Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells

•LPS reduces the expression of GDNF in Sertoli cells and its conditioned media but not BMP4 or SCF.•LPS can decrease the expression of SSC self-renewal genes and increase the expression of SSC differentiation genes.•LPS can also depress the expression of GDNF downstream genes. Lipopolysaccharide (LP...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2014-06, Vol.45, p.87-93
Hauptverfasser:	Zhang, Xiaoli, Shi, Kun, Li, Yi, Zhang, Haiyu, Hao, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - drug effects Cells, Cultured Differentiation DNA-Binding Proteins - genetics Down-Regulation GDNF Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - metabolism Lipopolysaccharides - pharmacology LPS Male Mice Repressor Proteins - genetics RNA, Messenger - metabolism Self-renewal Sertoli cells Sertoli Cells - drug effects Sertoli Cells - metabolism Spermatogonia - cytology Spermatogonial stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Transcription Factors - genetics
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