Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial
Objective The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid for elderly people affected by xerostomia. Material and methods This research took the form of a double‐blind, randomized clinical trial. Forty‐one individuals (mean age: 78.7...
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| Veröffentlicht in: | Gerodontology 2014-12, Vol.31 (4), p.274-280 |
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| creator | Gómez-Moreno, Gerardo Cabrera-Ayala, Maribel Aguilar-Salvatierra, Antonio Guardia, Javier Ramírez-Fernández, María Piedad González-Jaranay, Maximino Calvo-Guirado, José Luis |
| description | Objective
The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid for elderly people affected by xerostomia.
Material and methods
This research took the form of a double‐blind, randomized clinical trial. Forty‐one individuals (mean age: 78.7 years) with xerostomia were divided into two groups: for the first ‘intervention group’ (21 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second ‘control group’ (20 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Xerostomia Inventory (XI) was used to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after spray application, were measured.
Results
XI scores decreased significantly (clinically meaningful) from 36.4 ± 7.3 points to 29.1 ± 7.1 (p |
| doi_str_mv | 10.1111/ger.12034 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1628878193</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1628878193</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4334-a6480e98b6e3713c04b3436f32f8b4c6811666e3eaeec4a05c10e4e9151aaf623</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxi1ERZfCgRdAviCBRFo7dpxsb6gs20qrIlH-SFysiTPZGpw42AlteBieFbfb9sZcRuP5zTcaf4S84OyQpzjaYjjkORPyEVnwUvIsF0X1mCxYKWTGlJL75GmMPxjLizIXT8h-LvKlFAVbkL-r3-AmGK3vqW_peIkU29YaMPNNDXT0Q6ocjRac3_rthDQOAWZqfD-C7W2_pR04aygY21D-itqeomswuJkO6AeH9MqOl_Qag4-j7ywcJ9nGT7XDrHa2b97SAH2TOn-woSa93C4cQ9r4jOy14CI-v8sH5MuH1eeT02zzcX128m6TGSnSjaBkxXBZ1QpFyYVhshZSqFbkbVVLoyrOlUo9BEQjgRWGM5S45AUHaFUuDsjrne4Q_K8J46g7Gw06Bz36KWqu8qoqK74UCX2zQ026JwZs9RBsB2HWnOkbO3SyQ9_akdiXd7JT3WHzQN7_fwKOdsCVdTj_X0mvV5_uJbPdhI0jXj9MQPipVSnKQn87X-uLr9_ley4u9Eb8AzdlpPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1628878193</pqid></control><display><type>article</type><title>Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Gómez-Moreno, Gerardo ; Cabrera-Ayala, Maribel ; Aguilar-Salvatierra, Antonio ; Guardia, Javier ; Ramírez-Fernández, María Piedad ; González-Jaranay, Maximino ; Calvo-Guirado, José Luis</creator><creatorcontrib>Gómez-Moreno, Gerardo ; Cabrera-Ayala, Maribel ; Aguilar-Salvatierra, Antonio ; Guardia, Javier ; Ramírez-Fernández, María Piedad ; González-Jaranay, Maximino ; Calvo-Guirado, José Luis</creatorcontrib><description>Objective
The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid for elderly people affected by xerostomia.
Material and methods
This research took the form of a double‐blind, randomized clinical trial. Forty‐one individuals (mean age: 78.7 years) with xerostomia were divided into two groups: for the first ‘intervention group’ (21 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second ‘control group’ (20 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Xerostomia Inventory (XI) was used to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after spray application, were measured.
Results
XI scores decreased significantly (clinically meaningful) from 36.4 ± 7.3 points to 29.1 ± 7.1 (p < 0.05) with an XI difference of 7.2 ± 6.1, after the combination among 1% malic acid with xylitol and fluoride application. After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (p < 0.05).
