Pharmacological investigation of oedema induced by venom from the wasp Polistes fuscatus
Subplantar injection of Polistes fuscatus venom induced dose-dependent rat hindpaw oedema. The oedema was significant in the first hour and reached maximum size in the fifth hour after injection of the venom (20–600 μg/paw). Low doses of the venom (20–80 μg/paw) produced oedema which disappeared wit...
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| Veröffentlicht in: | Toxicon (Oxford) 1997-12, Vol.35 (12), p.1691-1698 |
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| container_title | Toxicon (Oxford) |
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| creator | Eno, A.E. |
| description | Subplantar injection of
Polistes fuscatus venom induced dose-dependent rat hindpaw oedema. The oedema was significant in the first hour and reached maximum size in the fifth hour after injection of the venom (20–600 μg/paw). Low doses of the venom (20–80 μg/paw) produced oedema which disappeared within 48 hr after injection, while at doses of 300–600 μg/paw, oedema was present in excess of 48 hr. Pharmacological studies suggested that
P. fuscatus venom-induced oedema probably has a mechanism which is multimediated. Pretreatment of rats with a combination of cyproheptadine (5 mg/kg)- captopril (2 mg/kg)- dexamethasone (1 mg/kg) inhibited the formation of oedema (maximal swelling) produced by the venom (300 μg/paw) by about 79% and improved the time to recovery. Paw swellings caused by 20 and 40 μg/paw venom were completely eliminated by the same doses of this drug combination. The kinins, autacoids (histamine and serotonin) and lipogenase derivatives are probably involved in the venom-induced oedema. |
| doi_str_mv | 10.1016/S0041-0101(97)00018-4 |
| format | Article |
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Polistes fuscatus venom induced dose-dependent rat hindpaw oedema. The oedema was significant in the first hour and reached maximum size in the fifth hour after injection of the venom (20–600 μg/paw). Low doses of the venom (20–80 μg/paw) produced oedema which disappeared within 48 hr after injection, while at doses of 300–600 μg/paw, oedema was present in excess of 48 hr. Pharmacological studies suggested that
P. fuscatus venom-induced oedema probably has a mechanism which is multimediated. Pretreatment of rats with a combination of cyproheptadine (5 mg/kg)- captopril (2 mg/kg)- dexamethasone (1 mg/kg) inhibited the formation of oedema (maximal swelling) produced by the venom (300 μg/paw) by about 79% and improved the time to recovery. Paw swellings caused by 20 and 40 μg/paw venom were completely eliminated by the same doses of this drug combination. The kinins, autacoids (histamine and serotonin) and lipogenase derivatives are probably involved in the venom-induced oedema.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/S0041-0101(97)00018-4</identifier><identifier>PMID: 9481811</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animal poisons toxicology. Antivenoms ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Captopril - therapeutic use ; Cyproheptadine - therapeutic use ; Dexamethasone - therapeutic use ; Edema - chemically induced ; Edema - drug therapy ; Histamine Antagonists - therapeutic use ; Medical sciences ; Rats ; Rats, Wistar ; Serotonin Antagonists - therapeutic use ; Toxicology ; Wasp Venoms - toxicity ; Wasps</subject><ispartof>Toxicon (Oxford), 1997-12, Vol.35 (12), p.1691-1698</ispartof><rights>1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-b915959fbb7bc456d45ab98ceb1c551a699377c888c844221f024847f59e9c143</citedby><cites>FETCH-LOGICAL-c389t-b915959fbb7bc456d45ab98ceb1c551a699377c888c844221f024847f59e9c143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041010197000184$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2146924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9481811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eno, A.E.</creatorcontrib><title>Pharmacological investigation of oedema induced by venom from the wasp Polistes fuscatus</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Subplantar injection of
Polistes fuscatus venom induced dose-dependent rat hindpaw oedema. The oedema was significant in the first hour and reached maximum size in the fifth hour after injection of the venom (20–600 μg/paw). Low doses of the venom (20–80 μg/paw) produced oedema which disappeared within 48 hr after injection, while at doses of 300–600 μg/paw, oedema was present in excess of 48 hr. Pharmacological studies suggested that
