Reproducibility of histological subtyping of malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) has a very poor prognosis. Although clinical stage is currently the only reliable prognostic factor, histologic subtyping reportedly also affects prognosis. Some studies propose reclassification of pleomorphic epithelioid as biphasic or sarcomatoid MPM. This stud...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2014-12, Vol.465 (6), p.679-685 |
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| container_title | Virchows Archiv : an international journal of pathology |
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| creator | Brčić, Luka Jakopović, Marko Brčić, Iva Klarić, Vlasta Milošević, Milan Šepac, Ana Samaržija, Miroslav Seiwerth, Sven |
| description | Malignant pleural mesothelioma (MPM) has a very poor prognosis. Although clinical stage is currently the only reliable prognostic factor, histologic subtyping reportedly also affects prognosis. Some studies propose reclassification of pleomorphic epithelioid as biphasic or sarcomatoid MPM. This study assessed prognostic significance and interobserver agreement in MPM subtyping of small biopsy specimens. We analyzed biopsy specimens, and clinical and survival data from records of 108 patients who were diagnosed between 2000 and 2010 at the Institute of Pathology University of Zagreb School of Medicine, of whom 98 had epithelioid MPM, six biphasic MPM, and four sarcomatoid MPM. Among epithelioid subtypes, 44 (44.9 %) were solid, 19 (19.4 %) tubulopapillary, 18 (18.4 %) acinar, six (6.1 %) adenomatoid, five (5.1 %) pleomorphic, four (4.1 %) trabecular, and two (2.0 %) micropapillary subtype. Interobserver reliability for histological diagnosis was found to be
κ
= 0.72 (
P
|
| doi_str_mv | 10.1007/s00428-014-1664-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1628878927</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1628878927</sourcerecordid><originalsourceid>FETCH-LOGICAL-c551t-bf141bbe03cafebf11fdab35035bf087b9faec9e79bae46f7dd2284e640663773</originalsourceid><addsrcrecordid>eNp1kMFqGzEQhkVpqR23D9BLMeSSy6YaSSvtHoNpkxBDoLRnIe2ObBntylntHvz2kWsnhEBPYvi_-TV8hHwDeg2Uqh-JUsGqgoIoQEpR1B_IHARnBeNUfSRzWouykBzUjFyktKOUQQXyM5mxkueB1XPy8Bv3Q2ynxlsf_HhYRrfc-jTGEDe-MWGZJjse9r7fHJPOBL_pTT8u9wGnIccdpjhuMfjYmS_kkzMh4dfzuyB_f_38s7or1o-396ubddGUJYyFdSDAWqS8MQ7zBK41lpeUl9bRStnaGWxqVLU1KKRTbctYJVAKKiVXii_I1ak3X_40YRp151ODIZge45Q0SFZVqqrZEb18h-7iNPT5un8UKAmUZQpOVDPElAZ0ej_4zgwHDVQfTeuTaZ1N66NpXeed7-fmyXbYvm68qM0AOwEpR_0Ghzdf_7f1GUa8igA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1628176102</pqid></control><display><type>article</type><title>Reproducibility of histological subtyping of malignant pleural mesothelioma</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Brčić, Luka ; Jakopović, Marko ; Brčić, Iva ; Klarić, Vlasta ; Milošević, Milan ; Šepac, Ana ; Samaržija, Miroslav ; Seiwerth, Sven</creator><creatorcontrib>Brčić, Luka ; Jakopović, Marko ; Brčić, Iva ; Klarić, Vlasta ; Milošević, Milan ; Šepac, Ana ; Samaržija, Miroslav ; Seiwerth, Sven</creatorcontrib><description>Malignant pleural mesothelioma (MPM) has a very poor prognosis. Although clinical stage is currently the only reliable prognostic factor, histologic subtyping reportedly also affects prognosis. Some studies propose reclassification of pleomorphic epithelioid as biphasic or sarcomatoid MPM. This study assessed prognostic significance and interobserver agreement in MPM subtyping of small biopsy specimens. We analyzed biopsy specimens, and clinical and survival data from records of 108 patients who were diagnosed between 2000 and 2010 at the Institute of Pathology University of Zagreb School of Medicine, of whom 98 had epithelioid MPM, six biphasic MPM, and four sarcomatoid MPM. Among epithelioid subtypes, 44 (44.9 %) were solid, 19 (19.4 %) tubulopapillary, 18 (18.4 %) acinar, six (6.1 %) adenomatoid, five (5.1 %) pleomorphic, four (4.1 %) trabecular, and two (2.0 %) micropapillary subtype. Interobserver reliability for histological diagnosis was found to be
κ
= 0.72 (
P