Conclusion
A topical sialogogue spray containing 1% malic acid improved xerostomia in an elderly population and increased unstimulated and stimulated salivary flows rates.</description><identifier>ISSN: 0734-0664</identifier><identifier>EISSN: 1741-2358</identifier><identifier>DOI: 10.1111/ger.12034</identifier><identifier>PMID: 23294350</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Aerosols ; Aged ; Aged, 80 and over ; Dentistry ; Double-Blind Method ; drug ; elderly ; Female ; Fluorides - administration & dosage ; Fluorides - therapeutic use ; Humans ; hyposialia ; Malates - administration & dosage ; Malates - therapeutic use ; Male ; malic acid ; Placebos ; Saliva - drug effects ; Saliva - secretion ; Saliva, Artificial - administration & dosage ; Saliva, Artificial - therapeutic use ; Secretory Rate - drug effects ; Treatment Outcome ; xerostomia ; Xerostomia - classification ; Xerostomia - drug therapy ; Xylitol - administration & dosage ; Xylitol - therapeutic use</subject><ispartof>Gerodontology, 2014-12, Vol.31 (4), p.274-280</ispartof><rights>2013 The Gerodontology Society and John Wiley & Sons A/S</rights><rights>2013 The Gerodontology Society and John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4334-a6480e98b6e3713c04b3436f32f8b4c6811666e3eaeec4a05c10e4e9151aaf623</citedby><cites>FETCH-LOGICAL-c4334-a6480e98b6e3713c04b3436f32f8b4c6811666e3eaeec4a05c10e4e9151aaf623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fger.12034$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fger.12034$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23294350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gómez-Moreno, Gerardo</creatorcontrib><creatorcontrib>Cabrera-Ayala, Maribel</creatorcontrib><creatorcontrib>Aguilar-Salvatierra, Antonio</creatorcontrib><creatorcontrib>Guardia, Javier</creatorcontrib><creatorcontrib>Ramírez-Fernández, María Piedad</creatorcontrib><creatorcontrib>González-Jaranay, Maximino</creatorcontrib><creatorcontrib>Calvo-Guirado, José Luis</creatorcontrib><title>Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial</title><title>Gerodontology</title><addtitle>Gerodontology</addtitle><description>Objective
The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid for elderly people affected by xerostomia.
Material and methods
This research took the form of a double‐blind, randomized clinical trial. Forty‐one individuals (mean age: 78.7 years) with xerostomia were divided into two groups: for the first ‘intervention group’ (21 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second ‘control group’ (20 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Xerostomia Inventory (XI) was used to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after spray application, were measured.
Results
XI scores decreased significantly (clinically meaningful) from 36.4 ± 7.3 points to 29.1 ± 7.1 (p < 0.05) with an XI difference of 7.2 ± 6.1, after the combination among 1% malic acid with xylitol and fluoride application. After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (p < 0.05).
Conclusion
A topical sialogogue spray containing 1% malic acid improved xerostomia in an elderly population and increased unstimulated and stimulated salivary flows rates.</description><subject>Administration, Oral</subject><subject>Aerosols</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Dentistry</subject><subject>Double-Blind Method</subject><subject>drug</subject><subject>elderly</subject><subject>Female</subject><subject>Fluorides - administration & dosage</subject><subject>Fluorides - therapeutic use</subject><subject>Humans</subject><subject>hyposialia</subject><subject>Malates - administration & dosage</subject><subject>Malates - therapeutic use</subject><subject>Male</subject><subject>malic acid</subject><subject>Placebos</subject><subject>Saliva - drug effects</subject><subject>Saliva - secretion</subject><subject>Saliva, Artificial - administration & dosage</subject><subject>Saliva, Artificial - therapeutic use</subject><subject>Secretory Rate - drug effects</subject><subject>Treatment Outcome</subject><subject>xerostomia</subject><subject>Xerostomia - classification</subject><subject>Xerostomia - drug therapy</subject><subject>Xylitol - administration & dosage</subject><subject>Xylitol - therapeutic use</subject><issn>0734-0664</issn><issn>1741-2358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQxi1ERZfCgRdAviCBRFo7dpxsb6gs20qrIlH-SFysiTPZGpw42AlteBieFbfb9sZcRuP5zTcaf4S84OyQpzjaYjjkORPyEVnwUvIsF0X1mCxYKWTGlJL75GmMPxjLizIXT8h-LvKlFAVbkL-r3-AmGK3vqW_peIkU29YaMPNNDXT0Q6ocjRac3_rthDQOAWZqfD-C7W2_pR04aygY21D-itqeomswuJkO6AeH9MqOl_Qag4-j7ywcJ9nGT7XDrHa2b97SAH2TOn-woSa93C4cQ9r4jOy14CI-v8sH5MuH1eeT02zzcX128m6TGSnSjaBkxXBZ1QpFyYVhshZSqFbkbVVLoyrOlUo9BEQjgRWGM5S45AUHaFUuDsjrne4Q_K8J46g7Gw06Bz36KWqu8qoqK74UCX2zQ026JwZs9RBsB2HWnOkbO3SyQ9_akdiXd7JT3WHzQN7_fwKOdsCVdTj_X0mvV5_uJbPdhI0jXj9MQPipVSnKQn87X-uLr9_ley4u9Eb8AzdlpPw</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Gómez-Moreno, Gerardo</creator><creator>Cabrera-Ayala, Maribel</creator><creator>Aguilar-Salvatierra, Antonio</creator><creator>Guardia, Javier</creator><creator>Ramírez-Fernández, María