Norepinephrine transmitter metabolite generates free radicals and activates mitochondrial permeability transition: a mechanism for DOPEGAL-induced apoptosis

3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine (NE) and epinephrine. DOPEGAL, but neither NE nor its other metabolites induces apoptosis in differentiated PC-12 cells by an unknown mechanism. To study the mechanism of DOPEGAL-induced apoptosis, we...

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Veröffentlicht in:	Brain research 1998-03, Vol.787 (2), p.328-332
Hauptverfasser:	Burke, William J., Kristal, Bruce S., Yu, Byung P., Li, Shu Wen, Lin, Tien-Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylglycolaldehyde Ageing, cell death Aldehydes - toxicity Alzheimer's disease Animals Apoptosis Apoptosis - drug effects Biological and medical sciences Calcium - physiology Cell physiology Electron Spin Resonance Spectroscopy Free Radicals - metabolism Fundamental and applied biological sciences. Psychology Male Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondrial permeability transition Molecular and cellular biology Neurotoxin Norepinephrine - metabolism Oxidative Stress - physiology PC12 Cells Permeability Rats Rats, Inbred F344
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