Species-specific considerations in using the fish embryo test as an alternative to identify endocrine disruption

•EDC testing in fish embryos yielded species- and exposure time specific benefits.•Responses to estrogenic disruptors were similar in zebrafish and medaka.•Responses to anti-androgens differed between both species.•In zebrafish, a prolonged exposure to 96hpf showed a more indicative anti-androgenic...

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Veröffentlicht in:	Aquatic toxicology 2014-10, Vol.155, p.62-72
Hauptverfasser:	Schiller, Viktoria, Zhang, Xiaowei, Hecker, Markus, Schäfers, Christoph, Fischer, Rainer, Fenske, Martina
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists Animal, plant and microbial ecology Animals Applied ecology Aromatase - metabolism Benzhydryl Compounds Biological and medical sciences Danio rerio Ecotoxicology, biological effects of pollution Embryo, Nonmammalian - drug effects Endocrine Disruptors - metabolism Endocrine Disruptors - toxicity Endocrine System - metabolism Estrone - metabolism Ethinyl Estradiol - metabolism Fish embryo test, Endocrine disruption Fresh water environment Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Gonads - metabolism Medaka embryo Oryzias - embryology Oryzias latipes Phenols Quantitative RT-PCR Reverse Transcriptase Polymerase Chain Reaction Species Specificity Transcriptome Vitellogenins - metabolism Water Pollutants, Chemical - metabolism Water Pollutants, Chemical - toxicity Zebrafish - embryology Zebrafish embryo
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