Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7

We report the isolation of a novel mouse voltage-gated Shaker-related K+ channel gene, Kv1.7 (Kcna7/KCNA7). Unlike other known Kv1 family genes that have intronless coding regions, the protein-coding region of Kv1.7 is interrupted by a 1.9-kilobase pair intron. The Kv1.7 gene and the related Kv3.3 (...

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Veröffentlicht in:	The Journal of biological chemistry 1998-03, Vol.273 (10), p.5851-5857
Hauptverfasser:	Kalman, K, Nguyen, A, Tseng-Crank, J, Dukes, I D, Chandy, G, Hustad, C M, Copeland, N G, Jenkins, N A, Mohrenweiser, H, Brandriff, B, Cahalan, M, Gutman, G A, Chandy, K G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Chromosome Mapping Chromosomes Cloning, Molecular Electrophysiology Humans In Situ Hybridization Ion Channel Gating - physiology Islets of Langerhans - cytology Islets of Langerhans - physiology Mice Mice, Inbred Strains Molecular Sequence Data Neurotoxins - pharmacology Phylogeny Potassium Channels - chemistry Potassium Channels - genetics Sequence Analysis, DNA Shaker Superfamily of Potassium Channels
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