Thiol-Mediated Regulation of ICAM-1 Expression in Endotoxin-Induced Acute Lung Injury

The intracellular redox state regulates several aspects of cell function, suggesting that strategies directed toward altering the cellular redox state may modulate cell activation in inflammatory states. As the most abundant intracellular thiol, glutathione plays a critical role as an intracellular...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-03, Vol.160 (6), p.2959-2966
Hauptverfasser:	Nathens, Avery B, Bitar, Richard, Watson, Ronald W.G, Issekutz, Thomas B, Marshall, John C, Dackiw, Alan P.B, Rotstein, Ori D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Gene Expression Regulation Glutathione - physiology Humans Intercellular Adhesion Molecule-1 - analysis Intercellular Adhesion Molecule-1 - genetics Lipopolysaccharides - toxicity Male Maleates - pharmacology Mice Neutrophils - physiology Oxidation-Reduction Rabbits Rats Rats, Sprague-Dawley Respiratory Distress Syndrome, Adult - metabolism RNA, Messenger - analysis Sulfhydryl Compounds - physiology Tumor Necrosis Factor-alpha - genetics
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