Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus
The long-term usage of antibiotics has resulted in the evolution of multidrug-resistant bacteria. Unlike antibiotics, anti-virulence approaches target bacterial virulence without affecting cell viability, which may be less prone to develop drug resistance. Staphylococcus aureus is a major human path...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2014-11, Vol.98 (22), p.9447-9457 |
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| creator | Lee, Kayeon Lee, Jin-Hyung Kim, Soon-Il Cho, Moo Hwan Lee, Jintae |
| description | The long-term usage of antibiotics has resulted in the evolution of multidrug-resistant bacteria. Unlike antibiotics, anti-virulence approaches target bacterial virulence without affecting cell viability, which may be less prone to develop drug resistance.
Staphylococcus aureus
is a major human pathogen that produces diverse virulence factors, such as α-toxin, which is hemolytic. Also, biofilm formation of
S. aureus
is one of the mechanisms of its drug resistance. In this study, anti-biofilm screening of 83 essential oils showed that black pepper, cananga, and myrrh oils and their common constituent
cis
-nerolidol at 0.01 % markedly inhibited
S. aureus
biofilm formation. Furthermore, the three essential oils and
cis
-nerolidol at below 0.005 % almost abolished the hemolytic activity of
S. aureus
. Transcriptional analyses showed that black pepper oil down-regulated the expressions of the α-toxin gene (
hla
), the nuclease genes, and the regulatory genes. In addition, black pepper, cananga, and myrrh oils and
cis
-nerolidol attenuated
S. aureus
virulence in the nematode
Caenorhabditis elegans
. This study is one of the most extensive on anti-virulence screening using diverse essential oils and provides comprehensive data on the subject. This finding implies other beneficial effects of essential oils and suggests that black pepper, cananga, and myrrh oils have potential use as anti-virulence strategies against persistent
S. aureus
infections. |
| doi_str_mv | 10.1007/s00253-014-5903-4 |
| format | Article |
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Staphylococcus aureus
is a major human pathogen that produces diverse virulence factors, such as α-toxin, which is hemolytic. Also, biofilm formation of
S. aureus
is one of the mechanisms of its drug resistance. In this study, anti-biofilm screening of 83 essential oils showed that black pepper, cananga, and myrrh oils and their common constituent
cis
-nerolidol at 0.01 % markedly inhibited
S. aureus
biofilm formation. Furthermore, the three essential oils and
cis
-nerolidol at below 0.005 % almost abolished the hemolytic activity of
S. aureus
. Transcriptional analyses showed that black pepper oil down-regulated the expressions of the α-toxin gene (
hla
), the nuclease genes, and the regulatory genes. In addition, black pepper, cananga, and myrrh oils and
cis
-nerolidol attenuated
S. aureus
virulence in the nematode
Caenorhabditis elegans
. This study is one of the most extensive on anti-virulence screening using diverse essential oils and provides comprehensive data on the subject. This finding implies other beneficial effects of essential oils and suggests that black pepper, cananga, and myrrh oils have potential use as anti-virulence strategies against persistent
S. aureus
infections.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-014-5903-4</identifier><identifier>PMID: 25027570</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacteria ; Bacterial infections ; Biofilms ; Biofilms - drug effects ; Biomedical and Life Sciences ; Biotechnology ; Blood ; Caenorhabditis elegans ; Caenorhabditis elegans - microbiology ; Cananga ; Cananga - chemistry ; Disease Models, Animal ; Drug resistance ; Environmental Biotechnology ; Essential oils ; Gene Expression Profiling ; Hemolysis - drug effects ; Lasers ; Life Sciences ; Microbial Genetics and Genomics ; Microbiology ; Myrrh ; Nematoda ; Nematodes ; Oils & fats ; Oils, Volatile - isolation & purification ; Oils, Volatile - pharmacology ; Pathogens ; Pepper ; Physiological aspects ; Piper nigrum ; Piper nigrum - chemistry ; Properties ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - physiology ; Staphylococcus infections ; Studies ; Survival Analysis ; Terpenes - isolation & purification ; Terpenes - pharmacology ; Toxins ; Vegetables ; Virulence ; Virulence - drug effects</subject><ispartof>Applied microbiology and biotechnology, 2014-11, Vol.98 (22), p.9447-9457</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-e64fabf400ea0af54b1fee77b505153ae070ef33f1a50489faf342219105077f3</citedby><cites>FETCH-LOGICAL-c543t-e64fabf400ea0af54b1fee77b505153ae070ef33f1a50489faf342219105077f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-014-5903-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-014-5903-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25027570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Kayeon</creatorcontrib><creatorcontrib>Lee, Jin-Hyung</creatorcontrib><creatorcontrib>Kim, Soon-Il</creatorcontrib><creatorcontrib>Cho, Moo Hwan</creatorcontrib><creatorcontrib>Lee, Jintae</creatorcontrib><title>Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>The long-term usage of antibiotics has resulted in the evolution of multidrug-resistant bacteria. Unlike antibiotics, anti-virulence approaches target bacterial virulence without affecting cell viability, which may be less prone to develop drug resistance.
