A Cyclic KLVFF-Derived Peptide Aggregation Inhibitor Induces the Formation of Less-Toxic Off-Pathway Amyloid-β Oligomers

Inhibition of amyloid‐β (Aβ) aggregation could be a target of drug development for the treatment of currently incurable Alzheimer's disease. We previously reported that a head‐to‐tail cyclic peptide of KLVFF (cyclic‐KLVFF), a pentapeptide fragment corresponding to the Aβ16–20 region (which play...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2014-11, Vol.15 (17), p.2577-2583
Hauptverfasser:	Arai, Tadamasa, Sasaki, Daisuke, Araya, Takushi, Sato, Takeshi, Sohma, Youhei, Kanai, Motomu
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation Alzheimer's disease Amino Acid Sequence amyloid beta-peptides Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - toxicity Animals Cell Survival - drug effects cyclic peptides Humans inhibitors Molecular Structure PC12 Cells Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Protein Aggregates - drug effects Protein Aggregation, Pathological - drug therapy Protein Aggregation, Pathological - metabolism Rats
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