The Apoptotic Initiator Caspase-8: Its Functional Ubiquity and Genetic Diversity during Animal Evolution

The caspases, a family of cysteine proteases, play multiple roles in apoptosis, inflammation, and cellular differentiation. Caspase-8 (Casp8), which was first identified in humans, functions as an initiator caspase in the apoptotic signaling mediated by cell-surface death receptors. To understand th...

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Veröffentlicht in:	Molecular biology and evolution 2014-12, Vol.31 (12), p.3282-3301
Hauptverfasser:	Sakamaki, Kazuhiro, Shimizu, Kouhei, Iwata, Hiroaki, Imai, Kenichiro, Satou, Yutaka, Funayama, Noriko, Nozaki, Masami, Yajima, Mamiko, Nishimura, Osamu, Higuchi, Mayura, Chiba, Kumiko, Yoshimoto, Michi, Kimura, Haruna, Gracey, Andrew Y., Shimizu, Takashi, Tomii, Kentaro, Gotoh, Osamu, Akasaka, Koji, Sawasaki, Tatsuya, Miller, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Annelida - genetics Anthozoa - genetics Apoptosis Base Sequence Caspase 8 - chemistry Caspase 8 - genetics Ciona intestinalis - genetics Enzymatic activity Evolution Evolution, Molecular Fish Proteins - genetics Fishes - genetics Genetic diversity HeLa Cells Humans Mammals Molecular Sequence Data Mortality Mytilus - genetics Phylogeny Planarians - genetics Proteases Protein Conformation Proteins Substrate Specificity
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