P. fuscatus venom-induced oedema probably has a mechanism which is multimediated. Pretreatment of rats with a combination of cyproheptadine (5 mg/kg)- captopril (2 mg/kg)- dexamethasone (1 mg/kg) inhibited the formation of oedema (maximal swelling) produced by the venom (300 μg/paw) by about 79% and improved the time to recovery. Paw swellings caused by 20 and 40 μg/paw venom were completely eliminated by the same doses of this drug combination. The kinins, autacoids (histamine and serotonin) and lipogenase derivatives are probably involved in the venom-induced oedema.</description><subject>Animal poisons toxicology. Antivenoms</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Captopril - therapeutic use</subject><subject>Cyproheptadine - therapeutic use</subject><subject>Dexamethasone - therapeutic use</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Histamine Antagonists - therapeutic use</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serotonin Antagonists - therapeutic use</subject><subject>Toxicology</subject><subject>Wasp Venoms - toxicity</subject><subject>Wasps</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9r2zAUgMVY6dK0f0JAhzHWg1s9R7Kl0xil3QaFFrZCb0KWnxIN28okO6X_fZUm5LqLJN773g99hCyAXQGD6vo3YxwKlt9fVX3JGANZ8A9kBrJWxRIE-0hmR-QTOUvpb4aWUlWn5FRxCRJgRp4f1yb2xoYurLw1HfXDFtPoV2b0YaDB0YAt9ibH28liS5tXusUh9NTFfIxrpC8mbehj6HwaMVE3JWvGKZ2TE2e6hBeHe06e7m7_3Pws7h9-_Lr5fl_YvMpYNAqEEso1Td1YLqqWC9MoabEBKwSYSqllXVsppZWclyU4VnLJaycUKgt8OSdf9n03Mfyb8uq698li15kBw5Q0VGUuVlUGxR60MaQU0elN9L2JrxqY3hnV70b1TpdWtX43qncDFocBU9Nje6w6KMz5z4e8yT_vXDSD9emIlcArVe7afNtjmGVsPUadrMchK_UR7ajb4P-zyBs2fZIt</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Eno, A.E.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19971201</creationdate><title>Pharmacological investigation of oedema induced by venom from the wasp Polistes fuscatus</title><author>Eno, A.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-b915959fbb7bc456d45ab98ceb1c551a699377c888c844221f024847f59e9c143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animal poisons toxicology. Antivenoms</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Captopril - therapeutic use</topic><topic>Cyproheptadine - therapeutic use</topic><topic>Dexamethasone - therapeutic use</topic><topic>Edema - chemically induced</topic><topic>Edema - drug therapy</topic><topic>Histamine Antagonists - therapeutic use</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Serotonin Antagonists - therapeutic use</topic><topic>Toxicology</topic><topic>Wasp Venoms - toxicity</topic><topic>Wasps</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eno, A.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eno, A.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological investigation of oedema induced by venom from the wasp Polistes fuscatus</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>35</volume><issue>12</issue><spage>1691</spage><epage>1698</epage><pages>1691-1698</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>Subplantar injection of
Polistes fuscatus venom induced dose-dependent rat hindpaw oedema. The oedema was significant in the first hour and reached maximum size in the fifth hour after injection of the venom (20–600 μg/paw). Low doses of the venom (20–80 μg/paw) produced oedema which disappeared within 48 hr after injection, while at doses of 300–600 μg/paw, oedema was present in excess of 48 hr. Pharmacological studies suggested that
P. fuscatus venom-induced oedema probably has a mechanism which is multimediated. Pretreatment of rats with a combination of cyproheptadine (5 mg/kg)- captopril (2 mg/kg)- dexamethasone (1 mg/kg) inhibited the formation of oedema (maximal swelling) produced by the venom (300 μg/paw) by about 79% and improved the time to recovery. Paw swellings caused by 20 and 40 μg/paw venom were completely eliminated by the same doses of this drug combination. The kinins, autacoids (histamine and serotonin) and lipogenase derivatives are probably involved in the venom-induced oedema.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9481811</pmid><doi>10.1016/S0041-0101(97)00018-4</doi><tpages>8</tpages></addata></record> |
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| ispartof | Toxicon (Oxford), 1997-12, Vol.35 (12), p.1691-1698 |
| issn | 0041-0101 1879-3150 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animal poisons toxicology. Antivenoms Animals Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Captopril - therapeutic use Cyproheptadine - therapeutic use Dexamethasone - therapeutic use Edema - chemically induced Edema - drug therapy Histamine Antagonists - therapeutic use Medical sciences Rats Rats, Wistar Serotonin Antagonists - therapeutic use Toxicology Wasp Venoms - toxicity Wasps |
| title | Pharmacological investigation of oedema induced by venom from the wasp Polistes fuscatus |
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