, or closely resembled, human plasma HGF. The HL-60 cell is an attractive model for studies of HGF-producing mechanisms, the manner of secretion and the nature of induction signals.</description><subject>Amino Acids - analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cells, Cultured</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Culture Media</subject><subject>DNA Replication - drug effects</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Substances - analysis</subject><subject>Growth Substances - biosynthesis</subject><subject>Growth Substances - genetics</subject><subject>Growth Substances - pharmacology</subject><subject>Hepatocyte Growth Factor</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Leukemia, Promyelocytic, Acute</subject><subject>Liver - drug effects</subject><subject>Liver - physiology</subject><subject>Poly A - genetics</subject><subject>Poly A - isolation & purification</subject><subject>Protein hormones. Growth factors. Cytokines</subject><subject>Proteins</subject><subject>Rats</subject><subject>RNA - genetics</subject><subject>RNA - isolation & purification</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - genetics</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq0KRBfan4DkA0JFIu2M7TjJqaoQFKSVQCpIvVmOM-m65GOxk6L99yTsih45-TDPvPP6YewY4SsC6m-_AEAnosDfXyA9y1EJTNQHtkAoIBEIao8t3pCP7DDGvwCIShcH7AAzARJhwe7uQt9uqOndZvCONzQ-Uustd9Q0vPEdnfPrZaLhnK9DX42OIl-Nre34itZ2mLeI_wn987DitXVDHz6x_do2kT7v3iP2cHV5f3GdLG9_3lz8WCZOCRgSmetSyay0hShLjWmGOhdpJWUttcqKGuo0dUpWKhNWZTmQtgDCleQolypT8oidbnOnXk8jxcG0Ps6tbUf9GA3q6d9Flk9gugVd6GMMVJt18K0NG4NgZpPm1aSZNRlIzatJMx843h0Yy5aq_1tbddP8ZDe30dmmDrZzPr5h6ZSMYo75vsVokvHPUzDReeocVT6QG0zV-3eKvAA2Do44</recordid><startdate>19911127</startdate><enddate>19911127</enddate><creator>Nishino, Tomoyoshi</creator><creator>Kaise, Nobuko</creator><creator>Sindo, Yutaka</creator><creator>Nishino, Naoki</creator><creator>Nishida, Tsutomu</creator><creator>Yasuda, Setsuko</creator><creator>Masui, Yosihiro</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19911127</creationdate><title>Promyelocytic leukemia cell line, HL-60, produces human hepatocyte growth factor</title><author>Nishino, Tomoyoshi ; Kaise, Nobuko ; Sindo, Yutaka ; Nishino, Naoki ; Nishida, Tsutomu ; Yasuda, Setsuko ; Masui, Yosihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-386b437ba92bb615716825d33f36479f0f55c43d472a4780e6a002cbece834743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amino Acids - analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cells, Cultured</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Culture Media</topic><topic>DNA Replication - drug effects</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Substances - analysis</topic><topic>Growth Substances - biosynthesis</topic><topic>Growth Substances - genetics</topic><topic>Growth Substances - pharmacology</topic><topic>Hepatocyte Growth Factor</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Leukemia, Promyelocytic, Acute</topic><topic>Liver - drug effects</topic><topic>Liver - physiology</topic><topic>Poly A - genetics</topic><topic>Poly A - isolation & purification</topic><topic>Protein hormones. Growth factors. Cytokines</topic><topic>Proteins</topic><topic>Rats</topic><topic>RNA - genetics</topic><topic>RNA - isolation & purification</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - genetics</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishino, Tomoyoshi</creatorcontrib><creatorcontrib>Kaise, Nobuko</creatorcontrib><creatorcontrib>Sindo, Yutaka</creatorcontrib><creatorcontrib>Nishino, Naoki</creatorcontrib><creatorcontrib>Nishida, Tsutomu</creatorcontrib><creatorcontrib>Yasuda, Setsuko</creatorcontrib><creatorcontrib>Masui, Yosihiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishino, Tomoyoshi</au><au>Kaise, Nobuko</au><au>Sindo, Yutaka</au><au>Nishino, Naoki</au><au>Nishida, Tsutomu</au><au>Yasuda, Setsuko</au><au>Masui, Yosihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Promyelocytic leukemia cell line, HL-60, produces human hepatocyte growth factor</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1991-11-27</date><risdate>1991</risdate><volume>181</volume><issue>1</issue><spage>323</spage><epage>330</epage><pages>323-330</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The human promyelocytic leukemia cell line, HL-60, stimulated with PMA, produced human HGF-like immunoreactivity (HL-60 HGF), which was detected with human HGF-specific ELISA. The purified HL-60 HGF was indistinguishable from human HGF in the plasma of patients with fulminant hepatic failure by studies of subunit constitution and amino acid composition. The HL-60 HGF mRNA corresponded to 6 kb, which was consistent with previous reported data in rat and human HGF mRNA, was detected in stimulated HL-60, by northern hybridization analysis using human HGF cDNA probe. These findings indicated that HL-60 HGF was identical to, or closely resembled, human plasma HGF. The HL-60 cell is an attractive model for studies of HGF-producing mechanisms, the manner of secretion and the nature of induction signals.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1720310</pmid><doi>10.1016/S0006-291X(05)81421-4</doi><tpages>8</tpages></addata></record> |
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| subjects | Amino Acids - analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Line Cells, Cultured Chromatography, High Pressure Liquid Culture Media DNA Replication - drug effects Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Growth Substances - analysis Growth Substances - biosynthesis Growth Substances - genetics Growth Substances - pharmacology Hepatocyte Growth Factor Humans Kinetics Leukemia, Promyelocytic, Acute Liver - drug effects Liver - physiology Poly A - genetics Poly A - isolation & purification Protein hormones. Growth factors. Cytokines Proteins Rats RNA - genetics RNA - isolation & purification RNA, Messenger - analysis RNA, Messenger - genetics Tetradecanoylphorbol Acetate - pharmacology |
| title | Promyelocytic leukemia cell line, HL-60, produces human hepatocyte growth factor |
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