The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons
The highly homologous small nuclear ribonucleoprotein-associated proteins of the Sm group, human N and B/B', are derived from distinct, but similar genes. While the almost identical structural organization of the genes for N and B/B' suggests that they emerged from a common ancestral gene...
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| Veröffentlicht in: | The Journal of biological chemistry 1992-04, Vol.267 (12), p.8521-8529 |
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| container_title | The Journal of biological chemistry |
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| creator | SCHMAUSS, C BRINES, ML LERNER, MR |
| description | The highly homologous small nuclear ribonucleoprotein-associated proteins of the Sm group, human N and B/B', are derived from
distinct, but similar genes. While the almost identical structural organization of the genes for N and B/B' suggests that
they emerged from a common ancestral gene via a duplication event, they now reside on different chromosomes. In contrast to
B (which is expressed in all tissues examined) and B' (which is widely expressed with the notable exception of the brain),
results from in situ hybridization experiments showed that N is found predominantly in central neurons. Analysis of the transcriptional
activity of the 5'-flanking sequences of the human N-encoded gene suggests that the cell-specific expression of N is achieved
by selective repression of transcription by distal 5'-flanking sequences. |
| doi_str_mv | 10.1016/S0021-9258(18)42475-1 |
| format | Article |
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distinct, but similar genes. While the almost identical structural organization of the genes for N and B/B' suggests that
they emerged from a common ancestral gene via a duplication event, they now reside on different chromosomes. In contrast to
B (which is expressed in all tissues examined) and B' (which is widely expressed with the notable exception of the brain),
results from in situ hybridization experiments showed that N is found predominantly in central neurons. Analysis of the transcriptional
activity of the 5'-flanking sequences of the human N-encoded gene suggests that the cell-specific expression of N is achieved
by selective repression of transcription by distal 5'-flanking sequences.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(18)42475-1</identifier><identifier>PMID: 1533223</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>BETHESDA: American Society for Biochemistry and Molecular Biology</publisher><subject>Animals ; Autoantigens - genetics ; Base Sequence ; Biochemistry & Molecular Biology ; Biological and medical sciences ; Blotting, Southern ; Chromosome Mapping ; containing ; DNA - genetics ; Exons ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; HeLa Cells ; Humans ; Hybrid Cells ; Life Sciences & Biomedicine ; man ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; neurons ; Neurons - metabolism ; Nucleic Acid Hybridization ; Plasmids ; Polymerase Chain Reaction ; Rats ; ribonucleoprotein N ; Ribonucleoproteins - genetics ; Ribonucleoproteins, Small Nuclear ; RNA, Messenger - genetics ; Science & Technology ; snRNA ; snRNP Core Proteins ; Transcription, Genetic ; Transfection</subject><ispartof>The Journal of biological chemistry, 1992-04, Vol.267 (12), p.8521-8529</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>52</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HQ18500086</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c439t-b780f2cce661688dbe72f32963512b35ce5ec9377ad8556e5d2d4dc870515f4d3</citedby><cites>FETCH-LOGICAL-c439t-b780f2cce661688dbe72f32963512b35ce5ec9377ad8556e5d2d4dc870515f4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27199,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5290270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1533223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHMAUSS, C</creatorcontrib><creatorcontrib>BRINES, ML</creatorcontrib><creatorcontrib>LERNER, MR</creatorcontrib><title>The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons</title><title>The Journal of biological chemistry</title><addtitle>J BIOL CHEM</addtitle><addtitle>J Biol Chem</addtitle><description>The highly homologous small nuclear ribonucleoprotein-associated proteins of the Sm group, human N and B/B', are derived from
distinct, but similar genes. While the almost identical structural organization of the genes for N and B/B' suggests that
they emerged from a common ancestral gene via a duplication event, they now reside on different chromosomes. In contrast to
B (which is expressed in all tissues examined) and B' (which is widely expressed with the notable exception of the brain),
results from in situ hybridization experiments showed that N is found predominantly in central neurons. Analysis of the transcriptional
activity of the 5'-flanking sequences of the human N-encoded gene suggests that the cell-specific expression of N is achieved
