Issues in Setting Health-Based Cleanup Levels for Arsenic in Soil
Health risk assessments often do not take into account the unique aspects of evaluating exposures to arsenic in soil. For example, risks from ingestion of arsenic in soil are often based on toxicity factors derived from studies of arsenic (soluble arsenate or arsenite) in drinking water. However, th...
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| Veröffentlicht in: | Regulatory toxicology and pharmacology 1997-10, Vol.26 (2), p.219-229 |
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| container_title | Regulatory toxicology and pharmacology |
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| creator | Valberg, P.A. Beck, B.D. Bowers, T.S. Keating, J.L. Bergstrom, P.D. Boardman, P.D. |
| description | Health risk assessments often do not take into account the unique aspects of evaluating exposures to arsenic in soil. For example, risks from ingestion of arsenic in soil are often based on toxicity factors derived from studies of arsenic (soluble arsenate or arsenite) in drinking water. However, the toxicity of arsenic in drinking water cannot be directly extrapolated to toxicity of soil arsenic because of differences in chemical form, bioavailability, and excretion kinetics. Because of the differences between soil arsenic and water arsenic, we conclude that risks from arsenic in soil are lower than what would be calculated using default toxicity values for arsenic in drinking water. Site-specific risk assessments for arsenic in soil can be improved by characterizing the form of arsenic in soil, by conducting animal feeding orin vitrobioavailability studies using site soils, and by conducting studies to evaluate the relationship between urinary arsenic and soil arsenic levels. Such data could be used to more accurately measure the contribution that soil arsenic makes to total intake of arsenic. Available data suggest that arsenic usually makes a small contribution to this total. |
| doi_str_mv | 10.1006/rtph.1997.1148 |
| format | Article |
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For example, risks from ingestion of arsenic in soil are often based on toxicity factors derived from studies of arsenic (soluble arsenate or arsenite) in drinking water. However, the toxicity of arsenic in drinking water cannot be directly extrapolated to toxicity of soil arsenic because of differences in chemical form, bioavailability, and excretion kinetics. Because of the differences between soil arsenic and water arsenic, we conclude that risks from arsenic in soil are lower than what would be calculated using default toxicity values for arsenic in drinking water. Site-specific risk assessments for arsenic in soil can be improved by characterizing the form of arsenic in soil, by conducting animal feeding orin vitrobioavailability studies using site soils, and by conducting studies to evaluate the relationship between urinary arsenic and soil arsenic levels. Such data could be used to more accurately measure the contribution that soil arsenic makes to total intake of arsenic. Available data suggest that arsenic usually makes a small contribution to this total.</description><identifier>ISSN: 0273-2300</identifier><identifier>EISSN: 1096-0295</identifier><identifier>DOI: 10.1006/rtph.1997.1148</identifier><identifier>PMID: 9356285</identifier><identifier>CODEN: RTOPDW</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Animals ; Arsenic - analysis ; Arsenic - pharmacokinetics ; Arsenic - urine ; Arsenicals - analysis ; Arsenicals - chemistry ; Biological and medical sciences ; Biological Availability ; Carcinogens - analysis ; Environmental Exposure - statistics & numerical data ; Environmental pollutants toxicology ; Food Contamination ; Fresh Water - analysis ; General aspects ; Humans ; Medical sciences ; Public Health - standards ; Risk Assessment ; Soil Pollutants - analysis ; Soil Pollutants - standards ; Soil Pollutants - urine ; Solubility ; Toxicology ; United States ; Water Pollutants, Chemical - analysis</subject><ispartof>Regulatory toxicology and pharmacology, 1997-10, Vol.26 (2), p.219-229</ispartof><rights>1997 Academic Press</rights><rights>1998 INIST-CNRS</rights><rights>Copyright 1997 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-c4164fc80f6a207003d5631e85fe008c2c9edfddc0fd61435ca9421361093afa3</citedby><cites>FETCH-LOGICAL-c399t-c4164fc80f6a207003d5631e85fe008c2c9edfddc0fd61435ca9421361093afa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S027323009791148X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2078081$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9356285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valberg, P.A.</creatorcontrib><creatorcontrib>Beck, B.D.</creatorcontrib><creatorcontrib>Bowers, T.S.</creatorcontrib><creatorcontrib>Keating, J.L.</creatorcontrib><creatorcontrib>Bergstrom, P.D.</creatorcontrib><creatorcontrib>Boardman, P.D.</creatorcontrib><title>Issues in Setting Health-Based Cleanup Levels for Arsenic in Soil</title><title>Regulatory toxicology and pharmacology</title><addtitle>Regul Toxicol Pharmacol</addtitle><description>Health risk assessments often do not take into account the unique aspects of evaluating exposures to arsenic in soil. For example, risks from ingestion of arsenic in soil are often based on toxicity factors derived from studies of arsenic (soluble arsenate or arsenite) in drinking water. However, the toxicity of arsenic in drinking water cannot be directly extrapolated to toxicity of soil arsenic because of differences in chemical form, bioavailability, and excretion kinetics. Because of the differences between soil arsenic and water arsenic, we conclude that risks from arsenic in soil are lower than what would be calculated using default toxicity values for arsenic in drinking water. Site-specific risk assessments for arsenic in soil can be improved by characterizing the form of arsenic in soil, by conducting animal feeding orin vitrobioavailability studies using site soils, and by conducting studies to evaluate the relationship between urinary arsenic and soil arsenic levels. Such data could be used to more accurately measure the contribution that soil arsenic makes to total intake of arsenic. Available data suggest that arsenic usually makes a small contribution to this total.