HO-1 attenuates hippocampal neurons injury via the activation of BDNF–TrkB–PI3K/Akt signaling pathway in stroke

Abstract Although recent studies have found that HO-1 plays an important role in neuronal survival, little is known about the precise mechanisms occurring during cerebral ischemia/reperfusion (I/R). Therefore, the aim of this study was to investigate the neuroprotective mechanisms of HO-1 against is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2014-08, Vol.1577, p.69-76
Hauptverfasser:	Qi, Dashi, Ouyang, Changjie, Wang, Yulan, Zhang, Shichun, Ma, Xijuan, Song, YuanJian, Yu, HongLi, Tang, Jiali, Fu, Wei, Sheng, Lei, Yang, Lihua, Wang, Mei, Zhang, Weihao, Miao, Lei, Li, Tengteng, Huang, Xiaojing, Dong, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Biological and medical sciences Brain Ischemia - pathology Brain Ischemia - physiopathology Brain-derived neurotrophic factor (BNDF) Brain-Derived Neurotrophic Factor - metabolism CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - pathology CA1 Region, Hippocampal - physiopathology Carbazoles - pharmacology Caspase 3 - metabolism Disease Models, Animal Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism HO-1 Indole Alkaloids - pharmacology Male Medical sciences Neurology Neurons - drug effects Neurons - pathology Neurons - physiology Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt Proto-Oncogene Proteins c-akt - metabolism Rats, Sprague-Dawley Receptor, trkB - antagonists & inhibitors Receptor, trkB - metabolism Signal Transduction - drug effects Stroke Stroke - pathology Stroke - physiopathology Transfection TrkB Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!