Staphylococcus aureus
is a major human pathogen that produces diverse virulence factors, such as α-toxin, which is hemolytic. Also, biofilm formation of
S. aureus
is one of the mechanisms of its drug resistance. In this study, anti-biofilm screening of 83 essential oils showed that black pepper, cananga, and myrrh oils and their common constituent
cis
-nerolidol at 0.01 % markedly inhibited
S. aureus
biofilm formation. Furthermore, the three essential oils and
cis
-nerolidol at below 0.005 % almost abolished the hemolytic activity of
S. aureus
. Transcriptional analyses showed that black pepper oil down-regulated the expressions of the α-toxin gene (
hla
), the nuclease genes, and the regulatory genes. In addition, black pepper, cananga, and myrrh oils and
cis
-nerolidol attenuated
S. aureus
virulence in the nematode
Caenorhabditis elegans
. This study is one of the most extensive on anti-virulence screening using diverse essential oils and provides comprehensive data on the subject. This finding implies other beneficial effects of essential oils and suggests that black pepper, cananga, and myrrh oils have potential use as anti-virulence strategies against persistent
S. aureus
infections.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - microbiology</subject><subject>Cananga</subject><subject>Cananga - chemistry</subject><subject>Disease Models, Animal</subject><subject>Drug resistance</subject><subject>Environmental Biotechnology</subject><subject>Essential oils</subject><subject>Gene Expression Profiling</subject><subject>Hemolysis - drug effects</subject><subject>Lasers</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Myrrh</subject><subject>Nematoda</subject><subject>Nematodes</subject><subject>Oils & fats</subject><subject>Oils, Volatile - isolation & purification</subject><subject>Oils, Volatile - pharmacology</subject><subject>Pathogens</subject><subject>Pepper</subject><subject>Physiological aspects</subject><subject>Piper nigrum</subject><subject>Piper nigrum - chemistry</subject><subject>Properties</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - physiology</subject><subject>Staphylococcus infections</subject><subject>Studies</subject><subject>Survival Analysis</subject><subject>Terpenes - isolation & purification</subject><subject>Terpenes - pharmacology</subject><subject>Toxins</subject><subject>Vegetables</subject><subject>Virulence</subject><subject>Virulence - drug effects</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkl2L1DAYhYso7rj6A7yRgDcK0_VNmzTt5bD4sbAguHod0sybmaxpUpN2cX6E_9mWjh8jCpKL8CbPOeGQk2VPKVxQAPEqARS8zIGynDdQ5uxetqKsLHKoKLufrYAKngve1GfZo5RuAWhRV9XD7KzgUAguYJV92_jB5q0NxrpuTdQ87bEL7pBsmuftcnZn4-jQayRKD_bODhYTCYa0TunPpMe-x7gmWnnld2pNukOMexKsO3p4jMHZbXBE7ZT1aSA3g-r3Bxd00HpMRI0Rx_Q4e2CUS_jkuJ9nn968_nj5Lr9-__bqcnOda87KIceKGdUaBoAKlOGspQZRiJYDp7xUCALQlKWhigOrG6NMyYqCNhQ4CGHK8-zF4tvH8GXENMjOJo3OKY9hTJJWhWhEzSr-HyitKYOGNxP6_A_0NozRT0FmqmrqkkP1i9oph9J6E4ao9GwqN2XdcKirYn724i_UtLbYWR08Tv-Fp4KXJ4KJGfDrsFNjSvLq5sMpSxdWx5BSRCP7aDsVD5KCnJsll2bJqVlybpZkk-bZMdzYdrj9qfhRpQkoFiBNV36H8bf0_3T9DthA1uc</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Lee, Kayeon</creator><creator>Lee, Jin-Hyung</creator><creator>Kim, Soon-Il</creator><creator>Cho, Moo Hwan</creator><creator>Lee, Jintae</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20141101</creationdate><title>Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus</title><author>Lee, Kayeon ; Lee, Jin-Hyung ; Kim, Soon-Il ; Cho, Moo Hwan ; Lee, Jintae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-e64fabf400ea0af54b1fee77b505153ae070ef33f1a50489faf342219105077f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Bacterial infections</topic><topic>Biofilms</topic><topic>Biofilms - drug effects</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Blood</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - microbiology</topic><topic>Cananga</topic><topic>Cananga - chemistry</topic><topic>Disease Models, Animal</topic><topic>Drug resistance</topic><topic>Environmental Biotechnology</topic><topic>Essential oils</topic><topic>Gene Expression Profiling</topic><topic>Hemolysis - drug