</description><subject>Adult</subject><subject>Animals</subject><subject>Arsenic - analysis</subject><subject>Arsenic - pharmacokinetics</subject><subject>Arsenic - urine</subject><subject>Arsenicals - analysis</subject><subject>Arsenicals - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Carcinogens - analysis</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Environmental pollutants toxicology</subject><subject>Food Contamination</subject><subject>Fresh Water - analysis</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Public Health - standards</subject><subject>Risk Assessment</subject><subject>Soil Pollutants - analysis</subject><subject>Soil Pollutants - standards</subject><subject>Soil Pollutants - urine</subject><subject>Solubility</subject><subject>Toxicology</subject><subject>United States</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>0273-2300</issn><issn>1096-0295</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDFPwzAQRi0EglJY2ZAyILaUs5249lgqoJUqMQCzZewzGKVJsVMk_j0OrdiYbrj3ne57hFxQmFAAcRP7zfuEKjWdUFrJAzKioEQJTNWHZARsykvGAU7IaUofAMCknB6TY8VrwWQ9IrNlSltMRWiLJ-z70L4VCzRN_17emoSumDdo2u2mWOEXNqnwXSxmMWEb7G-kC80ZOfKmSXi-n2Pycn_3PF-Uq8eH5Xy2Ki1Xqi9tRUXlrQQvDIMpAHe14BRl7RFAWmYVOu-cBe8ErXhtjaoY5SL34cYbPibXu7ub2H3ml3u9Dsli05gWu23SNBeSTKgMTnagjV1KEb3exLA28VtT0IMzPTjTgzM9OMuBy_3l7esa3R--l5T3V_u9SdY0PprWhvSH5TYSJM2Y3GFZFH4FjDrZgK1FFyLaXrsu_PfBD8VUhnY</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Valberg, P.A.</creator><creator>Beck, B.D.</creator><creator>Bowers, T.S.</creator><creator>Keating, J.L.</creator><creator>Bergstrom, P.D.</creator><creator>Boardman, P.D.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19971001</creationdate><title>Issues in Setting Health-Based Cleanup Levels for Arsenic in Soil</title><author>Valberg, P.A. ; Beck, B.D. ; Bowers, T.S. ; Keating, J.L. ; Bergstrom, P.D. ; Boardman, P.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-c4164fc80f6a207003d5631e85fe008c2c9edfddc0fd61435ca9421361093afa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Arsenic - analysis</topic><topic>Arsenic - pharmacokinetics</topic><topic>Arsenic - urine</topic><topic>Arsenicals - analysis</topic><topic>Arsenicals - chemistry</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Carcinogens - analysis</topic><topic>Environmental Exposure - statistics & numerical data</topic><topic>Environmental pollutants toxicology</topic><topic>Food Contamination</topic><topic>Fresh Water - analysis</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Public Health - standards</topic><topic>Risk Assessment</topic><topic>Soil Pollutants - analysis</topic><topic>Soil Pollutants - standards</topic><topic>Soil Pollutants - urine</topic><topic>Solubility</topic><topic>Toxicology</topic><topic>United States</topic><topic>Water Pollutants, Chemical - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valberg, P.A.</creatorcontrib><creatorcontrib>Beck, B.D.</creatorcontrib><creatorcontrib>Bowers, T.S.</creatorcontrib><creatorcontrib>Keating, J.L.</creatorcontrib><creatorcontrib>Bergstrom, P.D.</creatorcontrib><creatorcontrib>Boardman, P.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Regulatory toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valberg, P.A.</au><au>Beck, B.D.</au><au>Bowers, T.S.</au><au>Keating, J.L.</au><au>Bergstrom, P.D.</au><au>Boardman, P.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Issues in Setting Health-Based Cleanup Levels for Arsenic in Soil</atitle><jtitle>Regulatory toxicology and pharmacology</jtitle><addtitle>Regul Toxicol Pharmacol</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>26</volume><issue>2</issue><spage>219</spage><epage>229</epage><pages>219-229</pages><issn>0273-2300</issn><eissn>1096-0295</eissn><coden>RTOPDW</coden><abstract>Health risk assessments often do not take into account the unique aspects of evaluating exposures to arsenic in soil. For example, risks from ingestion of arsenic in soil are often based on toxicity factors derived from studies of arsenic (soluble arsenate or arsenite) in drinking water. However, the toxicity of arsenic in drinking water cannot be directly extrapolated to toxicity of soil arsenic because of differences in chemical form, bioavailability, and excretion kinetics. Because of the differences between soil arsenic and water arsenic, we conclude that risks from arsenic in soil are lower than what would be calculated using default toxicity values for arsenic in drinking water. Site-specific risk assessments for arsenic in soil can be improved by characterizing the form of arsenic in soil, by conducting animal feeding orin vitrobioavailability studies using site soils, and by conducting studies to evaluate the relationship between urinary arsenic and soil arsenic levels. Such data could be used to more accurately measure the contribution that soil arsenic makes to total intake of arsenic. Available data suggest that arsenic usually makes a small contribution to this total.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>9356285</pmid><doi>10.1006/rtph.1997.1148</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Animals Arsenic - analysis Arsenic - pharmacokinetics Arsenic - urine Arsenicals - analysis Arsenicals - chemistry Biological and medical sciences Biological Availability Carcinogens - analysis Environmental Exposure - statistics & numerical data Environmental pollutants toxicology Food Contamination Fresh Water - analysis General aspects Humans Medical sciences Public Health - standards Risk Assessment Soil Pollutants - analysis Soil Pollutants - standards Soil Pollutants - urine Solubility Toxicology United States Water Pollutants, Chemical - analysis |
| title | Issues in Setting Health-Based Cleanup Levels for Arsenic in Soil |
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