Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

A combination of genome-wide exome and transcriptome analysis, mass spectrometry and computational structural modelling are used here to identify immunogenic neo-antigens in two mouse tumour cancer cell lines; mice vaccinated with predicted immunogenic peptides yielded therapeutically useful cytotox...

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Veröffentlicht in:	Nature (London) 2014-11, Vol.515 (7528), p.572-576
Hauptverfasser:	Yadav, Mahesh, Jhunjhunwala, Suchit, Phung, Qui T., Lupardus, Patrick, Tanguay, Joshua, Bumbaca, Stephanie, Franci, Christian, Cheung, Tommy K., Fritsche, Jens, Weinschenk, Toni, Modrusan, Zora, Mellman, Ira, Lill, Jennie R., Delamarre, Lélia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/1566/20 631/250/580/1884 Analysis Animals Antigenic determinants Cancer Vaccines - immunology CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Exome - genetics Exome sequencing Female Gene Expression Profiling Genetic aspects Health aspects Humanities and Social Sciences Immune response Immunity, Cellular - immunology Immunogenetic Phenomena - genetics Immunoprecipitation letter Mass Spectrometry Mice Mice, Inbred C57BL Models, Molecular multidisciplinary Mutation Neoplasms - genetics Neoplasms - immunology Peptides - genetics Protein Structure, Tertiary Rodents as pets Science T cells Tumors
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