Vaccination of Cats for Feline Rhinotracheitis Results in a Quantitative Reduction of Virulent Feline Herpesvirus-1 Latency Load after Challenge
We recently described the construction of a feline herpesvirus-1 (FHV-1) recombinant vaccine strain, FHVβ-galgIgEΔ, containing a deletion in both the gI and the gE genes. We also reported comparative tests of its safety and efficacy in cats. These cats were unvaccinated or subcutaneously vaccinated...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1997-02, Vol.228 (2), p.379-382 |
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| creator | Sussman, Michael D Maes, Roger K Kruger, John M |
| description | We recently described the construction of a feline herpesvirus-1 (FHV-1) recombinant vaccine strain, FHVβ-galgIgEΔ, containing a deletion in both the gI and the gE genes. We also reported comparative tests of its safety and efficacy in cats. These cats were unvaccinated or subcutaneously vaccinated with FHVβ-galgIgEΔ, its isotypic parent strain (FHV-1SA), or a commercial FHV-1 vaccine strain (FHV-1CV) and subsequently challenged with a virulent field strain of FHV-1. Here we report the determination of FHV-1 field virus latency load after challenge in the same experimental animals. FHV-1 specific quantitative PCR was carried out on feline genomic DNA isolated from trigeminal ganglia, olfactory bulbs, and brain stems. We have determined that a reduction in field virus latency load in cats vaccinated subcutaneously with wild-type FHV-1 strains prior to challenge is dependent upon glycoproteins gI and gE deleted in FHVβ-galgIgEΔ. |
| doi_str_mv | 10.1006/viro.1996.8393 |
| format | Article |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Cat Diseases - prevention & control Cat Diseases - virology Cats CHAT DNA, Viral - analysis GATO Genome, Viral Herpesviridae Infections - prevention & control Herpesviridae Infections - veterinary Herpesviridae Infections - virology HERPETOVIRIDAE RHINOTRACHEITE RINOTRAQUEITIS Trigeminal Ganglion - virology VACCINATION VACUNACION Viral Envelope Proteins - genetics Viral Load Viral Vaccines - immunology Virulence Virus Latency |
| title | Vaccination of Cats for Feline Rhinotracheitis Results in a Quantitative Reduction of Virulent Feline Herpesvirus-1 Latency Load after Challenge |
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