Effect of lindane upon the β-adrenergic stimulation of cyclic AMP accumulation in rat renal cortical tubules caused by alterations in membrane fluidity

The influence of lindane (gamma-hexachlorocyclohexane) on fludity and lipid composition in rat renal cortical tubules has been investigated. Lindane increased membrane fluidity as measured by a fluorescence polarization technique using the probe diphenylhexatriene. This effect was dose-dependent and...

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Veröffentlicht in:	Life sciences (1973) 1991, Vol.49 (16), p.1141-1154
Hauptverfasser:	López-Aparicio, Pilar, Recio, María N., Prieto, Juan C., Carmena, María J., Pérez-Albarsanz, Miguel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - metabolism Animals beta -adrenergic Biological and medical sciences Chromatography, Thin Layer Cyclic AMP - metabolism effects on Fluorescence Polarization Hexachlorocyclohexane - pharmacology In Vitro Techniques Isoproterenol - pharmacology kidney Kidney Cortex - drug effects Kidney Cortex - metabolism Kidney Tubules - drug effects Kidney Tubules - metabolism lindane Male Medical sciences membrane fluidity Membrane Fluidity - drug effects Membrane Lipids - metabolism Pesticides, fertilizers and other agrochemicals toxicology Phospholipids - metabolism Rats Rats, Inbred Strains receptors Receptors, Adrenergic, beta - physiology Toxicology
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