Metastatic melanoma of the tongue: a case report with immunohistochemical profile
Background Melanoma of the skin is characterised by a high metastatic potential, but reports of metastasis to the tongue are rare. We report a case of skin melanoma with metastasis to the lymph nodes, tongue and brain. Objectives This report highlights the clinical and histological features of oral...
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| Veröffentlicht in: | Gerodontology 2014-12, Vol.31 (4), p.314-319 |
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| creator | Alves, Mônica Ghislaine O. Chagas, Luciene R. Carvalho, Yasmin R. Cabral, Luiz A. G. Coletta, Ricardo D. Almeida, Janete D. |
| description | Background
Melanoma of the skin is characterised by a high metastatic potential, but reports of metastasis to the tongue are rare. We report a case of skin melanoma with metastasis to the lymph nodes, tongue and brain.
Objectives
This report highlights the clinical and histological features of oral metastatic melanoma.
Case report
A 72‐year‐old man was seen with a nodule on the tongue. The differential diagnosis included salivary gland tumour, lymphoma and metastatic melanoma. His medical history revealed treatment for melanoma in the periumbilical region and micrometastases in the inguinal lymph nodes. An incisional biopsy was obtained and histological analysis showed the presence of a solid, epithelioid malignant tumour of monotonous appearance infiltrating the skeletal musculature. Immunohistochemistry showed reactivity of neoplastic cells to anti‐HMB45, anti‐melan A and anti‐S100 antibodies and negativity for anti‐PAN cytokeratin, confirming the diagnosis of metastatic melanoma.
Conclusion
The present findings highlight the importance of a complete medical evaluation of the patient by anamnesis to identify possible oral repercussions of primary diseases in other organs and/or systems. |
| doi_str_mv | 10.1111/ger.12032 |
| format | Article |
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Melanoma of the skin is characterised by a high metastatic potential, but reports of metastasis to the tongue are rare. We report a case of skin melanoma with metastasis to the lymph nodes, tongue and brain.
Objectives
This report highlights the clinical and histological features of oral metastatic melanoma.
Case report
A 72‐year‐old man was seen with a nodule on the tongue. The differential diagnosis included salivary gland tumour, lymphoma and metastatic melanoma. His medical history revealed treatment for melanoma in the periumbilical region and micrometastases in the inguinal lymph nodes. An incisional biopsy was obtained and histological analysis showed the presence of a solid, epithelioid malignant tumour of monotonous appearance infiltrating the skeletal musculature. Immunohistochemistry showed reactivity of neoplastic cells to anti‐HMB45, anti‐melan A and anti‐S100 antibodies and negativity for anti‐PAN cytokeratin, confirming the diagnosis of metastatic melanoma.
Conclusion
The present findings highlight the importance of a complete medical evaluation of the patient by anamnesis to identify possible oral repercussions of primary diseases in other organs and/or systems.</description><identifier>ISSN: 0734-0664</identifier><identifier>EISSN: 1741-2358</identifier><identifier>DOI: 10.1111/ger.12032</identifier><identifier>PMID: 25427453</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Brain Neoplasms - secondary ; Dentistry ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Lymphatic Metastasis - diagnosis ; Male ; MART-1 Antigen - analysis ; melanoma ; Melanoma - pathology ; Melanoma - secondary ; Melanoma-Specific Antigens - analysis ; oral cancer ; oral mucosa ; S100 Proteins - analysis ; skin cancer ; Skin Neoplasms - pathology ; Tongue Neoplasms - secondary</subject><ispartof>Gerodontology, 2014-12, Vol.31 (4), p.314-319</ispartof><rights>2014 John Wiley & Sons A/S and The Gerodontology Association. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S and The Gerodontology Association. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3252-115e4a04898bcb2cc0868e077f1a1c213436b8ad4980e5ee98e87d3783f055e23</citedby><cites>FETCH-LOGICAL-c3252-115e4a04898bcb2cc0868e077f1a1c213436b8ad4980e5ee98e87d3783f055e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fger.12032$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fger.12032$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25427453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alves, Mônica Ghislaine O.</creatorcontrib><creatorcontrib>Chagas, Luciene R.</creatorcontrib><creatorcontrib>Carvalho, Yasmin R.</creatorcontrib><creatorcontrib>Cabral, Luiz A. G.</creatorcontrib><creatorcontrib>Coletta, Ricardo D.</creatorcontrib><creatorcontrib>Almeida, Janete D.</creatorcontrib><title>Metastatic melanoma of the tongue: a case report with immunohistochemical profile</title><title>Gerodontology</title><addtitle>Gerodontology</addtitle><description>Background
Melanoma of the skin is characterised by a high metastatic potential, but reports of metastasis to the tongue are rare. We report a case of skin melanoma with metastasis to the lymph nodes, tongue and brain.
Objectives
This report highlights the clinical and histological features of oral metastatic melanoma.
Case report
A 72‐year‐old man was seen with a nodule on the tongue. The differential diagnosis included salivary gland tumour, lymphoma and metastatic melanoma. His medical history revealed treatment for melanoma in the periumbilical region and micrometastases in the inguinal lymph nodes. An incisional biopsy was obtained and histological analysis showed the presence of a solid, epithelioid malignant tumour of monotonous appearance infiltrating the skeletal musculature. Immunohistochemistry showed reactivity of neoplastic cells to anti‐HMB45, anti‐melan A and anti‐S100 antibodies and negativity for anti‐PAN cytokeratin, confirming the diagnosis of metastatic melanoma.