effects</topic><topic>Lasers</topic><topic>Life Sciences</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Myrrh</topic><topic>Nematoda</topic><topic>Nematodes</topic><topic>Oils & fats</topic><topic>Oils, Volatile - isolation & purification</topic><topic>Oils, Volatile - pharmacology</topic><topic>Pathogens</topic><topic>Pepper</topic><topic>Physiological aspects</topic><topic>Piper nigrum</topic><topic>Piper nigrum - chemistry</topic><topic>Properties</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - physiology</topic><topic>Staphylococcus infections</topic><topic>Studies</topic><topic>Survival Analysis</topic><topic>Terpenes - isolation & purification</topic><topic>Terpenes - pharmacology</topic><topic>Toxins</topic><topic>Vegetables</topic><topic>Virulence</topic><topic>Virulence - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kayeon</creatorcontrib><creatorcontrib>Lee, Jin-Hyung</creatorcontrib><creatorcontrib>Kim, Soon-Il</creatorcontrib><creatorcontrib>Cho, Moo Hwan</creatorcontrib><creatorcontrib>Lee, Jintae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ProQuest Biological Science Collection</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kayeon</au><au>Lee, Jin-Hyung</au><au>Kim, Soon-Il</au><au>Cho, Moo Hwan</au><au>Lee, Jintae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>98</volume><issue>22</issue><spage>9447</spage><epage>9457</epage><pages>9447-9457</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>The long-term usage of antibiotics has resulted in the evolution of multidrug-resistant bacteria. Unlike antibiotics, anti-virulence approaches target bacterial virulence without affecting cell viability, which may be less prone to develop drug resistance.
Staphylococcus aureus
is a major human pathogen that produces diverse virulence factors, such as α-toxin, which is hemolytic. Also, biofilm formation of
S. aureus
is one of the mechanisms of its drug resistance. In this study, anti-biofilm screening of 83 essential oils showed that black pepper, cananga, and myrrh oils and their common constituent
cis
-nerolidol at 0.01 % markedly inhibited
S. aureus
biofilm formation. Furthermore, the three essential oils and
cis
-nerolidol at below 0.005 % almost abolished the hemolytic activity of
S. aureus
. Transcriptional analyses showed that black pepper oil down-regulated the expressions of the α-toxin gene (
hla
), the nuclease genes, and the regulatory genes. In addition, black pepper, cananga, and myrrh oils and
cis
-nerolidol attenuated
S. aureus
virulence in the nematode
Caenorhabditis elegans
. This study is one of the most extensive on anti-virulence screening using diverse essential oils and provides comprehensive data on the subject. This finding implies other beneficial effects of essential oils and suggests that black pepper, cananga, and myrrh oils have potential use as anti-virulence strategies against persistent
S. aureus
infections.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25027570</pmid><doi>10.1007/s00253-014-5903-4</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2014-11, Vol.98 (22), p.9447-9457 |
| issn | 0175-7598 1432-0614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1627978465 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacterial infections Biofilms Biofilms - drug effects Biomedical and Life Sciences Biotechnology Blood Caenorhabditis elegans Caenorhabditis elegans - microbiology Cananga Cananga - chemistry Disease Models, Animal Drug resistance Environmental Biotechnology Essential oils Gene Expression Profiling Hemolysis - drug effects Lasers Life Sciences Microbial Genetics and Genomics Microbiology Myrrh Nematoda Nematodes Oils & fats Oils, Volatile - isolation & purification Oils, Volatile - pharmacology Pathogens Pepper Physiological aspects Piper nigrum Piper nigrum - chemistry Properties Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Staphylococcus infections Studies Survival Analysis Terpenes - isolation & purification Terpenes - pharmacology Toxins Vegetables Virulence Virulence - drug effects |
| title | Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus |
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