< 0.001). Median overall survival for epithelioid MPM was 10.5 months with an interquartile range (IQR) of 5.8–28.0 months but significantly shorter for the pleomorphic subtype (3 [IQR 3.0–8.0] months;
P
= 0.034), but not significantly different from biphasic (6.5 [IQR 3.5–15.3] months) and sarcomatoid mesothelioma (4.0 [IQR 1.3–6.8] months;
P
= 0.270). We found strong reproducibility of MPM subtyping with good interobserver agreement. Furthermore, our results indicate that pleomorphic subtype to be a predictor of poor prognosis and support classifying it with sarcomatoid or biphasic MPM, as patients with the pleomorphic, biphasic, or sarcomatoid subtype show similarly poor overall survival.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-014-1664-9</identifier><identifier>PMID: 25300229</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Medicine ; Medicine & Public Health ; Mesothelioma ; Mesothelioma - mortality ; Mesothelioma - pathology ; Middle Aged ; Observer Variation ; Original Article ; Pathology ; Pleural Neoplasms - mortality ; Pleural Neoplasms - pathology ; Prognosis ; Reproducibility of Results</subject><ispartof>Virchows Archiv : an international journal of pathology, 2014-12, Vol.465 (6), p.679-685</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-bf141bbe03cafebf11fdab35035bf087b9faec9e79bae46f7dd2284e640663773</citedby><cites>FETCH-LOGICAL-c551t-bf141bbe03cafebf11fdab35035bf087b9faec9e79bae46f7dd2284e640663773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-014-1664-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-014-1664-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25300229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brčić, Luka</creatorcontrib><creatorcontrib>Jakopović, Marko</creatorcontrib><creatorcontrib>Brčić, Iva</creatorcontrib><creatorcontrib>Klarić, Vlasta</creatorcontrib><creatorcontrib>Milošević, Milan</creatorcontrib><creatorcontrib>Šepac, Ana</creatorcontrib><creatorcontrib>Samaržija, Miroslav</creatorcontrib><creatorcontrib>Seiwerth, Sven</creatorcontrib><title>Reproducibility of histological subtyping of malignant pleural mesothelioma</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>Malignant pleural mesothelioma (MPM) has a very poor prognosis. Although clinical stage is currently the only reliable prognostic factor, histologic subtyping reportedly also affects prognosis. Some studies propose reclassification of pleomorphic epithelioid as biphasic or sarcomatoid MPM. This study assessed prognostic significance and interobserver agreement in MPM subtyping of small biopsy specimens. We analyzed biopsy specimens, and clinical and survival data from records of 108 patients who were diagnosed between 2000 and 2010 at the Institute of Pathology University of Zagreb School of Medicine, of whom 98 had epithelioid MPM, six biphasic MPM, and four sarcomatoid MPM. Among epithelioid subtypes, 44 (44.9 %) were solid, 19 (19.4 %) tubulopapillary, 18 (18.4 %) acinar, six (6.1 %) adenomatoid, five (5.1 %) pleomorphic, four (4.1 %) trabecular, and two (2.0 %) micropapillary subtype. Interobserver reliability for histological diagnosis was found to be
κ
= 0.72 (
P
< 0.001). Median overall survival for epithelioid MPM was 10.5 months with an interquartile range (IQR) of 5.8–28.0 months but significantly shorter for the pleomorphic subtype (3 [IQR 3.0–8.0] months;
P
= 0.034), but not significantly different from biphasic (6.5 [IQR 3.5–15.3] months) and sarcomatoid mesothelioma (4.0 [IQR 1.3–6.8] months;
P
= 0.270). We found strong reproducibility of MPM subtyping with good interobserver agreement. Furthermore, our results indicate that pleomorphic subtype to be a predictor of poor prognosis and support classifying it with sarcomatoid or biphasic MPM, as patients with the pleomorphic, biphasic, or sarcomatoid subtype show similarly poor overall survival.