Piedad</creator><creator>González-Jaranay, Maximino</creator><creator>Calvo-Guirado, José Luis</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201412</creationdate><title>Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial</title><author>Gómez-Moreno, Gerardo ; Cabrera-Ayala, Maribel ; Aguilar-Salvatierra, Antonio ; Guardia, Javier ; Ramírez-Fernández, María Piedad ; González-Jaranay, Maximino ; Calvo-Guirado, José Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4334-a6480e98b6e3713c04b3436f32f8b4c6811666e3eaeec4a05c10e4e9151aaf623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Oral</topic><topic>Aerosols</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Dentistry</topic><topic>Double-Blind Method</topic><topic>drug</topic><topic>elderly</topic><topic>Female</topic><topic>Fluorides - administration & dosage</topic><topic>Fluorides - therapeutic use</topic><topic>Humans</topic><topic>hyposialia</topic><topic>Malates - administration & dosage</topic><topic>Malates - therapeutic use</topic><topic>Male</topic><topic>malic acid</topic><topic>Placebos</topic><topic>Saliva - drug effects</topic><topic>Saliva - secretion</topic><topic>Saliva, Artificial - administration & dosage</topic><topic>Saliva, Artificial - therapeutic use</topic><topic>Secretory Rate - drug effects</topic><topic>Treatment Outcome</topic><topic>xerostomia</topic><topic>Xerostomia - classification</topic><topic>Xerostomia - drug therapy</topic><topic>Xylitol - administration & dosage</topic><topic>Xylitol - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gómez-Moreno, Gerardo</creatorcontrib><creatorcontrib>Cabrera-Ayala, Maribel</creatorcontrib><creatorcontrib>Aguilar-Salvatierra, Antonio</creatorcontrib><creatorcontrib>Guardia, Javier</creatorcontrib><creatorcontrib>Ramírez-Fernández, María Piedad</creatorcontrib><creatorcontrib>González-Jaranay, Maximino</creatorcontrib><creatorcontrib>Calvo-Guirado, José Luis</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gerodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez-Moreno, Gerardo</au><au>Cabrera-Ayala, Maribel</au><au>Aguilar-Salvatierra, Antonio</au><au>Guardia, Javier</au><au>Ramírez-Fernández, María Piedad</au><au>González-Jaranay, Maximino</au><au>Calvo-Guirado, José Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial</atitle><jtitle>Gerodontology</jtitle><addtitle>Gerodontology</addtitle><date>2014-12</date><risdate>2014</risdate><volume>31</volume><issue>4</issue><spage>274</spage><epage>280</epage><pages>274-280</pages><issn>0734-0664</issn><eissn>1741-2358</eissn><abstract>Objective
The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid for elderly people affected by xerostomia.
Material and methods
This research took the form of a double‐blind, randomized clinical trial. Forty‐one individuals (mean age: 78.7 years) with xerostomia were divided into two groups: for the first ‘intervention group’ (21 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second ‘control group’ (20 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Xerostomia Inventory (XI) was used to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after spray application, were measured.
Results
XI scores decreased significantly (clinically meaningful) from 36.4 ± 7.3 points to 29.1 ± 7.1 (p < 0.05) with an XI difference of 7.2 ± 6.1, after the combination among 1% malic acid with xylitol and fluoride application. After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (p < 0.05).
Conclusion
A topical sialogogue spray containing 1% malic acid improved xerostomia in an elderly population and increased unstimulated and stimulated salivary flows rates.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23294350</pmid><doi>10.1111/ger.12034</doi><tpages>7</tpages></addata></record> |
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| ispartof | Gerodontology, 2014-12, Vol.31 (4), p.274-280 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Administration, Oral Aerosols Aged Aged, 80 and over Dentistry Double-Blind Method drug elderly Female Fluorides - administration & dosage Fluorides - therapeutic use Humans hyposialia Malates - administration & dosage Malates - therapeutic use Male malic acid Placebos Saliva - drug effects Saliva - secretion Saliva, Artificial - administration & dosage Saliva, Artificial - therapeutic use Secretory Rate - drug effects Treatment Outcome xerostomia Xerostomia - classification Xerostomia - drug therapy Xylitol - administration & dosage Xylitol - therapeutic use |
| title | Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial |
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