Conclusion
The present findings highlight the importance of a complete medical evaluation of the patient by anamnesis to identify possible oral repercussions of primary diseases in other organs and/or systems.</description><subject>Aged</subject><subject>Brain Neoplasms - secondary</subject><subject>Dentistry</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Male</subject><subject>MART-1 Antigen - analysis</subject><subject>melanoma</subject><subject>Melanoma - pathology</subject><subject>Melanoma - secondary</subject><subject>Melanoma-Specific Antigens - analysis</subject><subject>oral cancer</subject><subject>oral mucosa</subject><subject>S100 Proteins - analysis</subject><subject>skin cancer</subject><subject>Skin Neoplasms - pathology</subject><subject>Tongue Neoplasms - secondary</subject><issn>0734-0664</issn><issn>1741-2358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQQC0EoqUw8AeQRxjS-jNx2VBVClIRAsEcOe6lCYrrEjuq-u8xpLBxyy1P73QPoUtKxjTOZA3tmDLC2REa0kzQhHGpjtGQZFwkJE3FAJ15_0EIkxnjp2jApGCZkHyIXp4gaB90qA220OiNsxq7EocKcHCbdQe3WGOjPeAWtq4NeFeHCtfWdhtX1T44U4GtjW7wtnVl3cA5Oil14-HisEfo_X7-NntIls-Lx9ndMjGcSZZQKkFoItRUFaZgxhCVKiBZVlJNDaNc8LRQeiWmioAEmCpQ2YpnipdESmB8hK57b7z72YEPua29gSb-AK7zOU2ZUorwGGGEbnrUtM77Fsp829ZWt_uckvy7YB4L5j8FI3t10HaFhdUf-ZssApMe2MVn9_-b8sX8tVd-AcH9edw</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Alves, Mônica Ghislaine O.</creator><creator>Chagas, Luciene R.</creator><creator>Carvalho, Yasmin R.</creator><creator>Cabral, Luiz A. G.</creator><creator>Coletta, Ricardo D.</creator><creator>Almeida, Janete D.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201412</creationdate><title>Metastatic melanoma of the tongue: a case report with immunohistochemical profile</title><author>Alves, Mônica Ghislaine O. ; Chagas, Luciene R. ; Carvalho, Yasmin R. ; Cabral, Luiz A. G. ; Coletta, Ricardo D. ; Almeida, Janete D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3252-115e4a04898bcb2cc0868e077f1a1c213436b8ad4980e5ee98e87d3783f055e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Brain Neoplasms - secondary</topic><topic>Dentistry</topic><topic>Diagnosis, Differential</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Male</topic><topic>MART-1 Antigen - analysis</topic><topic>melanoma</topic><topic>Melanoma - pathology</topic><topic>Melanoma - secondary</topic><topic>Melanoma-Specific Antigens - analysis</topic><topic>oral cancer</topic><topic>oral mucosa</topic><topic>S100 Proteins - analysis</topic><topic>skin cancer</topic><topic>Skin Neoplasms - pathology</topic><topic>Tongue Neoplasms - secondary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alves, Mônica Ghislaine O.</creatorcontrib><creatorcontrib>Chagas, Luciene R.</creatorcontrib><creatorcontrib>Carvalho, Yasmin R.</creatorcontrib><creatorcontrib>Cabral, Luiz A. G.</creatorcontrib><creatorcontrib>Coletta, Ricardo D.</creatorcontrib><creatorcontrib>Almeida, Janete D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gerodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alves, Mônica Ghislaine O.</au><au>Chagas, Luciene R.</au><au>Carvalho, Yasmin R.</au><au>Cabral, Luiz A. G.</au><au>Coletta, Ricardo D.</au><au>Almeida, Janete D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metastatic melanoma of the tongue: a case report with immunohistochemical profile</atitle><jtitle>Gerodontology</jtitle><addtitle>Gerodontology</addtitle><date>2014-12</date><risdate>2014</risdate><volume>31</volume><issue>4</issue><spage>314</spage><epage>319</epage><pages>314-319</pages><issn>0734-0664</issn><eissn>1741-2358</eissn><abstract>Background
Melanoma of the skin is characterised by a high metastatic potential, but reports of metastasis to the tongue are rare. We report a case of skin melanoma with metastasis to the lymph nodes, tongue and brain.
Objectives
This report highlights the clinical and histological features of oral metastatic melanoma.
Case report
A 72‐year‐old man was seen with a nodule on the tongue. The differential diagnosis included salivary gland tumour, lymphoma and metastatic melanoma. His medical history revealed treatment for melanoma in the periumbilical region and micrometastases in the inguinal lymph nodes. An incisional biopsy was obtained and histological analysis showed the presence of a solid, epithelioid malignant tumour of monotonous appearance infiltrating the skeletal musculature. Immunohistochemistry showed reactivity of neoplastic cells to anti‐HMB45, anti‐melan A and anti‐S100 antibodies and negativity for anti‐PAN cytokeratin, confirming the diagnosis of metastatic melanoma.
Conclusion
The present findings highlight the importance of a complete medical evaluation of the patient by anamnesis to identify possible oral repercussions of primary diseases in other organs and/or systems.</abstract><cop>England</cop><pmid>25427453</pmid><doi>10.1111/ger.12032</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged Brain Neoplasms - secondary Dentistry Diagnosis, Differential Humans Immunohistochemistry Lymphatic Metastasis - diagnosis Male MART-1 Antigen - analysis melanoma Melanoma - pathology Melanoma - secondary Melanoma-Specific Antigens - analysis oral cancer oral mucosa S100 Proteins - analysis skin cancer Skin Neoplasms - pathology Tongue Neoplasms - secondary |
| title | Metastatic melanoma of the tongue: a case report with immunohistochemical profile |
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