</description><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesothelioma</subject><subject>Mesothelioma - mortality</subject><subject>Mesothelioma - pathology</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pleural Neoplasms - mortality</subject><subject>Pleural Neoplasms - pathology</subject><subject>Prognosis</subject><subject>Reproducibility of Results</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMFqGzEQhkVpqR23D9BLMeSSy6YaSSvtHoNpkxBDoLRnIe2ObBntylntHvz2kWsnhEBPYvi_-TV8hHwDeg2Uqh-JUsGqgoIoQEpR1B_IHARnBeNUfSRzWouykBzUjFyktKOUQQXyM5mxkueB1XPy8Bv3Q2ynxlsf_HhYRrfc-jTGEDe-MWGZJjse9r7fHJPOBL_pTT8u9wGnIccdpjhuMfjYmS_kkzMh4dfzuyB_f_38s7or1o-396ubddGUJYyFdSDAWqS8MQ7zBK41lpeUl9bRStnaGWxqVLU1KKRTbctYJVAKKiVXii_I1ak3X_40YRp151ODIZge45Q0SFZVqqrZEb18h-7iNPT5un8UKAmUZQpOVDPElAZ0ej_4zgwHDVQfTeuTaZ1N66NpXeed7-fmyXbYvm68qM0AOwEpR_0Ghzdf_7f1GUa8igA</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Brčić, Luka</creator><creator>Jakopović, Marko</creator><creator>Brčić, Iva</creator><creator>Klarić, Vlasta</creator><creator>Milošević, Milan</creator><creator>Šepac, Ana</creator><creator>Samaržija, Miroslav</creator><creator>Seiwerth, Sven</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>Reproducibility of histological subtyping of malignant pleural mesothelioma</title><author>Brčić, Luka ; Jakopović, Marko ; Brčić, Iva ; Klarić, Vlasta ; Milošević, Milan ; Šepac, Ana ; Samaržija, Miroslav ; Seiwerth, Sven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-bf141bbe03cafebf11fdab35035bf087b9faec9e79bae46f7dd2284e640663773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mesothelioma</topic><topic>Mesothelioma - 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Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brčić, Luka</au><au>Jakopović, Marko</au><au>Brčić, Iva</au><au>Klarić, Vlasta</au><au>Milošević, Milan</au><au>Šepac, Ana</au><au>Samaržija, Miroslav</au><au>Seiwerth, Sven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproducibility of histological subtyping of malignant pleural mesothelioma</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>465</volume><issue>6</issue><spage>679</spage><epage>685</epage><pages>679-685</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Malignant pleural mesothelioma (MPM) has a very poor prognosis. Although clinical stage is currently the only reliable prognostic factor, histologic subtyping reportedly also affects prognosis. Some studies propose reclassification of pleomorphic epithelioid as biphasic or sarcomatoid MPM. This study assessed prognostic significance and interobserver agreement in MPM subtyping of small biopsy specimens. We analyzed biopsy specimens, and clinical and survival data from records of 108 patients who were diagnosed between 2000 and 2010 at the Institute of Pathology University of Zagreb School of Medicine, of whom 98 had epithelioid MPM, six biphasic MPM, and four sarcomatoid MPM. Among epithelioid subtypes, 44 (44.9 %) were solid, 19 (19.4 %) tubulopapillary, 18 (18.4 %) acinar, six (6.1 %) adenomatoid, five (5.1 %) pleomorphic, four (4.1 %) trabecular, and two (2.0 %) micropapillary subtype. Interobserver reliability for histological diagnosis was found to be
κ
= 0.72 (
P
< 0.001). Median overall survival for epithelioid MPM was 10.5 months with an interquartile range (IQR) of 5.8–28.0 months but significantly shorter for the pleomorphic subtype (3 [IQR 3.0–8.0] months;
P
= 0.034), but not significantly different from biphasic (6.5 [IQR 3.5–15.3] months) and sarcomatoid mesothelioma (4.0 [IQR 1.3–6.8] months;
P
= 0.270). We found strong reproducibility of MPM subtyping with good interobserver agreement. Furthermore, our results indicate that pleomorphic subtype to be a predictor of poor prognosis and support classifying it with sarcomatoid or biphasic MPM, as patients with the pleomorphic, biphasic, or sarcomatoid subtype show similarly poor overall survival.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25300229</pmid><doi>10.1007/s00428-014-1664-9</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Female Humans Kaplan-Meier Estimate Male Medicine Medicine & Public Health Mesothelioma Mesothelioma - mortality Mesothelioma - pathology Middle Aged Observer Variation Original Article Pathology Pleural Neoplasms - mortality Pleural Neoplasms - pathology Prognosis Reproducibility of Results |
| title | Reproducibility of histological subtyping of malignant pleural mesothelioma |
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