Induction therapy with short-term high-dose intravenous cyclophosphamide followed by mycophenolate mofetil in proliferative lupus nephritis

For decades, high-dose intravenous cyclophosphamide (ivCY) given for 24-30 months was regarded as the standard therapy for proliferative lupus nephritis, despite serious side effects. Our aim was to evaluate the effect of induction therapy with short-term high-dose ivCY followed by mycophenolate mof...

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Veröffentlicht in:	Netherlands journal of medicine 2014-11, Vol.72 (9), p.481-490
Hauptverfasser:	Arends, S, Berden, J H M, Grootscholten, C, Derksen, R H W M, Berger, S P, de Sévaux, R G L, Voskuyl, A E, Bijl, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adult Anti-Inflammatory Agents - therapeutic use Azathioprine - therapeutic use Cyclophosphamide - administration & dosage Drug Therapy, Combination Female Humans Immunosuppressive Agents - administration & dosage Induction Chemotherapy - methods Kidney Failure, Chronic - etiology Lupus Nephritis - complications Lupus Nephritis - drug therapy Male Middle Aged Mycophenolic Acid - administration & dosage Mycophenolic Acid - analogs & derivatives Prednisone - therapeutic use Quality of Life Recurrence Survival Rate Young Adult
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