Efficacy of growth factor in promoting early osseointegration
A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six fem...
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| Veröffentlicht in: | The Journal of oral implantology 2014-10, Vol.40 (5), p.543-548 |
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| creator | Al-Hezaimi, Khalid Nevins, Myron Kim, Soo-Woo Fateh, Ardavan Kim, David M |
| description | A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC. |
| doi_str_mv | 10.1563/aaid-joi-D-13-00304 |
| format | Article |
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Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.</description><identifier>ISSN: 0160-6972</identifier><identifier>EISSN: 1548-1336</identifier><identifier>DOI: 10.1563/aaid-joi-D-13-00304</identifier><identifier>PMID: 24946082</identifier><language>eng</language><publisher>United States: Allen Press Inc</publisher><subject>Angiogenesis Inducing Agents - therapeutic use ; Animals ; Bone density ; Coated Materials, Biocompatible - therapeutic use ; Colleges & universities ; Dental Implants ; Dental Prosthesis Design ; Dentistry ; Dogs ; Feasibility Studies ; Female ; Humans ; Hydroxyapatite ; Mandible - diagnostic imaging ; Mandible - drug effects ; Mandible - pathology ; Osseointegration - drug effects ; Osteogenesis - drug effects ; Postoperative period ; Proto-Oncogene Proteins c-sis - therapeutic use ; Radiography, Bitewing ; Random Allocation ; Recombinant Proteins ; Software ; Surface Properties ; Time Factors ; Viscosity ; Wound Healing - drug effects</subject><ispartof>The Journal of oral implantology, 2014-10, Vol.40 (5), p.543-548</ispartof><rights>Copyright Allen Press Publishing Services 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-13cd724412143851707e000f245a3c05156ca7490d15795093b8e61818201eb53</citedby><cites>FETCH-LOGICAL-c527t-13cd724412143851707e000f245a3c05156ca7490d15795093b8e61818201eb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24946082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Hezaimi, Khalid</creatorcontrib><creatorcontrib>Nevins, Myron</creatorcontrib><creatorcontrib>Kim, Soo-Woo</creatorcontrib><creatorcontrib>Fateh, Ardavan</creatorcontrib><creatorcontrib>Kim, David M</creatorcontrib><title>Efficacy of growth factor in promoting early osseointegration</title><title>The Journal of oral implantology</title><addtitle>J Oral Implantol</addtitle><description>A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.</description><subject>Angiogenesis Inducing Agents - therapeutic use</subject><subject>Animals</subject><subject>Bone density</subject><subject>Coated Materials, Biocompatible - therapeutic use</subject><subject>Colleges & universities</subject><subject>Dental Implants</subject><subject>Dental Prosthesis Design</subject><subject>Dentistry</subject><subject>Dogs</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Mandible - diagnostic imaging</subject><subject>Mandible - drug effects</subject><subject>Mandible - pathology</subject><subject>Osseointegration - drug effects</subject><subject>Osteogenesis - drug effects</subject><subject>Postoperative period</subject><subject>Proto-Oncogene Proteins c-sis - therapeutic use</subject><subject>Radiography, Bitewing</subject><subject>Random Allocation</subject><subject>Recombinant Proteins</subject><subject>Software</subject><subject>Surface Properties</subject><subject>Time Factors</subject><subject>Viscosity</subject><subject>Wound Healing - drug effects</subject><issn>0160-6972</issn><issn>1548-1336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkT9PwzAQxS0EoqXwCZBQJBaWwJ3_xMnAULUFiip1gdlyHae4auPiJEL99rgUGJiYTif93tO9e4RcItyiyNid1q5MV96l4xRZCsCAH5E-Cp7HnWXHpA-YQZoVkvbIWdOsAKgQAk9Jj_KCZ5DTPrmfVJUz2uwSXyXL4D_at6TSpvUhcXWyDX7jW1cvE6vDOjJNY72rW7sMunW-PicnlV439uJ7Dsjrw-Rl9JTO5o_T0XCWGkFlG88xpaScI0XOcoESpAWAinKhmQER4xgteQElClkIKNgitxnmmFNAuxBsQG4OvvGg9842rdq4xtj1WtfWd43CjMoih6j9B4oghcyLLKLXf9CV70Idg-wpXkgUdG_IDpQJMX6wldoGt9FhpxDUvgg1HE7H6nk-VWOFTH0VEVVX397dYmPLX83P59knie-BhQ</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Al-Hezaimi, Khalid</creator><creator>Nevins, Myron</creator><creator>Kim, Soo-Woo</creator><creator>Fateh, Ardavan</creator><creator>Kim, David M</creator><general>Allen Press Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20141001</creationdate><title>Efficacy of growth factor in promoting early osseointegration</title><author>Al-Hezaimi, Khalid ; Nevins, Myron ; Kim, Soo-Woo ; Fateh, Ardavan ; Kim, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-13cd724412143851707e000f245a3c05156ca7490d15795093b8e61818201eb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angiogenesis Inducing Agents - therapeutic use</topic><topic>Animals</topic><topic>Bone density</topic><topic>Coated Materials, Biocompatible - therapeutic use</topic><topic>Colleges & universities</topic><topic>Dental Implants</topic><topic>Dental Prosthesis Design</topic><topic>Dentistry</topic><topic>Dogs</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Mandible - diagnostic imaging</topic><topic>Mandible - drug effects</topic><topic>Mandible - pathology</topic><topic>Osseointegration - drug effects</topic><topic>Osteogenesis - drug effects</topic><topic>Postoperative period</topic><topic>Proto-Oncogene Proteins c-sis - therapeutic use</topic><topic>Radiography, Bitewing</topic><topic>Random Allocation</topic><topic>Recombinant Proteins</topic><topic>Software</topic><topic>Surface Properties</topic><topic>Time Factors</topic><topic>Viscosity</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Hezaimi, Khalid</creatorcontrib><creatorcontrib>Nevins, Myron</creatorcontrib><creatorcontrib>Kim, Soo-Woo</creatorcontrib><creatorcontrib>Fateh, Ardavan</creatorcontrib><creatorcontrib>Kim, David M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The Journal of oral implantology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Hezaimi, Khalid</au><au>Nevins, Myron</au><au>Kim, Soo-Woo</au><au>Fateh, Ardavan</au><au>Kim, David M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of growth factor in promoting early osseointegration</atitle><jtitle>The Journal of oral implantology</jtitle><addtitle>J Oral Implantol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>40</volume><issue>5</issue><spage>543</spage><epage>548</epage><pages>543-548</pages><issn>0160-6972</issn><eissn>1548-1336</eissn><abstract>A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.</abstract><cop>United States</cop><pub>Allen Press Inc</pub><pmid>24946082</pmid><doi>10.1563/aaid-joi-D-13-00304</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Allen Press Miscellaneous; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Angiogenesis Inducing Agents - therapeutic use Animals Bone density Coated Materials, Biocompatible - therapeutic use Colleges & universities Dental Implants Dental Prosthesis Design Dentistry Dogs Feasibility Studies Female Humans Hydroxyapatite Mandible - diagnostic imaging Mandible - drug effects Mandible - pathology Osseointegration - drug effects Osteogenesis - drug effects Postoperative period Proto-Oncogene Proteins c-sis - therapeutic use Radiography, Bitewing Random Allocation Recombinant Proteins Software Surface Properties Time Factors Viscosity Wound Healing - drug effects |
| title | Efficacy of growth factor in promoting early osseointegration |
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