Use of the harmonic mean to the determination of dissociation constants of stereoisomeric mixtures of biologically active compounds

Abstract Herein we introduce the derivation of a mathematical expression to evaluate the dissociation constant of a mixture of stereoisomers in equal amounts (KdMIX), when the corresponding dissociation constants (Kd) or medium response (MR50) of the pure stereoisomers are known; the final equation...

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