TFII-I regulates target genes in the PI-3K and TGF-β signaling pathways through a novel DNA binding motif

General transcription factor (TFII-I) is a multi-functional protein involved in the transcriptional regulation of critical developmental genes, encoded by the GTF2I gene located on chromosome 7q11.23. Haploinsufficiency at GTF2I has been shown to play a major role in the neurodevelopmental features...

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Veröffentlicht in:	Gene 2013-09, Vol.527 (2), p.529-536
Hauptverfasser:	Segura-Puimedon, Maria, Borralleras, Cristina, Pérez-Jurado, Luis A., Campuzano, Victoria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites chromatin cortex DNA DNA - metabolism DNA binding domain Embryonic stem cells fibroblasts genes Humans Mice microarray technology Mouse model mutants phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism precipitin tests promoter regions Promoter Regions, Genetic quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction screening signal transduction Signal Transduction - physiology TFII-I transcription (genetics) transcription factors Transcription Factors, TFII - physiology Transcriptional regulation transforming growth factor beta Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Williams–Beuren syndrome
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