by selective repression of transcription by distal 5'-flanking sequences.</description><subject>Animals</subject><subject>Autoantigens - genetics</subject><subject>Base Sequence</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>Chromosome Mapping</subject><subject>containing</subject><subject>DNA - genetics</subject><subject>Exons</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hybrid Cells</subject><subject>Life Sciences & Biomedicine</subject><subject>man</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>neurons</subject><subject>Neurons - metabolism</subject><subject>Nucleic Acid Hybridization</subject><subject>Plasmids</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>ribonucleoprotein N</subject><subject>Ribonucleoproteins - genetics</subject><subject>Ribonucleoproteins, Small Nuclear</subject><subject>RNA, Messenger - genetics</subject><subject>Science & Technology</subject><subject>snRNA</subject><subject>snRNP Core Proteins</subject><subject>Transcription, Genetic</subject><subject>Transfection</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkV1vFCEUhonR1Lr6E5qQaBqNGeXAMDCXzUatSaMx1sQ7wjBndjGzsIUZq_9e9iPrpXIDOTwvHHgIuQD2Bhg0b78yxqFqudQvQb-qea1kBQ_IOTAtKiHh-0NyfkIekyc5_2Bl1C2ckTOQQnAuzsnd7RrpCgNSDC72PqzoVCp5Y8eRhtmNaBNNvov7ddymOKEPlc05Om8n7OmxRD9Rnyn-2ibMuZTtRNd-taYj_sQx0wIEnFMM-Sl5NNgx47PjvCDf3r-7XV5XN58_fFxe3VSuFu1UdUqzgTuHTQON1n2Hig-Ct015Gu-EdCjRtUIp22spG5Q97-veacUkyKHuxYJcHs4tDd7NmCez8dnhONqAcc5G8ZaBEuKfIDRcN0LxAsoD6FLMOeFgtslvbPptgJmdE7N3YnYfbkCbvRMDJXdxvGDuNtj_TR0klP0Xx32bnR2HZIPz-YTJ0ihXrGCvD9g9dnHIzhdjeKKuoG359RfQskgu_S6I_n966Sc7-RiWcQ5TiT4_RHcC731C0_no1rgxvFEGuNGSg_gDnF3CCg</recordid><startdate>19920425</startdate><enddate>19920425</enddate><creator>SCHMAUSS, C</creator><creator>BRINES, ML</creator><creator>LERNER, MR</creator><general>American Society for Biochemistry and Molecular Biology</general><general>Amer Soc Biochemistry Molecular Biology Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19920425</creationdate><title>The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons</title><author>SCHMAUSS, C ; BRINES, ML ; LERNER, MR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-b780f2cce661688dbe72f32963512b35ce5ec9377ad8556e5d2d4dc870515f4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Autoantigens - genetics</topic><topic>Base Sequence</topic><topic>Biochemistry & Molecular Biology</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>Chromosome Mapping</topic><topic>containing</topic><topic>DNA - genetics</topic><topic>Exons</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hybrid Cells</topic><topic>Life Sciences & Biomedicine</topic><topic>man</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>neurons</topic><topic>Neurons - metabolism</topic><topic>Nucleic Acid Hybridization</topic><topic>Plasmids</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>ribonucleoprotein N</topic><topic>Ribonucleoproteins - genetics</topic><topic>Ribonucleoproteins, Small Nuclear</topic><topic>RNA, Messenger - genetics</topic><topic>Science & Technology</topic><topic>snRNA</topic><topic>snRNP Core Proteins</topic><topic>Transcription, Genetic</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHMAUSS, C</creatorcontrib><creatorcontrib>BRINES, ML</creatorcontrib><creatorcontrib>LERNER, MR</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHMAUSS, C</au><au>BRINES, ML</au><au>LERNER, MR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons</atitle><jtitle>The Journal of biological chemistry</jtitle><stitle>J BIOL CHEM</stitle><addtitle>J Biol Chem</addtitle><date>1992-04-25</date><risdate>1992</risdate><volume>267</volume><issue>12</issue><spage>8521</spage><epage>8529</epage><pages>8521-8529</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>The highly homologous small nuclear ribonucleoprotein-associated proteins of the Sm group, human N and B/B', are derived from
distinct, but similar genes. While the almost identical structural organization of the genes for N and B/B' suggests that
they emerged from a common ancestral gene via a duplication event, they now reside on different chromosomes. In contrast to
B (which is expressed in all tissues examined) and B' (which is widely expressed with the notable exception of the brain),
results from in situ hybridization experiments showed that N is found predominantly in central neurons. Analysis of the transcriptional
activity of the 5'-flanking sequences of the human N-encoded gene suggests that the cell-specific expression of N is achieved
by selective repression of transcription by distal 5'-flanking sequences.</abstract><cop>BETHESDA</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>1533223</pmid><doi>10.1016/S0021-9258(18)42475-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of biological chemistry, 1992-04, Vol.267 (12), p.8521-8529 |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Autoantigens - genetics Base Sequence Biochemistry & Molecular Biology Biological and medical sciences Blotting, Southern Chromosome Mapping containing DNA - genetics Exons Fundamental and applied biological sciences. Psychology Gene Expression HeLa Cells Humans Hybrid Cells Life Sciences & Biomedicine man Molecular and cellular biology Molecular genetics Molecular Sequence Data neurons Neurons - metabolism Nucleic Acid Hybridization Plasmids Polymerase Chain Reaction Rats ribonucleoprotein N Ribonucleoproteins - genetics Ribonucleoproteins, Small Nuclear RNA, Messenger - genetics Science & Technology snRNA snRNP Core Proteins Transcription, Genetic Transfection |
| title | The gene encoding the small nuclear ribonucleoprotein-associated protein N is expressed at high levels in neurons |
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